GENE：AKR1C2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AKR1C2 |
| FullNmae | aldo-keto reductase family 1 member C2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:385 |
| EnsembleID | ENSG00000151632 |
| Uniprot | P52895 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AKR1C2 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AKR1C2 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AKR1C2 | GO:0004032,GO:0004032,GO:0004303,GO:0005829,GO:0006693,GO:0006693,GO:0007186,GO:0007586,GO:0008202,GO:0008284,GO:0016655,GO:0018636,GO:0030855,GO:0031406,GO:0032052,GO:0032052,GO:0042448,GO:0042448,GO:0044597,GO:0044597,GO:0044598,GO:0044598,GO:0047023,GO:0047044,GO:0047086,GO:0047086,GO:0047115,GO:0047718,GO:0051897,GO:0071395,GO:0071799 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AKR1C2 | hsa:1646 | path:hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| AKR1C2 | hsa:1646 | path:hsa05204 | Chemical carcinogenesis - DNA adducts - Homo sapiens (human) |
| AKR1C2 | hsa:1646 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | AKR1C2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| NFE2 | AKR1C2 | 16478829 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | AKR1C2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | AKR1C2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AKR1C2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AKR1C2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TWIST1 | AKR1C2 | 19051271 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TWIST2 | AKR1C2 | 19051271 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU2F1 | AKR1C2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000AA464 | AKR1C2 | 21512034 | rna interference,inhibition | experimental interaction detection,miRNA interference luciferase reporter assay | miRSponge |
| URS00000AA464 | AKR1C2 | 21512034 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IPO8 | AKR1C2 | 25348397 | N/A | physical interaction | ComPPI |
| SOD1 | AKR1C2 | 25348397 | N/A | physical interaction | ComPPI |
| LAMTOR5 | AKR1C2 | 23414517 24234451 25348397 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| MIF | AKR1C2 | 25348397 | N/A | physical interaction | ComPPI |
| TKT | AKR1C2 | 25348397 | N/A | physical interaction | ComPPI |