GENE:ACSL1
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | ACSL1 |
FullNmae | acyl-CoA synthetase long chain family member 1 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:3569 |
EnsembleID | ENSG00000151726 |
Uniprot | P33121 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
ACSL1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
ACSL1 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
ACSL1 | GO:0000038,GO:0001676,GO:0001676,GO:0004467,GO:0004467,GO:0005524,GO:0005739,GO:0005739,GO:0005741,GO:0005778,GO:0005783,GO:0005783,GO:0005789,GO:0007584,GO:0008610,GO:0008610,GO:0010747,GO:0014070,GO:0015908,GO:0016020,GO:0016020,GO:0019432,GO:0033211,GO:0034201,GO:0035338,GO:0035338,GO:0042178,GO:0043539,GO:0044539,GO:0044539,GO:0047676,GO:0047676,GO:0050197,GO:0070251,GO:0090434,GO:0120162 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
ACSL1 | hsa:2180 | path:hsa00061 | Fatty acid biosynthesis - Homo sapiens (human) |
ACSL1 | hsa:2180 | path:hsa00071 | Fatty acid degradation - Homo sapiens (human) |
ACSL1 | hsa:2180 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
ACSL1 | hsa:2180 | path:hsa01212 | Fatty acid metabolism - Homo sapiens (human) |
ACSL1 | hsa:2180 | path:hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
ACSL1 | hsa:2180 | path:hsa04146 | Peroxisome - Homo sapiens (human) |
ACSL1 | hsa:2180 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
ACSL1 | hsa:2180 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
ACSL1 | hsa:2180 | path:hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | ACSL1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
E2F4 | ACSL1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
ESR1 | ACSL1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | ACSL1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA3 | ACSL1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXP3 | ACSL1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
SMARCA4 | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TAL1 | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
VDR | ACSL1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PPARA | ACSL1 | 17150915 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F2 | ACSL1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
POU2F1 | ACSL1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00000EED18 | ACSL1 | 21566225 | rna interference,inhibition | experimental interaction detection | miRSponge |
URS0000237AF9 | ACSL1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00000EED18 | ACSL1 | 21566225 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,experimental interaction detection | TarBase |
URS00000B59A2 | ACSL1 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000324096 | ACSL1 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
URS00000DDD35 | ACSL1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00002B2B5C | ACSL1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS0000016914 | ACSL1 | 24462768 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS000008931A | ACSL1 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000285DCB | ACSL1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001E0AEA | ACSL1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
NTRK1 | ACSL1 | 25348397 | N/A | physical interaction | ComPPI |
ECT2 | ACSL1 | 25348397 | N/A | physical interaction | ComPPI |
PRKN | ACSL1 | 25348397 | N/A | physical interaction | ComPPI |
TRIM25 | ACSL1 | 25348397 | N/A | physical interaction | ComPPI |
NR3C2 | ACSL1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
COX6B1 | ACSL1 | 24234451 25348397 27499296 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
NDUFA4 | ACSL1 | 25348397 | N/A | physical interaction | ComPPI |