Gene Information gene info

GENE:ACSL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACSL1
FullNmae acyl-CoA synthetase long chain family member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3569
EnsembleID ENSG00000151726
Uniprot P33121

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACSL1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACSL1 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ACSL1 GO:0000038,GO:0001676,GO:0001676,GO:0004467,GO:0004467,GO:0005524,GO:0005739,GO:0005739,GO:0005741,GO:0005778,GO:0005783,GO:0005783,GO:0005789,GO:0007584,GO:0008610,GO:0008610,GO:0010747,GO:0014070,GO:0015908,GO:0016020,GO:0016020,GO:0019432,GO:0033211,GO:0034201,GO:0035338,GO:0035338,GO:0042178,GO:0043539,GO:0044539,GO:0044539,GO:0047676,GO:0047676,GO:0050197,GO:0070251,GO:0090434,GO:0120162

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACSL1 hsa:2180 path:hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
ACSL1 hsa:2180 path:hsa00071 Fatty acid degradation - Homo sapiens (human)
ACSL1 hsa:2180 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACSL1 hsa:2180 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)
ACSL1 hsa:2180 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)
ACSL1 hsa:2180 path:hsa04146 Peroxisome - Homo sapiens (human)
ACSL1 hsa:2180 path:hsa04216 Ferroptosis - Homo sapiens (human)
ACSL1 hsa:2180 path:hsa04714 Thermogenesis - Homo sapiens (human)
ACSL1 hsa:2180 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ACSL1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F4 ACSL1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 ACSL1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ACSL1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 ACSL1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ACSL1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR ACSL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARA ACSL1 17150915 trascriptional regulation,stimulation inferred by curator TFlink
E2F2 ACSL1 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 ACSL1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 ACSL1 21566225 rna interference,inhibition experimental interaction detection miRSponge
URS0000237AF9 ACSL1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 ACSL1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS00000B59A2 ACSL1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 ACSL1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000DDD35 ACSL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002B2B5C ACSL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000016914 ACSL1 24462768 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000008931A ACSL1 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB ACSL1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA ACSL1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NTRK1 ACSL1 25348397 N/A physical interaction ComPPI
ECT2 ACSL1 25348397 N/A physical interaction ComPPI
PRKN ACSL1 25348397 N/A physical interaction ComPPI
TRIM25 ACSL1 25348397 N/A physical interaction ComPPI
NR3C2 ACSL1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
COX6B1 ACSL1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFA4 ACSL1 25348397 N/A physical interaction ComPPI

Visualization