Gene Information gene info

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GENE：GJA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GJA1
FullNmae gap junction protein alpha 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4274
EnsembleID ENSG00000152661
Uniprot P17302

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GJA1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GJA1 GO:0000132,GO:0000139,GO:0003161,GO:0005243,GO:0005243,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005789,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005921,GO:0005921,GO:0005922,GO:0005922,GO:0005925,GO:0007165,GO:0007267,GO:0007267,GO:0007283,GO:0007507,GO:0008013,GO:0008104,GO:0010628,GO:0010644,GO:0010644,GO:0014047,GO:0014704,GO:0014704,GO:0015075,GO:0015562,GO:0015631,GO:0016264,GO:0016324,GO:0030054,GO:0030308,GO:0030660,GO:0032277,GO:0034220,GO:0034634,GO:0034775,GO:0035633,GO:0042908,GO:0043123,GO:0043231,GO:0044291,GO:0045121,GO:0046849,GO:0055077,GO:0060348,GO:0070160,GO:0086014,GO:0086064,GO:0086075,GO:0120162,GO:0140115,GO:1901164,GO:1903763,GO:1904646,GO:1904707,GO:1905332,GO:1905772,GO:2000648

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GJA1 hsa:2697 path:hsa04540 Gap junction - Homo sapiens (human)
GJA1 hsa:2697 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GJA1 PRKCG 20005715 interaction type N/A PSP
GJA1 PRKCB 20005715 interaction type N/A PSP
GJA1 SRC 20005715 interaction type N/A PSP
GJA1 PRKCA 20005715 interaction type N/A PSP
GJA1 MAPK3 20005715 interaction type N/A PSP
GJA1 MAPK1 20005715 interaction type N/A PSP
GJA1 CSK 20005715 interaction type N/A PSP
GJA1 CSNK1D 20005715 interaction type N/A PSP
GJA1 PRKCE 20005715 interaction type N/A PSP
GJA1 MAPK7 20005715 interaction type N/A PSP
GJA1 SRC 20005715 N/A N/A SignaLink
GJA1 CSK 20005715 20005715 N/A N/A SignaLink
GJA1 CSNK1D 12270943 20005715 20005715 21071413 N/A N/A SignaLink
GJA1 MAPK1 20005715 20005715 N/A N/A SignaLink
GJA1 MAPK3 20005715 20005715 N/A N/A SignaLink
GJA1 MAPK7 12637502 20005715 20005715 21071413 N/A N/A SignaLink
GJA1 PRKCA 11273731 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR GJA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 GJA1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 GJA1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GJA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GJA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GJA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 GJA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN GJA1 10421804 trascriptional regulation,stimulation inferred by curator TFlink
SP1 GJA1 10421804 19679555 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 GJA1 10421804 19679555 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000034B6F5 GJA1 N/A 17062625 18155131 rna interference,inhibition experimental interaction detection,western blot miRSponge
URS000034B6F5 GJA1 17062625 25416803 28342807 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000148B91 GJA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED GJA1 23622248 25416803 26283635 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clash,miRNA interference luciferase reporter assay TarBase
URS0000170CF4 GJA1 22294051 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS0000153377 GJA1 22294051 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS0000042E1F GJA1 22785209 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000315338 GJA1 24819345 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS000049FAE8 GJA1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC864 GJA1 25416803 25798059 26191074 26283635 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000008DA94 GJA1 25416803 26283635 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000021D7C8 GJA1 25416803 26283635 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00001FFA8C GJA1 25416803 26283635 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
SRC GJA1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK14 GJA1 22135298 phosphorylation N/A PhosphoSite
PRKCE GJA1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK1 GJA1 25361965 interaction type N/A PTMCode2
GJA1 MAPK1 25361965 interaction type N/A PTMCode2
PRKCG GJA1 25361965 interaction type N/A PTMCode2
GJA1 PRKCG 25361965 interaction type N/A PTMCode2
CSK GJA1 25361965 interaction type N/A PTMCode2
GJA1 CSK 25361965 interaction type N/A PTMCode2
GJA1 PRKCA 25361965 interaction type N/A PTMCode2
PRKCA GJA1 25361965 interaction type N/A PTMCode2
GJA1 PRKCE 25361965 interaction type N/A PTMCode2
GJA1 MAPK7 25361965 interaction type N/A PTMCode2
MAPK7 GJA1 25361965 interaction type N/A PTMCode2
GJA1 CSNK1D 25361965 interaction type N/A PTMCode2
CSNK1D GJA1 25361965 interaction type N/A PTMCode2
GJA1 CAV1 25361965 interaction type N/A PTMCode2
CAV1 GJA1 25361965 interaction type N/A PTMCode2
GJA1 SRC 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
S100A1 GJA1 12804600 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DPEP1 GJA1 25348397 N/A physical interaction ComPPI
CSNK1D GJA1 12270943 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK1 GJA1 12637502 14525934 25348397 8631994 9535905 9535909 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCA GJA1 10871288 11273731 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SRC GJA1 11035005 11514593 14525934 24234451 25348397 9278444 association experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
CCN3 GJA1 14525934 15181016 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
MAPK3 GJA1 12637502 14525934 25348397 8631994 9535905 9535909 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCE GJA1 10679481 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YWHAZ GJA1 25348397 N/A physical interaction ComPPI
HGS GJA1 25348397 N/A physical interaction ComPPI
CAV1 GJA1 11980479 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKCB GJA1 10871288 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
STXBP1 GJA1 25348397 N/A physical interaction ComPPI
PRKCG GJA1 10871288 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
YWHAQ GJA1 25348397 N/A physical interaction ComPPI
MAPK7 GJA1 12637502 14525934 25348397 8631994 9535905 9535909 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CSK GJA1 11035005 14525934 24234451 25348397 N/A experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
EPS15 GJA1 19835873 21554242 25070368 25348397 27898060 N/A physical interaction ComPPI,OmniPath
STXBP2 GJA1 25348397 N/A physical interaction ComPPI
TFCP2 GJA1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
UBQLN4 GJA1 18079109 20940304 24256120 25348397 25583071 27898060 N/A physical interaction ComPPI,OmniPath
UBE2A GJA1 25348397 N/A physical interaction ComPPI
TSG101 GJA1 25348397 N/A physical interaction ComPPI
PSMD2 GJA1 25348397 N/A physical interaction ComPPI
CREB3 GJA1 25348397 N/A two hybrid bait and prey pooling approach ComPPI
PSMD4 GJA1 25348397 N/A physical interaction ComPPI
NEDD4 GJA1 16931598 19835873 19907029 21936631 24236122 25348397 25748165 26841867 27898060 N/A physical interaction ComPPI,OmniPath
FSHR GJA1 25348397 N/A physical interaction ComPPI
STAMBP GJA1 25348397 N/A physical interaction ComPPI
GJA5 GJA1 11557558 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TGOLN2 GJA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BET1 GJA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HTR3A GJA1 25348397 N/A physical interaction ComPPI
UPK1A GJA1 25348397 N/A physical interaction ComPPI
EEF1A2 GJA1 25348397 N/A physical interaction ComPPI
GJA1 TJP1 14525934 16944923 24234451 25348397 9707407 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
GJA1 CNST 25348397 N/A physical interaction ComPPI
GJA1 KCNK16 25348397 N/A physical interaction ComPPI
GJA1 TSPAN17 25348397 N/A physical interaction ComPPI
GJA1 GPR52 25348397 N/A physical interaction ComPPI
GJA1 NT5E 25348397 N/A physical interaction ComPPI
GJA1 SLC39A4 25348397 N/A physical interaction ComPPI
GJA1 NDUFA7 25348397 N/A physical interaction ComPPI
GJA1 FAM189A2 25348397 N/A physical interaction ComPPI
GJA1 ZACN 25348397 N/A physical interaction ComPPI
GJA1 HTR3C 25348397 N/A physical interaction ComPPI
GJA1 ADGRG5 25348397 N/A physical interaction ComPPI
GJA1 SLC39A12 25348397 N/A physical interaction ComPPI
GJA1 STS 25348397 N/A physical interaction ComPPI
GJA1 B4GAT1 25348397 N/A physical interaction ComPPI
GJA1 GPR21 25348397 N/A physical interaction ComPPI
GJA1 TMPRSS3 25348397 N/A physical interaction ComPPI
GJA1 NINJ2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GJA1 PLPP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GJA1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
GJA1 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TMEM86B GJA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GJA3 GJA1 11739633 14525934 N/A experimental interaction detection HPRD
SGSM3 GJA1 14525934 15709751 27898060 N/A experimental interaction detection,two hybrid HPRD,OmniPath
HTR2C GJA1 24234451 28298427 physical association ubiquitin reconstruction IntAct
L1TD1 GJA1 24234451 25702638 association anti bait coimmunoprecipitation IntAct
UBC GJA1 14970263 15371442 22871113 24236122 27898060 N/A N/A OmniPath
SRC GJA1 11035005 11514593 16916748 19901323 27898060 9278444 inhibition N/A OmniPath
PRKCA GJA1 10871288 11273731 14702389 27898060 inhibition N/A OmniPath
PRKCB GJA1 10871288 27898060 N/A N/A OmniPath
PRKCE GJA1 10679481 15534005 15605363 16474210 17629739 17724204 18665255 22737133 22960107 24742583 26161412 27898060 stimulant N/A OmniPath
TJP1 GJA1 16944923 27898060 9707407 N/A N/A OmniPath
PTPN2 GJA1 24849651 27898060 stimulant N/A OmniPath
MAPK7 GJA1 12637502 19664994 27898060 8631994 9535905 9535909 inhibition,stimulant N/A OmniPath
PRKCG GJA1 10871288 15459208 27898060 N/A N/A OmniPath
MAPK3 GJA1 12637502 19664994 27898060 8631994 9535905 9535909 inhibition N/A OmniPath
MAPK14 GJA1 15605363 15958277 24399133 27898060 N/A N/A OmniPath
CSNK1D GJA1 12270943 18578522 27898060 stimulant N/A OmniPath
MAPK1 GJA1 12637502 19664994 27898060 8631994 9535905 9535909 inhibition N/A OmniPath

Visualization










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