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GENE：GSS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GSS
FullNmae glutathione synthetase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4624
EnsembleID ENSG00000100983
Uniprot P48637

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GSS immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GSS ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GSS ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GSS cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
GSS cuproptosis 36118866 Inhibitor cuproptosis gene

Go Annotation:

GeneSymbol Go id
GSS GO:0000287,GO:0004363,GO:0005515,GO:0005524,GO:0005829,GO:0005829,GO:0006520,GO:0006750,GO:0006979,GO:0007399,GO:0042802,GO:0042803,GO:0043295,GO:0043295,GO:0046686,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GSS hsa:2937 path:hsa00270 Cysteine and methionine metabolism - Homo sapiens (human)
GSS hsa:2937 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
GSS hsa:2937 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GSS hsa:2937 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)
GSS hsa:2937 path:hsa04216 Ferroptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 GSS 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 GSS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GSS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GSS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GSS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GSS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GSS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GSS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GSS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GSS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFE2 GSS 15890065 trascriptional regulation,stimulation inferred by curator TFlink
NFE2L2 GSS 15890065 22213475 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001A7F58 GSS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 GSS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC GSS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000002569A GSS 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF GSS 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 GSS 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 GSS 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 GSS 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C GSS 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GSS GCLC 25361965 interaction type N/A PTMCode2
GCLC GSS 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YWHAG GSS 25348397 N/A physical interaction ComPPI
TBCB GSS 25348397 N/A physical interaction ComPPI
RAP1GDS1 GSS 25348397 N/A physical interaction ComPPI
YWHAB GSS 25348397 N/A physical interaction ComPPI
GAPDH GSS 18309294 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IRF3 GSS 18309294 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDIA4 GSS 25348397 N/A physical interaction ComPPI
VCL GSS 25348397 N/A physical interaction ComPPI
YWHAH GSS 25348397 N/A physical interaction ComPPI
YWHAE GSS 25348397 N/A physical interaction ComPPI
MSN GSS 25348397 N/A physical interaction ComPPI
CDK9 GSS 25348397 N/A physical interaction ComPPI
ASS1 GSS 25348397 N/A physical interaction ComPPI
PPP5C GSS 25348397 N/A physical interaction ComPPI
TERF1 GSS 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
ZFAND6 GSS 25348397 N/A physical interaction ComPPI
PAFAH1B2 GSS 25348397 N/A physical interaction ComPPI
RRAGB GSS 25348397 N/A physical interaction ComPPI
ECHS1 GSS 25348397 N/A physical interaction ComPPI
MVK GSS 25348397 N/A physical interaction ComPPI
GSS GSTZ1 14525934 15173170 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
GSS ABHD14A 25348397 N/A physical interaction ComPPI
GSS GINS3 25348397 N/A physical interaction ComPPI
GSS ASNS 25348397 N/A physical interaction ComPPI
GSS OLA1 25348397 N/A physical interaction ComPPI
GSS USP14 25348397 N/A physical interaction ComPPI
GSS GBE1 25348397 N/A physical interaction ComPPI
HMGB3 GSS 25348397 N/A physical interaction ComPPI
DCPS GSS 25348397 N/A physical interaction ComPPI
GSS GSS 14525934 21988832 24234451 25416956 26871637 7646467 physical association two hybrid,experimental interaction detection,two hybrid array,two hybrid prey pooling approach,validated two hybrid HPRD,IntAct

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