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GENE：SLC39A8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SLC39A8
FullNmae solute carrier family 39 member 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20862
EnsembleID ENSG00000138821
Uniprot Q9C0K1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SLC39A8 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SLC39A8 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SLC39A8 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
SLC39A8 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SLC39A8 GO:0005385,GO:0005385,GO:0005765,GO:0005886,GO:0005886,GO:0006351,GO:0006355,GO:0006487,GO:0006525,GO:0006824,GO:0006829,GO:0006882,GO:0015694,GO:0015701,GO:0016323,GO:0016324,GO:0030026,GO:0030198,GO:0031090,GO:0042391,GO:0043124,GO:0050728,GO:0061757,GO:0070574,GO:0071421,GO:0071577,GO:0071577,GO:0071577,GO:0071578,GO:0071578,GO:0097080,GO:0098711,GO:0098849,GO:0140410,GO:0140410,GO:0140412,GO:1990079,GO:1990540

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SLC39A8 hsa:64116 path:hsa04216 Ferroptosis - Homo sapiens (human)
SLC39A8 hsa:64116 path:hsa05010 Alzheimer disease - Homo sapiens (human)
SLC39A8 hsa:64116 path:hsa05012 Parkinson disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SLC39A8 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SLC39A8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SLC39A8 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SLC39A8 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SLC39A8 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SLC39A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SLC39A8 18556457 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 SLC39A8 18556457 trascriptional regulation,stimulation inferred by curator TFlink
MYC SLC39A8 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 SLC39A8 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 SLC39A8 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000019907A SLC39A8 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC SLC39A8 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000239117 SLC39A8 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001BCAC5 SLC39A8 23688035 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
HMOX1 SLC39A8 25348397 N/A physical interaction ComPPI
SLC4A2 SLC39A8 25348397 N/A physical interaction ComPPI
STX4 SLC39A8 25348397 N/A physical interaction ComPPI
ZDHHC17 SLC39A8 25348397 N/A physical interaction ComPPI
VAPB SLC39A8 25348397 N/A physical interaction ComPPI
TAOK2 SLC39A8 25348397 N/A physical interaction ComPPI
EDA SLC39A8 25348397 N/A physical interaction ComPPI
TRIM25 SLC39A8 25348397 N/A physical interaction ComPPI
VANGL2 SLC39A8 25348397 N/A physical interaction ComPPI
GP1BB SLC39A8 25348397 N/A physical interaction ComPPI
PTGER4 SLC39A8 24234451 28298427 physical association ubiquitin reconstruction IntAct

Source Target Pmid Interactiontype Methods Database
URS00003418FB SLC39A8 27087310 direct interaction,inhibition N/A NPInter

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