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GENE：ACSL3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACSL3
FullNmae acyl-CoA synthetase long chain family member 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3570
EnsembleID ENSG00000123983
Uniprot O95573

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACSL3 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACSL3 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ACSL3 GO:0001676,GO:0001676,GO:0001676,GO:0004467,GO:0004467,GO:0004467,GO:0004467,GO:0005515,GO:0005524,GO:0005741,GO:0005778,GO:0005783,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0005811,GO:0005886,GO:0006631,GO:0016020,GO:0019901,GO:0019904,GO:0030182,GO:0031956,GO:0034379,GO:0035336,GO:0035338,GO:0042998,GO:0044539,GO:0047676,GO:0048471,GO:0051047,GO:0090433,GO:2001247

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACSL3 hsa:2181 path:hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
ACSL3 hsa:2181 path:hsa00071 Fatty acid degradation - Homo sapiens (human)
ACSL3 hsa:2181 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACSL3 hsa:2181 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)
ACSL3 hsa:2181 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)
ACSL3 hsa:2181 path:hsa04146 Peroxisome - Homo sapiens (human)
ACSL3 hsa:2181 path:hsa04216 Ferroptosis - Homo sapiens (human)
ACSL3 hsa:2181 path:hsa04714 Thermogenesis - Homo sapiens (human)
ACSL3 hsa:2181 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STING1 ACSL3 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACSL3 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 ACSL3 23180781 23798571 physical association affinity chromatography technology InnateDB

Source Target Pmid Interactiontype Methods Database
AR ACSL3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 ACSL3 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 ACSL3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ACSL3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 ACSL3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 ACSL3 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ACSL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
JUN ACSL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 ACSL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A ACSL3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ACSL3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000007FBA ACSL3 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000ED600 ACSL3 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000170CF4 ACSL3 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00001A405B ACSL3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000007F792 ACSL3 22100165 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 ACSL3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C ACSL3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000008C563 ACSL3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 ACSL3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 ACSL3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 ACSL3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 ACSL3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E ACSL3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 ACSL3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 ACSL3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000C0D3F ACSL3 25416803 25961460 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
YES1 ACSL3 25348397 N/A physical interaction ComPPI
LMNA ACSL3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MCM2 ACSL3 25348397 N/A physical interaction ComPPI
HIPK4 ACSL3 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ERBB2 ACSL3 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
LYN ACSL3 20605918 25348397 27898060 N/A physical interaction ComPPI,OmniPath
JUN ACSL3 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
GTF2F2 ACSL3 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SPART ACSL3 19765186 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NTRK1 ACSL3 25348397 N/A physical interaction ComPPI
CANX ACSL3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CFTR ACSL3 25348397 N/A physical interaction ComPPI
EVC2 ACSL3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MAPK6 ACSL3 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
NDRG1 ACSL3 14525934 17220478 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
EGFR ACSL3 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CUL7 ACSL3 25348397 N/A physical interaction ComPPI
TRIM25 ACSL3 25348397 N/A physical interaction ComPPI
KIF20B ACSL3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ESRRB ACSL3 25348397 N/A physical interaction ComPPI
PPEF1 ACSL3 24234451 25348397 28330616 association pull down ComPPI,IntAct
TES ACSL3 25348397 N/A physical interaction ComPPI
IFT140 ACSL3 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
KIF11 ACSL3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CYLD ACSL3 25348397 N/A physical interaction ComPPI
PPP6R2 ACSL3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SKA1 ACSL3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK4 ACSL3 25348397 N/A physical interaction ComPPI
PLGRKT ACSL3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SIRT7 ACSL3 25348397 N/A physical interaction ComPPI
TMEM216 ACSL3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LAMP1 ACSL3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
APP ACSL3 25348397 N/A physical interaction ComPPI
MTHFD1 ACSL3 25348397 N/A physical interaction ComPPI
PPP6R1 ACSL3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OBSL1 ACSL3 25348397 N/A physical interaction ComPPI
STING1 ACSL3 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACSL4 ACSL3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACSL3 STAU1 25348397 N/A physical interaction ComPPI
ACSL3 CCDC8 25348397 N/A physical interaction ComPPI
ACSL3 GNAT2 25348397 N/A physical interaction ComPPI
ACSL3 TCTN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ACSL3 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ACSL3 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ACSL3 REEP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACSL3 TIGD6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACSL3 MTMR14 25348397 N/A physical interaction ComPPI
ACSL3 TPTE 25348397 N/A physical interaction ComPPI
ACSL3 WDR19 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
ACSL3 C15ORF40 24234451 30021884 physical association cross-linking study IntAct
ACSL3 DDX42 24234451 30021884 physical association cross-linking study IntAct
ACSL3 DOCK11 24234451 30021884 physical association cross-linking study IntAct
TTBK1 ACSL3 24234451 30021884 physical association cross-linking study IntAct
STING1 ACSL3 21903422 27898060 N/A N/A OmniPath

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