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GENE：HMGCR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HMGCR
FullNmae 3-hydroxy-3-methylglutaryl-CoA reductase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5006
EnsembleID ENSG00000113161
Uniprot P04035

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HMGCR mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMGCR ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMGCR ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HMGCR GO:0004420,GO:0004420,GO:0005515,GO:0005778,GO:0005778,GO:0005783,GO:0005789,GO:0005789,GO:0006695,GO:0008299,GO:0008542,GO:0015936,GO:0016126,GO:0030695,GO:0042177,GO:0050709,GO:0060291,GO:0070372,GO:0070402,GO:0120225,GO:1900222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HMGCR hsa:3156 path:hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human)
HMGCR hsa:3156 path:hsa01100 Metabolic pathways - Homo sapiens (human)
HMGCR hsa:3156 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
HMGCR hsa:3156 path:hsa04976 Bile secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STARD13 HMGCR 14697242 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR HMGCR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 HMGCR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HMGCR 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HMGCR 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 HMGCR 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 HMGCR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 HMGCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HMGCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HMGCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HMGCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HMGCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HMGCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HMGCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HMGCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR HMGCR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SREBF2 HMGCR 17448444 19288057 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 HMGCR 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000237AF9 HMGCR 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000272A3D HMGCR 20371350 25416803 28112179 mrna cleavage,inhibition nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002FC5B0 HMGCR 20371350 22473208 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00003D5391 HMGCR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 HMGCR 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 HMGCR 19536157 23824327 24906430 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000076B539 HMGCR 19536157 23824327 24906430 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000072E4C HMGCR 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 HMGCR 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 HMGCR 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 HMGCR 25416803 26246194 28112179 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001B341F HMGCR 25416803 26646011 mrna cleavage,inhibition nucleotide sequence identification,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
HMGCR INSIG1 25361965 interaction type N/A PTMCode2
INSIG1 HMGCR 25361965 interaction type N/A PTMCode2
HMGCR FDPS 25361965 interaction type N/A PTMCode2
FDPS HMGCR 25361965 interaction type N/A PTMCode2
HMGCR HMGCR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VCP HMGCR 21343306 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DCUN1D1 HMGCR 25348397 N/A physical interaction ComPPI
INSIG2 HMGCR 25348397 N/A physical interaction ComPPI
PRKACA HMGCR 14525934 2369897 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ARHGAP1 HMGCR 14525934 14697242 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
UBC HMGCR 25348397 N/A physical interaction ComPPI
PTGIR HMGCR 25348397 N/A physical interaction ComPPI
STARD13 HMGCR 14525934 14697242 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
SYVN1 HMGCR 25348397 N/A physical interaction ComPPI
AUP1 HMGCR 25348397 N/A physical interaction ComPPI
RNF139 HMGCR 25348397 N/A physical interaction ComPPI
INSIG1 HMGCR 12535518 14525934 16168377 19458199 20458442 21343306 23223569 24371122 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
AMFR HMGCR 21343306 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KCNS3 HMGCR 25348397 N/A physical interaction ComPPI
FAF2 HMGCR 25348397 N/A physical interaction ComPPI
SPINT2 HMGCR 25348397 N/A physical interaction ComPPI
FAM189A2 HMGCR 25348397 N/A physical interaction ComPPI
SRPRB HMGCR 25348397 N/A physical interaction ComPPI
LPAR1 HMGCR 25348397 N/A physical interaction ComPPI
CD209 HMGCR 25348397 N/A physical interaction ComPPI
HMGCR ERLIN2 21343306 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HMGCR RIC3 25348397 N/A physical interaction ComPPI
HMGCR ATP1B3 25348397 N/A physical interaction ComPPI
HMGCR KCNK16 25348397 N/A physical interaction ComPPI
HMGCR TMEM30A 25348397 N/A physical interaction ComPPI
HMGCR BTN2A1 25348397 N/A physical interaction ComPPI
HMGCR HEPACAM2 25348397 N/A physical interaction ComPPI
HMGCR CHRNA9 25348397 N/A physical interaction ComPPI
HMGCR UNK 25348397 N/A physical interaction ComPPI
HMGCR TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HMGCR UBIAD1 23169578 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
HMGCR GABRA6 25348397 N/A physical interaction ComPPI
HMGCR ADGRG5 25348397 N/A physical interaction ComPPI
HMGCR DNA2 25348397 N/A physical interaction ComPPI
B3GAT3 HMGCR 25348397 N/A physical interaction ComPPI
HMGCR HMGCR 10698924 14525934 N/A experimental interaction detection HPRD
PRKACA HMGCR 2369897 27898060 N/A N/A OmniPath

Visualization










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