Gene Information gene info

  1. Home

GENE：TIMP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TIMP1
FullNmae TIMP metallopeptidase inhibitor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11820
EnsembleID ENSG00000102265
Uniprot P01033

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TIMP1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TIMP1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TIMP1 GO:0002020,GO:0002248,GO:0005125,GO:0005515,GO:0005576,GO:0005576,GO:0005604,GO:0005615,GO:0005615,GO:0005788,GO:0007165,GO:0008083,GO:0008191,GO:0008191,GO:0008270,GO:0008284,GO:0009725,GO:0010951,GO:0010951,GO:0030414,GO:0031012,GO:0031093,GO:0034097,GO:0043066,GO:0043086,GO:0043434,GO:0051045,GO:0051045,GO:0051216,GO:0070062,GO:0071492,GO:1901164,GO:1905049,GO:2001044

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TIMP1 hsa:7076 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TIMP1 MMP1 11279127 1629188 24174628 26192618 association N/A ACSN
SMAD3 TIMP1 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 TIMP1 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
STAT3 TIMP1 10347215 11528470 12223527 13130303 14607900 14670306 15218058 15356132 15573129 15810077 16418395 16716598 16831886 17403902 18297062 18776941 18832382 19380816 19412634 20093776 20237412 20406969 20581311 21317430 21840487 21883379 22006115 22943793 22945800 23124025 23454751 23953057 24857661 26192618 27216177 28186502 7543512 7768934 9278421 interaction type N/A ACSN
CD14 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
TIRAP TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
TIMP1 GATA1 16107690 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
YBX1 TIMP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 TIMP1 11830330 15048879 22415074 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SP3 TIMP1 11830330 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ASH1L TIMP1 22488473 trascriptional regulation,stimulation inferred by curator TFlink
FOSB TIMP1 10051488 11337499 trascriptional regulation,stimulation inferred by curator TFlink
FOSL2 TIMP1 11337499 trascriptional regulation,stimulation inferred by curator TFlink
JUND TIMP1 10051488 11337499 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TIMP1 11426939 14600595 trascriptional regulation,stimulation inferred by curator TFlink
PAX5 TIMP1 22105368 trascriptional regulation,stimulation inferred by curator TFlink
PPARD TIMP1 17511960 trascriptional regulation,stimulation inferred by curator TFlink
RELA TIMP1 14600595 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TIMP1 15051730 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 TIMP1 21128246 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 TIMP1 11830330 15048879 22415074 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 TIMP1 11918744 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 TIMP1 11918744 15161657 15920698 trascriptional regulation,stimulation inferred by curator TFlink
TWIST1 TIMP1 19513566 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS1 TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETV4 TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
FOS TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
HIF1A TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A TIMP1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 TIMP1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001DABC0 TIMP1 23943285 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000007F792 TIMP1 25416803 25998046 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 TIMP1 25416803 27012708 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000016FF9C TIMP1 25416803 27012708 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00005586D0 TIMP1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000016914 TIMP1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002C83DA TIMP1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F TIMP1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000024CEE0 TIMP1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005485E8 TIMP1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TIMP1 MMP2 25361965 interaction type N/A PTMCode2
MMP2 TIMP1 25361965 interaction type N/A PTMCode2
TIMP1 CD63 25361965 interaction type N/A PTMCode2
CD63 TIMP1 25361965 interaction type N/A PTMCode2
TIMP1 MMP20 25361965 interaction type N/A PTMCode2
MMP20 TIMP1 25361965 interaction type N/A PTMCode2
TIMP1 MMP3 25361965 interaction type N/A PTMCode2
MMP3 TIMP1 25361965 interaction type N/A PTMCode2
TIMP1 MMP14 25361965 interaction type N/A PTMCode2
MMP14 TIMP1 25361965 interaction type N/A PTMCode2
TIMP1 MMP1 25361965 interaction type N/A PTMCode2
MMP1 TIMP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MMP3 TIMP1 12475252 12834347 14525934 25348397 27898060 9288970 N/A experimental interaction detection,physical interaction,enzymatic study,in vitro ComPPI,HPRD,OmniPath
MMP14 TIMP1 25348397 N/A physical interaction ComPPI
FGFR2 TIMP1 25348397 N/A physical interaction ComPPI
ZBTB16 TIMP1 17340613 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SUMO2 TIMP1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TIMP1 MMP2 12475252 14525934 25348397 N/A experimental interaction detection,enzymatic study,in vitro ComPPI,HPRD
TIMP1 RECQL5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TIMP1 MYOC 14525934 16289162 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TIMP1 CD63 14525934 16917503 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,imaging technique,in vivo,two hybrid ComPPI,HPRD,IntAct
TIMP1 MMP1 14525934 25348397 9063449 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,enzymatic study ComPPI,HPRD
TIMP1 MMP9 24234451 24330623 25348397 physical association physical interaction,enzyme linked immunosorbent assay,protease assay,proximity ligation assay ComPPI,IntAct
TIMP1 COL5A1 20979576 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid ComPPI,IntAct
TIMP1 FBXO6 25348397 N/A physical interaction ComPPI
TIMP1 MMP10 25348397 N/A physical interaction ComPPI
TIMP1 IGFBP1 25348397 N/A physical interaction ComPPI
EEF1B2 TIMP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ECH1 TIMP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GNRHR TIMP1 17201186 27898060 inhibition N/A OmniPath
TWIST1 TIMP1 19513566 27898060 inhibition N/A OmniPath

Visualization










  Return