Gene Information gene info

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GENE：ACSL6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACSL6
FullNmae acyl-CoA synthetase long chain family member 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16496
EnsembleID ENSG00000164398
Uniprot Q9UKU0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACSL6 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACSL6 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ACSL6 GO:0000038,GO:0001676,GO:0001676,GO:0001676,GO:0004467,GO:0004467,GO:0004467,GO:0004467,GO:0005524,GO:0005741,GO:0005778,GO:0005783,GO:0005783,GO:0005789,GO:0005886,GO:0006637,GO:0007405,GO:0016020,GO:0035338,GO:0035338,GO:0042803,GO:0047676,GO:0047676

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACSL6 hsa:23305 path:hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
ACSL6 hsa:23305 path:hsa00071 Fatty acid degradation - Homo sapiens (human)
ACSL6 hsa:23305 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACSL6 hsa:23305 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)
ACSL6 hsa:23305 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)
ACSL6 hsa:23305 path:hsa04146 Peroxisome - Homo sapiens (human)
ACSL6 hsa:23305 path:hsa04216 Ferroptosis - Homo sapiens (human)
ACSL6 hsa:23305 path:hsa04714 Thermogenesis - Homo sapiens (human)
ACSL6 hsa:23305 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ACSL6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ACSL6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ACSL6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ACSL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 ACSL6 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000086A4D ACSL6 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D ACSL6 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 ACSL6 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002F3336 ACSL6 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC ACSL6 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 ACSL6 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 ACSL6 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A ACSL6 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000450F92 ACSL6 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E ACSL6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 ACSL6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F ACSL6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD ACSL6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000038446A ACSL6 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PHYH ACSL6 25361965 interaction type N/A PTMCode2
ACSL6 PHYH 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PHYH ACSL6 12767919 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ZNF16 ACSL6 21874239 24234451 25348397 physical association two hybrid ComPPI,IntAct

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