GENE：AKR1C3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AKR1C3 |
| FullNmae | aldo-keto reductase family 1 member C3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:386 |
| EnsembleID | ENSG00000196139 |
| Uniprot | P42330 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AKR1C3 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AKR1C3 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| AKR1C3 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AKR1C3 | GO:0001523,GO:0001758,GO:0004032,GO:0004032,GO:0004033,GO:0004033,GO:0004303,GO:0004745,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0006693,GO:0006693,GO:0006693,GO:0007186,GO:0007584,GO:0008202,GO:0008284,GO:0008284,GO:0008584,GO:0009267,GO:0016488,GO:0016655,GO:0018636,GO:0019371,GO:0030216,GO:0032052,GO:0035410,GO:0036130,GO:0036131,GO:0042448,GO:0042448,GO:0042572,GO:0042574,GO:0043170,GO:0044597,GO:0044597,GO:0044598,GO:0044598,GO:0045550,GO:0045703,GO:0047017,GO:0047020,GO:0047023,GO:0047023,GO:0047024,GO:0047035,GO:0047044,GO:0047045,GO:0047086,GO:0047086,GO:0047787,GO:0048385,GO:0051897,GO:0052650,GO:0061370,GO:0070062,GO:0070293,GO:0071277,GO:0071379,GO:0071384,GO:0071395,GO:0071799,GO:1900053,GO:2000224,GO:2000353,GO:2000379 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AKR1C3 | hsa:8644 | path:hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| AKR1C3 | hsa:8644 | path:hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| AKR1C3 | hsa:8644 | path:hsa00790 | Folate biosynthesis - Homo sapiens (human) |
| AKR1C3 | hsa:8644 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| AKR1C3 | hsa:8644 | path:hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| AKR1C3 | hsa:8644 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | AKR1C3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | AKR1C3 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | AKR1C3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | AKR1C3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AKR1C3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AKR1C3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AKR1C3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | AKR1C3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | AKR1C3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AR | AKR1C3 | 22971343 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU2F1 | AKR1C3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SIAH2 | AKR1C3 | 25348397 | N/A | physical interaction | ComPPI |
| ZHX1 | AKR1C3 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| ACIN1 | AKR1C3 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| RIF1 | AKR1C3 | 16169070 24234451 25348397 | physical association | two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| MAGEA11 | AKR1C3 | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| AKR1C3 | UBE2W | 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |