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GENE：RFWD3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RFWD3
FullNmae ring finger and WD repeat domain 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25539
EnsembleID ENSG00000168411
Uniprot Q6PCD5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RFWD3 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RFWD3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RFWD3 GO:0000724,GO:0000724,GO:0002039,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0006974,GO:0010212,GO:0016567,GO:0016567,GO:0016567,GO:0016605,GO:0031297,GO:0031297,GO:0031571,GO:0035861,GO:0036297,GO:0046872,GO:0061630,GO:0061630,GO:0090734,GO:0090734,GO:0097371,GO:2000001

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR RFWD3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RFWD3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RFWD3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RFWD3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 RFWD3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RFWD3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RFWD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RFWD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RFWD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RFWD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RFWD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RFWD3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000007FBA RFWD3 20371350 23313552 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00000F31F4 RFWD3 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 RFWD3 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE RFWD3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003FD55 RFWD3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 RFWD3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002004E0 RFWD3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002E728C RFWD3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0B46 RFWD3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000076E54 RFWD3 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D RFWD3 20371350 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000043F369 RFWD3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006DA05 RFWD3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 RFWD3 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ATM RFWD3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
UBE2D1 RFWD3 19549727 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSP90AB1 RFWD3 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
UBE2E3 RFWD3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 RFWD3 19549727 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D2 RFWD3 19549727 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBB RFWD3 25348397 N/A physical interaction,comigration in sds page ComPPI
UBC RFWD3 25348397 N/A physical interaction,comigration in sds page ComPPI
RPS27A RFWD3 25348397 N/A physical interaction,comigration in sds page ComPPI
UBA52 RFWD3 25348397 N/A physical interaction,comigration in sds page ComPPI
HSP90AA1 RFWD3 25348397 N/A physical interaction ComPPI
UBE2N RFWD3 19549727 24234451 25260751 25348397 ubiquitination reaction,physical association two hybrid,physical interaction,two hybrid array,ubiquitinase assay ComPPI,IntAct
CANX RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA1 RFWD3 24126761 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HSP90B1 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DNAJB2 RFWD3 25348397 N/A physical interaction ComPPI
RAD51 RFWD3 25348397 N/A physical interaction ComPPI
XPO1 RFWD3 25348397 N/A physical interaction ComPPI
RPA2 RFWD3 24126761 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RPA3 RFWD3 24126761 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MDM2 RFWD3 20173098 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TCP1 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CCT5 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CCT7 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPH1 RFWD3 25348397 N/A physical interaction ComPPI
UBE2D3 RFWD3 19549727 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBA1 RFWD3 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
MBIP RFWD3 25348397 N/A physical interaction ComPPI
RNF41 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELAVL1 RFWD3 25348397 N/A physical interaction ComPPI
PFDN1 RFWD3 25348397 N/A physical interaction ComPPI
UBE2E1 RFWD3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2V1 RFWD3 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
PFDN2 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPD1 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP6V0D1 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LYAR RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIP4K2A RFWD3 25348397 N/A physical interaction ComPPI
GLG1 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CCT4 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CCT2 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CEP170 RFWD3 25348397 N/A physical interaction ComPPI
CCT6A RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2W RFWD3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCT8 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APP RFWD3 25348397 N/A physical interaction ComPPI
TP53 RFWD3 20173098 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CCT3 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NXF1 RFWD3 25348397 N/A physical interaction ComPPI
MOV10 RFWD3 25348397 N/A physical interaction ComPPI
HYOU1 RFWD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSP90AA2P RFWD3 25348397 N/A physical interaction ComPPI
RFWD3 COA1 25348397 N/A physical interaction ComPPI
RFWD3 LGR4 25348397 N/A physical interaction ComPPI
RFWD3 MBNL1 25348397 N/A physical interaction ComPPI
RFWD3 BBS7 25348397 N/A physical interaction ComPPI
RFWD3 CAMK1G 25348397 N/A physical interaction ComPPI
RFWD3 PRIMPOL 24126761 24234451 25348397 association tandem affinity purification ComPPI,IntAct
GOLGA4 RFWD3 24234451 30021884 physical association cross-linking study IntAct
ATR RFWD3 17478428 20173098 21558276 27898060 stimulant N/A OmniPath
ATM RFWD3 20173098 27898060 N/A N/A OmniPath

Visualization










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