GENE：DTL
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DTL |
| FullNmae | denticleless E3 ubiquitin protein ligase homolog |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:30288 |
| EnsembleID | ENSG00000143476 |
| Uniprot | Q9NZJ0 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DTL | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DTL | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DTL | GO:0000209,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005694,GO:0005730,GO:0005813,GO:0005829,GO:0006260,GO:0006511,GO:0006511,GO:0006511,GO:0006513,GO:0006974,GO:0006974,GO:0007095,GO:0007095,GO:0009411,GO:0010971,GO:0019985,GO:0030674,GO:0031464,GO:0031465,GO:0031965,GO:0043161,GO:0045732,GO:0048511,GO:0051726,GO:0080008 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DTL | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | DTL | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | DTL | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | DTL | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | DTL | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | DTL | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | DTL | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DTL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DTL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DTL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | DTL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DTL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DTL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DTL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | DTL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | DTL | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000B59A2 | DTL | 19074876 | rna interference,inhibition | array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000065D58 | DTL | 22287560 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00000B59A2 | DTL | 19074876 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000065D58 | DTL | 22287560 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000F31F4 | DTL | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | DTL | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000040780F | DTL | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000285DCB | DTL | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDK1 | DTL | 22135298 | phosphorylation | N/A | PhosphoSite |
| CDK2 | DTL | 22135298 | phosphorylation | N/A | PhosphoSite |
| DDB1 | DTL | 25361965 | interaction type | N/A | PTMCode2 |
| DTL | DDB1 | 25361965 | interaction type | N/A | PTMCode2 |
| CDKN1A | DTL | 25361965 | interaction type | N/A | PTMCode2 |
| DTL | CDKN1A | 25361965 | interaction type | N/A | PTMCode2 |
| DTL | CUL4A | 25361965 | interaction type | N/A | PTMCode2 |
| CUL4A | DTL | 25361965 | interaction type | N/A | PTMCode2 |
| DTL | CUL4B | 25361965 | interaction type | N/A | PTMCode2 |
| CUL4B | DTL | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBE2I | DTL | 25348397 | N/A | physical interaction | ComPPI |
| ZNRD2 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| PCNA | DTL | 25348397 | N/A | physical interaction | ComPPI |
| CDKN1A | DTL | 25348397 | N/A | physical interaction | ComPPI |
| YWHAG | DTL | 25348397 | N/A | physical interaction | ComPPI |
| UBE2D1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| UBE2E2 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| UBE2E3 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| TOB1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| LYN | DTL | 25348397 | N/A | physical interaction | ComPPI |
| ATR | DTL | 25348397 | N/A | physical interaction | ComPPI |
| TDG | DTL | 25348397 | N/A | physical interaction | ComPPI |
| COPS5 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| RBX1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| YWHAB | DTL | 25348397 | N/A | physical interaction | ComPPI |
| YWHAZ | DTL | 25348397 | N/A | physical interaction | ComPPI |
| TUBG1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| UBE2N | DTL | 25348397 | N/A | physical interaction | ComPPI |
| MSH6 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| CFTR | DTL | 25348397 | N/A | physical interaction | ComPPI |
| RAD18 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| YWHAQ | DTL | 25348397 | N/A | physical interaction | ComPPI |
| COPS2 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| CAMK2D | DTL | 25348397 | N/A | physical interaction | ComPPI |
| CUL4B | DTL | 17041588 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MDM2 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| CHEK1 | DTL | 23109433 23533280 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| CUL4A | DTL | 17041588 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| YWHAH | DTL | 25348397 | N/A | physical interaction | ComPPI |
| SFN | DTL | 25348397 | N/A | physical interaction | ComPPI |
| YWHAE | DTL | 25348397 | N/A | physical interaction | ComPPI |
| GLMN | DTL | 25348397 | N/A | physical interaction | ComPPI |
| CCT7 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| HSPA4 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| KAT2A | DTL | 25348397 | N/A | physical interaction | ComPPI |
| COPS3 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| COPS4 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| GPS1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| COPS6 | DTL | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| COPS7A | DTL | 25348397 | N/A | physical interaction | ComPPI |
| COPS8 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| ERCC5 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| DDB1 | DTL | 17041588 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,in vivo | ComPPI,IntAct |
| CDT1 | DTL | 16861906 21930785 24906324 25348397 26272819 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| FBH1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| UBE2E1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| AURKB | DTL | 25348397 | N/A | physical interaction | ComPPI |
| HLTF | DTL | 25348397 | N/A | physical interaction | ComPPI |
| PFDN2 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| TCEAL1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| WDR5 | DTL | 17041588 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KMT5A | DTL | 25348397 | N/A | physical interaction | ComPPI |
| SHPRH | DTL | 25348397 | N/A | physical interaction | ComPPI |
| MSH2 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| GATD1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| DTL | TP53 | 25348397 | N/A | physical interaction | ComPPI |
| DTL | FBXO11 | 25348397 | N/A | physical interaction | ComPPI |
| DTL | CARNMT1 | 25348397 | N/A | physical interaction | ComPPI |
| DTL | BIVM | 25348397 | N/A | physical interaction | ComPPI |
| DTL | NSD2 | 25348397 | N/A | physical interaction | ComPPI |
| DTL | POLD4 | 25348397 | N/A | physical interaction | ComPPI |
| DTL | CCT3 | 25348397 | N/A | physical interaction | ComPPI |
| DTL | DEF8 | 25348397 | N/A | physical interaction | ComPPI |
| DTL | GRWD1 | 17041588 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| DDA1 | DTL | 25348397 | N/A | physical interaction | ComPPI |
| DTL | KMT5A | 20932471 20932472 21035370 21220508 27898060 | inhibition | N/A | OmniPath |
| E2F1 | DTL | 18213392 27898060 | stimulant | N/A | OmniPath |
| CDK1 | DTL | 25154416 27898060 | N/A | N/A | OmniPath |
| DTL | CUL4A | 16949367 17041588 21145461 23478441 23555860 27898060 | stimulant | N/A | OmniPath |
| FBXO11 | DTL | 23478441 25154416 27898060 | inhibition | N/A | OmniPath |