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GENE：MIB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MIB2
FullNmae MIB E3 ubiquitin protein ligase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30577
EnsembleID ENSG00000197530
Uniprot Q96AX9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MIB2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MIB2 GO:0000151,GO:0003779,GO:0004842,GO:0004842,GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0007219,GO:0008270,GO:0010803,GO:0016567,GO:0016567,GO:0043123,GO:0061630

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MIB2 hsa:142678 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MIB2 JAG1 26192618 interaction type N/A ACSN
MIB2 JAG2 15920166 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA2 MIB2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MIB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MIB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MIB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MIB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MIB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MIB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MIB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MIB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MIB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 MIB2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000BE495 MIB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000419B5A MIB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000004DB7E MIB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 MIB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002CBC6D MIB2 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UBE2N MIB2 25348397 N/A physical interaction ComPPI
XRCC5 MIB2 25348397 N/A physical interaction ComPPI
F9 MIB2 25348397 N/A physical interaction ComPPI
GRIN2B MIB2 17962190 25348397 27898060 N/A physical interaction ComPPI,OmniPath
JAG2 MIB2 25348397 N/A physical interaction ComPPI
HIF1AN MIB2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP3K7 MIB2 25348397 N/A physical interaction ComPPI
IKZF1 MIB2 25348397 N/A physical interaction ComPPI
TBK1 MIB2 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BCL10 MIB2 25348397 N/A physical interaction ComPPI
SRPK2 MIB2 25348397 N/A physical interaction ComPPI
MIB1 MIB2 21903422 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
P2RY1 MIB2 25348397 N/A physical interaction ComPPI
NUP58 MIB2 25348397 N/A physical interaction ComPPI
IKZF5 MIB2 25348397 N/A physical interaction ComPPI
ACTA1 MIB2 25348397 N/A physical interaction ComPPI
CYLD MIB2 25348397 25565632 27898060 N/A physical interaction ComPPI,OmniPath
IST1 MIB2 25348397 N/A physical interaction ComPPI
MAVS MIB2 25348397 N/A physical interaction ComPPI
AZI2 MIB2 21903422 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MIB2 UBE2U 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MIB2 IKBKG 25348397 N/A physical interaction ComPPI
MIB2 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MIB2 NAF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCL MIB2 24234451 30021884 physical association cross-linking study IntAct
MIB2 JAG2 15920166 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BAED8 MIB2 27087310 direct interaction,inhibition N/A NPInter

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