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GENE：COX4I2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COX4I2
FullNmae cytochrome c oxidase subunit 4I2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16232
EnsembleID ENSG00000131055
Uniprot Q96KJ9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COX4I2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
COX4I2 GO:0004129,GO:0005751,GO:0005751,GO:0006091,GO:0006123,GO:0006123,GO:0045333,GO:1902600

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COX4I2 hsa:84701 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa01100 Metabolic pathways - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa04714 Thermogenesis - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa05010 Alzheimer disease - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa05012 Parkinson disease - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa05016 Huntington disease - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa05020 Prion disease - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
COX4I2 hsa:84701 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
COX5A COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
COX5B COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
COX6C COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
COX7B COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
COX7C COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
MT-CO1 COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
MT-CO3 COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
LONP1 COX4I2 12198491 17418790 26192618 interaction type N/A ACSN
HIF1A COX4I2 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 26192618 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 COX4I2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 COX4I2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 COX4I2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 COX4I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA COX4I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COX4I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 COX4I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COX4I2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CYCS COX4I2 25361965 interaction type N/A PTMCode2
COX4I2 CYCS 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CYCS COX4I2 10683230 11737208 1309738 14525934 2153405 25348397 6088481 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
COX4I2 APP 25348397 N/A physical interaction ComPPI
COX4I2 COA3 25348397 N/A physical interaction ComPPI
COX4I2 COX4I2 14525934 2986725 6088481 N/A experimental interaction detection HPRD
GOLGB1 COX4I2 24234451 30021884 physical association cross-linking study IntAct
H2BC9 COX4I2 24234451 30021884 physical association cross-linking study IntAct
H2BS1 COX4I2 24234451 30021884 physical association cross-linking study IntAct

Visualization










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