GENE：AIFM2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AIFM2 |
| FullNmae | apoptosis inducing factor mitochondria associated 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:21411 |
| EnsembleID | ENSG00000042286 |
| Uniprot | Q9BRQ8 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AIFM2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AIFM2 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AIFM2 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AIFM2 | GO:0003677,GO:0004174,GO:0004174,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005737,GO:0005739,GO:0005739,GO:0005741,GO:0005741,GO:0005811,GO:0005829,GO:0005886,GO:0006743,GO:0008637,GO:0008637,GO:0016655,GO:0022904,GO:0042373,GO:0043065,GO:0043065,GO:0050660,GO:0050660,GO:0110076,GO:0110076,GO:1900407,GO:1990748 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AIFM2 | hsa:84883 | path:hsa04115 | p53 signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | AIFM2 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | AIFM2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP53 | AIFM2 | 12135761 15273740 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | AIFM2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | AIFM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AIFM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | AIFM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AIFM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | AIFM2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000821E0 | AIFM2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000041CB9C | AIFM2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000016FD1A | AIFM2 | 22815788 23824327 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr,clip | TarBase |
| URS00005E1A16 | AIFM2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000140295 | AIFM2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BA274 | AIFM2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004B4B85 | AIFM2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004BACE | AIFM2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000047944F | AIFM2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000239117 | AIFM2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D0874 | AIFM2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000083D87 | AIFM2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | AIFM2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB14 | AIFM2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000148B91 | AIFM2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000435A77 | AIFM2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000160683 | AIFM2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F3336 | AIFM2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000521626 | AIFM2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MYC | AIFM2 | 21150319 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| TRIM54 | AIFM2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| USE1 | AIFM2 | 19369418 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| TP53 | AIFM2 | 25348397 | N/A | physical interaction | ComPPI |
| NDUFA4 | AIFM2 | 25348397 | N/A | physical interaction | ComPPI |
| TP53 | AIFM2 | 1588974 27898060 | stimulant | N/A | OmniPath |