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GENE：CDKN2D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDKN2D
FullNmae cyclin dependent kinase inhibitor 2D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1790
EnsembleID ENSG00000129355
Uniprot P55273

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDKN2D parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN2D mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN2D immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN2D autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN2D apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN2D apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CDKN2D GO:0000079,GO:0000079,GO:0000731,GO:0004861,GO:0004861,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0007049,GO:0007605,GO:0008285,GO:0008285,GO:0009411,GO:0019901,GO:0019901,GO:0030308,GO:0032526,GO:0033280,GO:0042326,GO:0043154,GO:0048102,GO:0097129,GO:1902230,GO:1902807,GO:2000045,GO:2000045

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDKN2D hsa:1032 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
CDKN2D hsa:1032 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PML CDKN2D 23180781 25275592 physical association anti tag coimmunoprecipitation InnateDB
RARA CDKN2D 23180781 25275592 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CDKN2D 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CDKN2D 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CDKN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CDKN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CDKN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CDKN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CDKN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CDKN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RARA CDKN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CDKN2D N/A trascriptional regulation,stimulation inferred by curator TFlink
SP3 CDKN2D N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 CDKN2D 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 CDKN2D 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 CDKN2D 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001597DC CDKN2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002E857A CDKN2D 25416803 26019450 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA CDKN2D 22135298 phosphorylation N/A PhosphoSite
CDK2 CDKN2D 22135298 phosphorylation N/A PhosphoSite
CDK4 CDKN2D 25361965 interaction type N/A PTMCode2
CDKN2D CDK4 25361965 interaction type N/A PTMCode2
CDK6 CDKN2D 25361965 interaction type N/A PTMCode2
CDKN2D CDK6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF774 CDKN2D 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GATAD2B CDKN2D 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D CDK6 14525934 23602568 24234451 25348397 25416956 27107012 9751050 9751051 association,physical association two hybrid,experimental interaction detection,x-ray crystallography,physical interaction,two hybrid array,in vitro,tandem affinity purification,two hybrid prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CDKN2D HSD17B14 24234451 25348397 25416956 27107012 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
CDKN2D CDK4 14525934 16189514 23602568 24234451 25348397 25416956 25910212 27107012 7739548 association,physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CDKN2D TBC1D17 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CDKN2D BRCA1 25348397 N/A physical interaction ComPPI
CDKN2D APP 25348397 N/A physical interaction ComPPI
CDKN2D NR4A1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2D NR4A2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D IKZF3 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2D C1ORF94 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2D INCA1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2D HIF1AN 17003112 24234451 25348397 hydroxylation reaction hydroxylation reaction,hydroxylase assay ComPPI,IntAct
CDKN2D BTG1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
CDKN2D DYNLT2B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D PSMA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D GORASP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D ZNF688 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D SAXO1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D CGGBP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D SDCBP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D RUFY4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D PRDX5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D LONRF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D C5ORF49 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D TSGA10IP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D MSS51 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D PRIMPOL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D THAP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D PICK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D NDUFB7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D VGLL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D KRT75 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D NR4A3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D GSC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN1A CDKN2D 17287518 27898060 N/A N/A OmniPath
PRKACA CDKN2D 22558186 27898060 N/A N/A OmniPath
PRKCA CDKN2D 22558186 27898060 stimulant N/A OmniPath
CDKN2D CDK6 16915296 23602568 25416956 26186194 27898060 9751050 9751051 inhibition,stimulant N/A OmniPath
CDK2 CDKN2D 19063602 22558186 27898060 stimulant N/A OmniPath
MAP2K6 CDKN2D 10734227 27898060 N/A N/A OmniPath
CDKN2D CDK4 16189514 16915296 23602568 23718855 25416956 26186194 27898060 7739548 inhibition,stimulant N/A OmniPath

Visualization










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