GENE：IDO1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | IDO1 |
| FullNmae | indoleamine 2,3-dioxygenase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6059 |
| EnsembleID | ENSG00000131203 |
| Uniprot | P14902 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| IDO1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IDO1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| IDO1 | GO:0002666,GO:0002678,GO:0002830,GO:0004833,GO:0005737,GO:0005829,GO:0006569,GO:0006954,GO:0007565,GO:0009055,GO:0019441,GO:0019441,GO:0020037,GO:0022900,GO:0030485,GO:0032421,GO:0032496,GO:0032693,GO:0032735,GO:0033555,GO:0033754,GO:0033754,GO:0034276,GO:0034354,GO:0036269,GO:0042098,GO:0042130,GO:0046872,GO:0070233,GO:0070234 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| IDO1 | hsa:3620 | path:hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| IDO1 | hsa:3620 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| IDO1 | hsa:3620 | path:hsa01240 | Biosynthesis of cofactors - Homo sapiens (human) |
| IDO1 | hsa:3620 | path:hsa05143 | African trypanosomiasis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IDO1 | PPP1R16A | 16169070 23180781 | physical association | two hybrid | InnateDB |
| DDX24 | IDO1 | 16169070 23180781 | physical association | two hybrid | InnateDB |
| IDO1 | STAT1 | 16785527 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IDO1 | IFNGR1 | 16785527 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IDO1 | IFNG | 16785527 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SMARCA4 | IDO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | IDO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | IDO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | IDO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | IDO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR2 | IDO1 | 24007274 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PTMA | IDO1 | 21176371 21575365 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PPP1R16A | IDO1 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| TERF2IP | IDO1 | 21044950 24234451 25348397 | physical association | physical interaction,bimolecular fluorescence complementation | ComPPI,IntAct |
| DDX24 | IDO1 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| IDO1 | APP | 25348397 | N/A | physical interaction | ComPPI |
| SOCS3 | IDO1 | 19088199 27898060 | N/A | N/A | OmniPath |