GENE：MICU1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MICU1 |
| FullNmae | mitochondrial calcium uptake 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1530 |
| EnsembleID | ENSG00000107745 |
| Uniprot | Q9BPX6 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MICU1 | mpt | 33041854 | The mitochondrial calcium uniporter complex through which calcium enters the mitochondria is composed of several proteins, including the pore-forming subunit MCU and its regulators MCUR1, MICU1, and MICU2. Mitochondrial calcium overload leads to opening of MPTP (mitochondrial permeability transition pore) and results in apoptotic cell death. | retulator signature |
| MICU1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MICU1 | GO:0005509,GO:0005509,GO:0005509,GO:0005515,GO:0005739,GO:0005739,GO:0005743,GO:0005743,GO:0005743,GO:0005743,GO:0005758,GO:0006851,GO:0006851,GO:0006952,GO:0031966,GO:0034704,GO:0036444,GO:0036444,GO:0036444,GO:0036444,GO:0042802,GO:0046982,GO:0051260,GO:0051560,GO:0051560,GO:0051560,GO:0051560,GO:0051561,GO:0051561,GO:0070509,GO:1900069,GO:1990246,GO:1990246,GO:1990246,GO:1990246,GO:1990246 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | MICU1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | MICU1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | MICU1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | MICU1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | MICU1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | MICU1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP73 | MICU1 | 19558638 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | MICU1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MICU1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MICU1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MICU1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | MICU1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MICU1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MICU1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | MICU1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PPP1R15A | MICU1 | 24234451 25348397 29109149 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TUBA1B | MICU1 | 25348397 | N/A | physical interaction | ComPPI |
| CDH5 | MICU1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | MICU1 | 25348397 | N/A | physical interaction | ComPPI |
| SQSTM1 | MICU1 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| CD79A | MICU1 | 25348397 | N/A | physical interaction | ComPPI |
| CD79B | MICU1 | 25348397 | N/A | physical interaction | ComPPI |
| AURKB | MICU1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| AARS1 | MICU1 | 24234451 25348397 | physical association | physical interaction,inference by socio-affinity scoring | ComPPI,IntAct |
| BABAM1 | MICU1 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| AIFM1 | MICU1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| DCAF11 | MICU1 | 25348397 | N/A | physical interaction | ComPPI |
| SLX4 | MICU1 | 19596235 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| APP | MICU1 | 25348397 | N/A | physical interaction | ComPPI |
| SFXN1 | MICU1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| COX6B1 | MICU1 | 24234451 25348397 27499296 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| MICU1 | SLC18A1 | 25348397 | N/A | physical interaction | ComPPI |
| MICU1 | KLHL22 | 25348397 | N/A | physical interaction | ComPPI |
| MICU1 | GPN3 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM44 | MICU1 | 25348397 | N/A | physical interaction | ComPPI |