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GENE：KLF2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KLF2
FullNmae KLF transcription factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6347
EnsembleID ENSG00000127528
Uniprot Q9Y5W3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KLF2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KLF2 GO:0000122,GO:0000785,GO:0000785,GO:0000902,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001701,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0032715,GO:0035264,GO:0036003,GO:0040029,GO:0042311,GO:0043249,GO:0045429,GO:0045893,GO:0045944,GO:0045944,GO:0046872,GO:0048386,GO:0051247,GO:0060509,GO:0070301,GO:0071347,GO:0071356,GO:0071409,GO:0071498,GO:0071499,GO:0097533,GO:1901653,GO:1903671,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KLF2 hsa:10365 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
KLF2 hsa:10365 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
KLF2 hsa:10365 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
KLF2 EGR1 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR KLF2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 KLF2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 KLF2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 KLF2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NR1I2 KLF2 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 KLF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA KLF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 KLF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 KLF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KLF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 KLF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS KLF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A KLF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXO1 KLF2 23002242 trascriptional regulation,stimulation inferred by curator TFlink
HNRNPD KLF2 15835916 trascriptional regulation,stimulation inferred by curator TFlink
NANOG KLF2 22378194 trascriptional regulation,stimulation inferred by curator TFlink
TP53 KLF2 23202365 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C0099 KLF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 KLF2 23446348 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041FA2C KLF2 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F KLF2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 KLF2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000321A1A KLF2 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D KLF2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 KLF2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A KLF2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F KLF2 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C KLF2 22012620 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC KLF2 19536157 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 KLF2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004818BD KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004DEA91 KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005FDCD1 KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005651EE KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002D349B KLF2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D KLF2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF KLF2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 KLF2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 KLF2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 KLF2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 KLF2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF KLF2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA KLF2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 KLF2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001DA458 KLF2 25416803 26299712 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002373FD KLF2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006DE17B KLF2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 KLF2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AB0E KLF2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 KLF2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000005A8ED KLF2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 KLF2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KLF2 WWP1 25361965 interaction type N/A PTMCode2
WWP1 KLF2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FBXW7 KLF2 23507969 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CREBBP KLF2 25348397 N/A physical interaction ComPPI
EP300 KLF2 14525934 15136591 21482710 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
KAT2B KLF2 16617118 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
WWP1 KLF2 11375995 14525934 15003522 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
GSK3B KLF2 25348397 N/A physical interaction ComPPI
SMURF1 KLF2 21382345 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct,OmniPath
PSME3 KLF2 25348397 26776519 27898060 N/A physical interaction ComPPI,OmniPath
ELAVL1 KLF2 25348397 N/A physical interaction ComPPI
KLF2 GATA5 25348397 N/A physical interaction ComPPI
KLF2 GATA6 25348397 N/A physical interaction ComPPI
KLF2 FOXO1 18713968 24234451 association chromatin immunoprecipitation assay IntAct
KLF2 CXCR4 19671192 27898060 inhibition N/A OmniPath
KLF2 NFE2L2 18467642 27898060 stimulant N/A OmniPath

Visualization










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