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GENE：TXNRD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TXNRD1
FullNmae thioredoxin reductase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12437
EnsembleID ENSG00000198431
Uniprot Q16881

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TXNRD1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TXNRD1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TXNRD1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TXNRD1 GO:0001650,GO:0001707,GO:0004791,GO:0004791,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0007165,GO:0008283,GO:0042802,GO:0045454,GO:0050137,GO:0070062,GO:0071949,GO:0098869

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TXNRD1 hsa:7296 path:hsa00450 Selenocompound metabolism - Homo sapiens (human)
TXNRD1 hsa:7296 path:hsa05200 Pathways in cancer - Homo sapiens (human)
TXNRD1 hsa:7296 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TXNRD1 TXN 26192618 interaction type N/A ACSN
NFE2L2 TXNRD1 10441483 10821856 10874044 11279008 11909699 12356737 12511571 15521073 16219762 17512463 18761713 19027064 19747488 23850759 26192618 interaction type N/A ACSN
ISG15 TXNRD1 16009940 23180781 physical association anti tag coimmunoprecipitation,unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
AR TXNRD1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 TXNRD1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 TXNRD1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 TXNRD1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TXNRD1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TXNRD1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 TXNRD1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TXNRD1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C TXNRD1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TXNRD1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 TXNRD1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NFE2L2 TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 TXNRD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 TXNRD1 11375392 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 TXNRD1 N/A rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 TXNRD1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS000021D7C8 TXNRD1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EED18 TXNRD1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 TXNRD1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00005CC20C TXNRD1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 TXNRD1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002AB575 TXNRD1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F TXNRD1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A TXNRD1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F TXNRD1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A TXNRD1 20371350 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000058276F TXNRD1 20371350 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004505E4 TXNRD1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000527B00 TXNRD1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TPD52L2 TXNRD1 25348397 N/A physical interaction ComPPI
ISG15 TXNRD1 25348397 N/A physical interaction ComPPI
PPP1R16A TXNRD1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TUBB TXNRD1 25348397 N/A physical interaction ComPPI
RPIA TXNRD1 25348397 N/A physical interaction ComPPI
TXNDC17 TXNRD1 14525934 14607844 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TXNIP TXNRD1 14525934 25348397 9207062 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
HERC5 TXNRD1 25348397 N/A physical interaction ComPPI
DYNC1LI1 TXNRD1 25348397 N/A physical interaction ComPPI
PDIA6 TXNRD1 25348397 N/A physical interaction ComPPI
NTRK1 TXNRD1 25348397 N/A physical interaction ComPPI
CAV1 TXNRD1 19820694 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,pull down ComPPI,IntAct,OmniPath
HSPA5 TXNRD1 25348397 N/A physical interaction ComPPI
TUBA4A TXNRD1 25348397 N/A physical interaction ComPPI
NAE1 TXNRD1 25348397 N/A physical interaction ComPPI
TNPO1 TXNRD1 25348397 N/A physical interaction ComPPI
RP2 TXNRD1 25348397 N/A physical interaction ComPPI
SEM1 TXNRD1 25348397 N/A physical interaction ComPPI
TRIM25 TXNRD1 25348397 N/A physical interaction ComPPI
ELAVL1 TXNRD1 25348397 N/A physical interaction ComPPI
ESR1 TXNRD1 25348397 N/A physical interaction ComPPI
TXNRD1 GLRX2 14525934 14676218 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
TXNRD1 POU2F1 25348397 N/A physical interaction ComPPI
TXNRD1 POU2F2 25348397 N/A physical interaction ComPPI
TXNRD1 TP53 25348397 N/A physical interaction ComPPI
TXNRD1 APEX1 25348397 N/A physical interaction ComPPI
TXNRD1 SF3B3 25348397 N/A physical interaction ComPPI
TXNRD1 PLS3 25348397 N/A physical interaction ComPPI
TXNRD1 DMRTC2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TXNRD1 IPO5 25348397 N/A physical interaction ComPPI
TXNRD1 TUBA1C 25348397 N/A physical interaction ComPPI
TXNRD1 CRYZ 25348397 N/A physical interaction ComPPI
TXNRD1 OLA1 25348397 N/A physical interaction ComPPI
TXNRD1 PAPSS2 25348397 N/A physical interaction ComPPI
TXNRD1 UBXN1 25348397 N/A physical interaction ComPPI
TXNRD1 SEM1 25348397 N/A physical interaction ComPPI
TXNRD1 NAPRT 25348397 N/A physical interaction ComPPI
TXNRD1 PNPO 25348397 N/A physical interaction ComPPI
TXNRD1 THOP1 25348397 N/A physical interaction ComPPI
TXNRD1 TXNRD2 25348397 N/A physical interaction ComPPI
TXNRD1 CDO1 25348397 N/A physical interaction ComPPI
GABPA TXNRD1 19114066 27898060 stimulant N/A OmniPath
ISG15 TXNRD1 16009940 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B870D TXNRD1 27087310 direct interaction,inhibition N/A NPInter

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