GENE:HMGCR
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | HMGCR |
FullNmae | 3-hydroxy-3-methylglutaryl-CoA reductase |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:5006 |
EnsembleID | ENSG00000113161 |
Uniprot | P04035 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
HMGCR | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
HMGCR | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
HMGCR | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
HMGCR | GO:0004420,GO:0004420,GO:0005515,GO:0005778,GO:0005778,GO:0005783,GO:0005789,GO:0005789,GO:0006695,GO:0008299,GO:0008542,GO:0015936,GO:0016126,GO:0030695,GO:0042177,GO:0050709,GO:0060291,GO:0070372,GO:0070402,GO:0120225,GO:1900222 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
HMGCR | hsa:3156 | path:hsa00900 | Terpenoid backbone biosynthesis - Homo sapiens (human) |
HMGCR | hsa:3156 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
HMGCR | hsa:3156 | path:hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
HMGCR | hsa:3156 | path:hsa04976 | Bile secretion - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | HMGCR | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ETS1 | HMGCR | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA1 | HMGCR | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | HMGCR | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA3 | HMGCR | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
YBX1 | HMGCR | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
SMARCA4 | HMGCR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | HMGCR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | HMGCR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | HMGCR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | HMGCR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | HMGCR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | HMGCR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TRIM28 | HMGCR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
VDR | HMGCR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SREBF2 | HMGCR | 17448444 19288057 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00000AA464 | HMGCR | 20304954 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000237AF9 | HMGCR | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000272A3D | HMGCR | 20371350 25416803 28112179 | mrna cleavage,inhibition | nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00002FC5B0 | HMGCR | 20371350 22473208 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
URS00003D5391 | HMGCR | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00001A7F58 | HMGCR | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000085F64 | HMGCR | 19536157 23824327 24906430 25416803 27418678 28735896 | mrna cleavage,inhibition | clip | TarBase |
URS000076B539 | HMGCR | 19536157 23824327 24906430 25416803 27418678 28735896 | mrna cleavage,inhibition | clip | TarBase |
URS0000072E4C | HMGCR | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000018CD09 | HMGCR | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075E2C3 | HMGCR | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000076995 | HMGCR | 25416803 26246194 28112179 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00001B341F | HMGCR | 25416803 26646011 | mrna cleavage,inhibition | nucleotide sequence identification,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
HMGCR | INSIG1 | 25361965 | interaction type | N/A | PTMCode2 |
INSIG1 | HMGCR | 25361965 | interaction type | N/A | PTMCode2 |
HMGCR | FDPS | 25361965 | interaction type | N/A | PTMCode2 |
FDPS | HMGCR | 25361965 | interaction type | N/A | PTMCode2 |
HMGCR | HMGCR | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
VCP | HMGCR | 21343306 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
DCUN1D1 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
INSIG2 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
PRKACA | HMGCR | 14525934 2369897 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
ARHGAP1 | HMGCR | 14525934 14697242 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
UBC | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
PTGIR | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
STARD13 | HMGCR | 14525934 14697242 24234451 25348397 | physical association | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD,IntAct |
SYVN1 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
AUP1 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
RNF139 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
INSIG1 | HMGCR | 12535518 14525934 16168377 19458199 20458442 21343306 23223569 24371122 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
AMFR | HMGCR | 21343306 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
KCNS3 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
FAF2 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
SPINT2 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
FAM189A2 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
SRPRB | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
LPAR1 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
CD209 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | ERLIN2 | 21343306 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
HMGCR | RIC3 | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | ATP1B3 | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | KCNK16 | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | TMEM30A | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | BTN2A1 | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | HEPACAM2 | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | CHRNA9 | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | UNK | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | TCTN3 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
HMGCR | UBIAD1 | 23169578 24234451 25348397 | colocalization,physical association | anti tag coimmunoprecipitation,physical interaction,confocal microscopy | ComPPI,IntAct |
HMGCR | GABRA6 | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | ADGRG5 | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
B3GAT3 | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
HMGCR | HMGCR | 10698924 14525934 | N/A | experimental interaction detection | HPRD |
PRKACA | HMGCR | 2369897 27898060 | N/A | N/A | OmniPath |