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GENE：GCH1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GCH1
FullNmae GTP cyclohydrolase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4193
EnsembleID ENSG00000131979
Uniprot P30793

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GCH1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GCH1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GCH1 GO:0003924,GO:0003934,GO:0003934,GO:0005509,GO:0005515,GO:0005525,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006729,GO:0006729,GO:0006729,GO:0006809,GO:0008217,GO:0008270,GO:0008270,GO:0010460,GO:0014916,GO:0030742,GO:0031369,GO:0031410,GO:0031965,GO:0032496,GO:0032991,GO:0034341,GO:0034612,GO:0035998,GO:0042311,GO:0042416,GO:0042559,GO:0042802,GO:0042803,GO:0044306,GO:0044877,GO:0045776,GO:0046654,GO:0048265,GO:0050884,GO:0051000,GO:0051000,GO:0051019,GO:0065003,GO:2000121

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GCH1 hsa:2643 path:hsa00790 Folate biosynthesis - Homo sapiens (human)
GCH1 hsa:2643 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GCH1 hsa:2643 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GCH1 CSNK2A1 19294699 23180781 physical association anti tag coimmunoprecipitation InnateDB
GCH1 MAPK12 19294699 23180781 physical association anti tag coimmunoprecipitation InnateDB
GCH1 MAPK10 19294699 23180781 physical association anti tag coimmunoprecipitation InnateDB
GCH1 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB
GCH1 YWHAZ 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 GCH1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 GCH1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GCH1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 GCH1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GCH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GCH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GCH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GCH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GCH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GCH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GCH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GCH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 GCH1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 GCH1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 GCH1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 GCH1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000035CC3E GCH1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000753AD GCH1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD GCH1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE GCH1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC GCH1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GCHFR GCH1 25361965 interaction type N/A PTMCode2
GCH1 GCHFR 25361965 interaction type N/A PTMCode2
TH GCH1 25361965 interaction type N/A PTMCode2
GCH1 TH 25361965 interaction type N/A PTMCode2
AHSA1 GCH1 25361965 interaction type N/A PTMCode2
GCH1 AHSA1 25361965 interaction type N/A PTMCode2
TPH1 GCH1 25361965 interaction type N/A PTMCode2
GCH1 TPH1 25361965 interaction type N/A PTMCode2
GCH1 RPH3A 25361965 interaction type N/A PTMCode2
RPH3A GCH1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSPA8 GCH1 14525934 16696853 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PACSIN3 GCH1 25348397 N/A physical interaction ComPPI
PRKAR2B GCH1 25348397 N/A physical interaction ComPPI
RPH3A GCH1 14525934 25348397 27898060 7802677 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
YWHAZ GCH1 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,confocal microscopy ComPPI,IntAct
MAP2K4 GCH1 25348397 N/A physical interaction ComPPI
CSNK2A1 GCH1 25348397 N/A physical interaction ComPPI
PRKAR2A GCH1 25348397 N/A physical interaction ComPPI
RGS19 GCH1 25348397 N/A physical interaction ComPPI
MAP2K5 GCH1 25348397 N/A physical interaction ComPPI
SP3 GCH1 16696853 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RLF GCH1 14525934 16696853 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ATP1B1 GCH1 14525934 16696853 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MAPK10 GCH1 25348397 N/A physical interaction ComPPI
MAPK12 GCH1 25348397 N/A physical interaction ComPPI
GIT2 GCH1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SH3GL2 GCH1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPM1B GCH1 25348397 N/A physical interaction ComPPI
CDC37 GCH1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GCHFR GCH1 14525934 16696853 24234451 25348397 8702680 physical association two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
GCH1 AHSA1 14525934 16696853 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
GCH1 RAB26 14525934 16696853 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GCH1 OSBPL9 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GCH1 CNRIP1 16696853 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GCH1 CALML5 25348397 N/A physical interaction ComPPI
GCH1 CALML6 25348397 N/A physical interaction ComPPI
GCH1 CAMKK1 25348397 N/A physical interaction ComPPI
GCH1 CSNK1G1 25348397 N/A physical interaction ComPPI
GCH1 CSNK2B 25348397 N/A physical interaction ComPPI
GCH1 TNPO3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GCH1 GCH1 11087827 14525934 16696853 24234451 physical association two hybrid,experimental interaction detection HPRD,IntAct
RPS12 GCH1 24234451 30021884 physical association cross-linking study IntAct
UBC GCH1 22984419 27898060 N/A N/A OmniPath
HSPB1 GCH1 18241680 27898060 stimulant N/A OmniPath
GCHFR GCH1 11361142 16696853 27898060 8702680 9092499 9685352 inhibition N/A OmniPath
AHSA1 GCH1 16696853 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B7A38 GCH1 27087310 direct interaction,inhibition N/A NPInter

Visualization










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