GENE：LIFR
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LIFR |
| FullNmae | LIF receptor subunit alpha |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6597 |
| EnsembleID | ENSG00000113594 |
| Uniprot | P42702 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LIFR | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LIFR | GO:0004896,GO:0004897,GO:0004923,GO:0004924,GO:0004924,GO:0005127,GO:0005127,GO:0005515,GO:0005886,GO:0007166,GO:0008284,GO:0008284,GO:0009897,GO:0019221,GO:0019221,GO:0019838,GO:0019955,GO:0034097,GO:0038165,GO:0043235,GO:0043235,GO:0048861,GO:0070062,GO:0070120 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LIFR | hsa:3977 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| LIFR | hsa:3977 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| LIFR | hsa:3977 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| JAK1 | LIFR | 11306493 19833085 21840487 22595692 24857661 26192618 7512720 7521688 | interaction type | N/A | ACSN |
| LIF | LIFR | 10428964 11306493 12601009 16051226 19833085 21840487 22595692 23331499 24857661 26192618 7512720 7521688 | interaction type,stimulation | N/A | ACSN,SignaLink |
| LIFR | STAT3 | 10582086 11306493 19833085 21840487 22595692 23331499 24857661 26192618 7512720 7521688 | interaction type,stimulation | N/A | ACSN,SignaLink |
| LIFR | IL6ST | 16254248 21071413 23331499 8999038 | stimulation | N/A | SignaLink,SignaLink |
| LIFR | JAK2 | 11294841 23331499 | stimulation | N/A | SignaLink |
| LIFR | TYK2 | 11294841 23331499 | stimulation | N/A | SignaLink |
| LIFR | JAK1 | 11294841 23331499 | stimulation | N/A | SignaLink |
| LIFR | STAT1 | 10582086 23331499 | stimulation | N/A | SignaLink |
| CTF1 | LIFR | 11834704 23331499 9030543 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LIFR | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | LIFR | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | LIFR | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | LIFR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LIFR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | LIFR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LIFR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | LIFR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | LIFR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU2F1 | LIFR | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | LIFR | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000122ED0 | LIFR | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001B341F | LIFR | 20371350 21572407 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS000009262D | LIFR | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000002103A | LIFR | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00004DA9DB | LIFR | 22100165 24247238 25416803 | mrna cleavage,inhibition | western blot,clip,miRNA interference luciferase reporter assay | TarBase |
| URS00001F0C23 | LIFR | 21788734 25416803 25962054 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000028DE3F | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001597DC | LIFR | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000302909 | LIFR | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077AED | LIFR | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D4175 | LIFR | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C7662 | LIFR | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000136174 | LIFR | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000266339 | LIFR | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000572E11 | LIFR | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000028D811 | LIFR | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000007FBA | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001AFC71 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000028BB8 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003ABC4 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000330617 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013ABA3 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E92A8 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | LIFR | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032015F | LIFR | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK3 | LIFR | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK1 | LIFR | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| LIFR | MAPK1 | 25361965 | interaction type | N/A | PTMCode2 |
| LIFR | IL6ST | 25361965 | interaction type | N/A | PTMCode2 |
| IL6ST | LIFR | 25361965 | interaction type | N/A | PTMCode2 |
| LIFR | CNTF | 25361965 | interaction type | N/A | PTMCode2 |
| CNTF | LIFR | 25361965 | interaction type | N/A | PTMCode2 |
| LIFR | PTPN6 | 25361965 | interaction type | N/A | PTMCode2 |
| PTPN6 | LIFR | 25361965 | interaction type | N/A | PTMCode2 |
| LIF | LIFR | 25361965 | interaction type | N/A | PTMCode2 |
| LIFR | LIF | 25361965 | interaction type | N/A | PTMCode2 |
| OSM | LIFR | 25361965 | interaction type | N/A | PTMCode2 |
| LIFR | OSM | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BAG3 | LIFR | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PTPN6 | LIFR | 10800945 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CNTF | LIFR | 12643274 14525934 16051226 18775332 24234451 25348397 | physical association | coimmunoprecipitation,electron microscopy,experimental interaction detection,isothermal titration calorimetry,molecular sieving,pull down,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| TAFA4 | LIFR | 25348397 | N/A | physical interaction | ComPPI |
| MAPK1 | LIFR | 14525934 25348397 7777512 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| IL6ST | LIFR | 12047380 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PTPN11 | LIFR | 10800945 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| SLAMF1 | LIFR | 25348397 | N/A | physical interaction | ComPPI |
| OSM | LIFR | 14525934 1536831 1542794 16051226 24234451 25348397 | N/A | coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| CTF1 | LIFR | 11834704 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TRIM25 | LIFR | 25348397 | N/A | physical interaction | ComPPI |
| LIF | LIFR | 12601009 14525934 16051226 24234451 25348397 | N/A | affinity chromatography technology,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,biochemical,in vitro | ComPPI,HPRD,IntAct |
| IL31RA | LIFR | 14504285 14525934 15184896 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PRPF4 | LIFR | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SCGB1D1 | LIFR | 25348397 | N/A | physical interaction | ComPPI |
| POU2F1 | LIFR | 25348397 | N/A | in vitro | ComPPI |
| DEFA1 | LIFR | 25348397 | N/A | physical interaction | ComPPI |
| LIFR | CNTFR | 11285233 11943154 12707266 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| LIFR | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
| LIFR | GOLT1B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PLCG1 | LIFR | 14525934 27898060 7512571 | N/A | experimental interaction detection | HPRD,OmniPath |
| SOCS3 | LIFR | 17312100 27898060 | inhibition | N/A | OmniPath |
| IL6ST | LIFR | 12047380 27898060 8999038 9716487 | N/A | N/A | OmniPath |
| LIFR | IL6ST | 12047380 24710148 27898060 8999038 | stimulant | N/A | OmniPath |
| LIF | LIFR | 12601009 16051226 24710148 27898060 8662595 8999038 9143707 9716487 9852103 | stimulant | N/A | OmniPath |
| MAPK3 | LIFR | 18624908 22306348 27898060 7777512 | inhibition | N/A | OmniPath |
| MAPK1 | LIFR | 27898060 7777512 | inhibition | N/A | OmniPath |
| CTF1 | LIFR | 11834704 27898060 | stimulant | N/A | OmniPath |
| TXK | LIFR | 27898060 7777512 | N/A | N/A | OmniPath |
| OSM | LIFR | 1536831 1542794 16051226 27898060 8999038 | stimulant | N/A | OmniPath |
| LIFR | CNTFR | 11285233 11943154 12707266 15051883 27898060 | N/A | N/A | OmniPath |
| CNTF | LIFR | 10207005 10966616 12643274 16051226 27898060 | stimulant | N/A | OmniPath |
| LIFR | CRLF1 | 10966616 27898060 | N/A | N/A | OmniPath |