Gene Information gene info

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GENE：DDR2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DDR2
FullNmae discoidin domain receptor tyrosine kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2731
EnsembleID ENSG00000162733
Uniprot Q16832

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DDR2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DDR2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DDR2 GO:0001503,GO:0003416,GO:0004714,GO:0005515,GO:0005518,GO:0005518,GO:0005524,GO:0005886,GO:0005886,GO:0005925,GO:0007155,GO:0007165,GO:0007169,GO:0007275,GO:0010715,GO:0010763,GO:0010763,GO:0010976,GO:0015629,GO:0016324,GO:0018108,GO:0030199,GO:0030500,GO:0031214,GO:0032967,GO:0033674,GO:0034103,GO:0035988,GO:0035988,GO:0035994,GO:0038062,GO:0038062,GO:0038063,GO:0043066,GO:0043235,GO:0045669,GO:0045860,GO:0046777,GO:0048146,GO:0051091,GO:0051897,GO:0071456,GO:0071560,GO:0090091,GO:0090303,GO:1900087,GO:1901299,GO:1904385,GO:1904707,GO:1904754,GO:1904899,GO:2000491

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DDR2 SHC1 11884411 23331499 stimulation N/A SignaLink
DDR2 SRC 11884411 16186108 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SHC1 DDR2 20005715 interaction type N/A PSP
SHC1 DDR2 11884411 11884411 11884411 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR DDR2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 DDR2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 DDR2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 DDR2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C DDR2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA DDR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DDR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DDR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DDR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DDR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DDR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DDR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 DDR2 20564243 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D DDR2 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AF45F DDR2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00005CCD18 DDR2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 DDR2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 DDR2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C DDR2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 DDR2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 DDR2 22291592 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 DDR2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE DDR2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000450F92 DDR2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000057FDB8 DDR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000081D1E DDR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001310DE DDR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 DDR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A DDR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A DDR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 DDR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000048F59D DDR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCDA3 DDR2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 DDR2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00004283FE DDR2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000D2680 DDR2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00004BC299 DDR2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC DDR2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
HSP90AB1 DDR2 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
CBLB DDR2 24234451 24631539 25348397 26826182 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
SRC DDR2 11884411 14525934 16186108 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SHC1 DDR2 11884411 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
HSP90AA1 DDR2 25348397 N/A physical interaction ComPPI
NTRK1 DDR2 25348397 N/A physical interaction ComPPI
CDH1 DDR2 25348397 N/A physical interaction ComPPI
DDR2 COL1A1 14525934 25348397 9659899 N/A experimental interaction detection,in vitro ComPPI,HPRD
DDR2 COL3A1 14525934 25348397 9659899 N/A experimental interaction detection,in vitro ComPPI,HPRD
DDR2 ELAVL1 25348397 N/A physical interaction ComPPI
DDR2 HSP90AA2P 25348397 N/A physical interaction ComPPI
DDR2 CDH2 25348397 N/A physical interaction ComPPI
DDR2 CHORDC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDR2 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDR2 COL11A2 17703188 24234451 25348397 27898060 N/A nuclear magnetic resonance,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct,OmniPath
DDR2 CDC37 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SRC DDR2 11884411 16186108 18083107 27898060 stimulant N/A OmniPath
DDR2 SHC1 11884411 16186108 27898060 stimulant N/A OmniPath
COL1A1 DDR2 12611880 27898060 9659899 stimulant N/A OmniPath
CSNK2A1 DDR2 11884411 16186108 27898060 N/A N/A OmniPath

Visualization










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