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GENE：FDFT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FDFT1
FullNmae farnesyl-diphosphate farnesyltransferase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3629
EnsembleID ENSG00000079459
Uniprot P37268

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FDFT1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FDFT1 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FDFT1 GO:0004310,GO:0005515,GO:0005783,GO:0005789,GO:0005789,GO:0005789,GO:0006694,GO:0006695,GO:0016020,GO:0045338,GO:0046872,GO:0051996

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FDFT1 hsa:2222 path:hsa00100 Steroid biosynthesis - Homo sapiens (human)
FDFT1 hsa:2222 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 FDFT1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 FDFT1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 FDFT1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FDFT1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 FDFT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FDFT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FDFT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FDFT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FDFT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 FDFT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR FDFT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 FDFT1 11008488 11111077 trascriptional regulation,stimulation inferred by curator TFlink
SREBF2 FDFT1 11008488 11111077 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 FDFT1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 FDFT1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 FDFT1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000512C88 FDFT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D FDFT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000821E0 FDFT1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C48FA FDFT1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004CCA62 FDFT1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041FA2C FDFT1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LMNA FDFT1 25348397 N/A physical interaction ComPPI
ITGB5 FDFT1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RUVBL1 FDFT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK6 FDFT1 24234451 25348397 29426014 association anti tag coimmunoprecipitation ComPPI,IntAct
SYVN1 FDFT1 25348397 N/A physical interaction ComPPI
SMNDC1 FDFT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR FDFT1 25348397 N/A physical interaction ComPPI
PSTPIP1 FDFT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CREB3 FDFT1 25348397 N/A two hybrid bait and prey pooling approach ComPPI
HDAC10 FDFT1 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
P2RX4 FDFT1 25348397 N/A physical interaction ComPPI
PTP4A1 FDFT1 25348397 N/A physical interaction ComPPI
DUSP6 FDFT1 25348397 N/A physical interaction ComPPI
RUVBL2 FDFT1 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UCHL5 FDFT1 25348397 N/A physical interaction ComPPI
SERPINA4 FDFT1 25348397 N/A physical interaction ComPPI
ANXA5 FDFT1 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PNKD FDFT1 25348397 N/A physical interaction ComPPI
SHPRH FDFT1 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SRPRB FDFT1 25348397 N/A physical interaction ComPPI
FBXO6 FDFT1 25348397 N/A physical interaction ComPPI
PANX1 FDFT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FN1 FDFT1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
FDFT1 UNC93B1 25348397 N/A physical interaction ComPPI
FDFT1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
NUP205 FDFT1 24234451 30021884 physical association cross-linking study IntAct
HNRNPM FDFT1 24234451 30021884 physical association cross-linking study IntAct

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