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GENE：ACACA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACACA
FullNmae acetyl-CoA carboxylase alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:84
EnsembleID ENSG00000278540
Uniprot Q13085

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACACA ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACACA ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ACACA GO:0001650,GO:0001894,GO:0003989,GO:0003989,GO:0003989,GO:0003989,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0005829,GO:0005829,GO:0006084,GO:0006633,GO:0006633,GO:0006633,GO:0015629,GO:0019538,GO:0042802,GO:0046872,GO:0046949,GO:0051289,GO:0055088,GO:0071380,GO:2001295

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACACA hsa:31 path:hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
ACACA hsa:31 path:hsa00620 Pyruvate metabolism - Homo sapiens (human)
ACACA hsa:31 path:hsa00640 Propanoate metabolism - Homo sapiens (human)
ACACA hsa:31 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACACA hsa:31 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)
ACACA hsa:31 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
ACACA hsa:31 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
ACACA hsa:31 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
ACACA hsa:31 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ELP1 ACACA 18303054 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACACA SUZ12 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
ACACA RNF2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ACACA 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ACACA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CREB1 ACACA 19842072 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACACA N/A trascriptional regulation,stimulation inferred by curator TFlink
SP3 ACACA N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 ACACA N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 ACACA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ACACA 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 ACACA 18668040 23622248 25416803 mrna cleavage,inhibition experimental interaction detection,clash TarBase
URS00000AA464 ACACA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003FD55 ACACA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D ACACA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 ACACA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E0AEA ACACA 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000015CE89 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000026A1D ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005D35D9 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004ACAAA ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000480E22 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000043B1D ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000B1B47 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000025307A ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000328C0D ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000211070 ACACA 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC379 ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000044FD7 ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000081D1E ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001310DE ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000E732F ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000535FDD ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003883FE ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000037D7E5 ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000021D08 ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001383CF ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000076E54 ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004F507C ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000072B4C8 ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B0B46 ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C ACACA 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA1 ACACA 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKAA2 ACACA 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ACACA PRKAA1 25361965 interaction type N/A PTMCode2
ACACA BRCA1 25361965 interaction type N/A PTMCode2
BRCA1 ACACA 25361965 interaction type N/A PTMCode2
ACACA AKR1B10 25361965 interaction type N/A PTMCode2
AKR1B10 ACACA 25361965 interaction type N/A PTMCode2
ACACA PRKAA2 25361965 interaction type N/A PTMCode2
ACACA ACACB 25361965 interaction type N/A PTMCode2
ACACB ACACA 25361965 interaction type N/A PTMCode2
SIRT1 ACACA 25361965 interaction type N/A PTMCode2
ACACA SIRT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 ACACA 25348397 N/A physical interaction ComPPI
FNDC11 ACACA 25348397 N/A physical interaction ComPPI
CIAO1 ACACA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PRKAA2 ACACA 11052978 14525934 25348397 2900138 N/A experimental interaction detection,physical interaction ComPPI,HPRD
UBASH3B ACACA 25348397 N/A physical interaction ComPPI
NPM1 ACACA 25348397 N/A physical interaction ComPPI
PSMC6 ACACA 25348397 N/A physical interaction ComPPI
KIF5B ACACA 25348397 N/A physical interaction ComPPI
VCP ACACA 25348397 N/A physical interaction ComPPI
ATXN1 ACACA 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
BMI1 ACACA 25348397 N/A physical interaction ComPPI
KEAP1 ACACA 25348397 N/A physical interaction ComPPI
PSMB2 ACACA 25348397 N/A physical interaction ComPPI
NDUFAF4 ACACA 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
EGLN3 ACACA 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
CBL ACACA 25348397 N/A physical interaction ComPPI
SHC1 ACACA 25348397 N/A physical interaction ComPPI
INPPL1 ACACA 25348397 N/A physical interaction ComPPI
PRKAA1 ACACA 11052978 14525934 23455922 24234451 25348397 2900138 7907095 association experimental interaction detection,physical interaction,tandem affinity purification ComPPI,HPRD,IntAct
UBE2N ACACA 25348397 N/A physical interaction ComPPI
NTRK1 ACACA 25348397 N/A physical interaction ComPPI
ENO1 ACACA 25348397 N/A physical interaction ComPPI
PHKG2 ACACA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
COPB1 ACACA 25348397 N/A physical interaction ComPPI
ILK ACACA 17353931 23455922 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CSNK1E ACACA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MYC ACACA 17353931 21150319 24234451 25348397 association,physical association anti bait coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
HNRNPL ACACA 25348397 N/A physical interaction ComPPI
RPS6KA1 ACACA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ARRB1 ACACA 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRK2 ACACA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MDM2 ACACA 25348397 N/A physical interaction ComPPI
EPB41L1 ACACA 25348397 N/A physical interaction ComPPI
EGFR ACACA 25348397 N/A physical interaction ComPPI
RNF2 ACACA 25348397 N/A physical interaction ComPPI
GABARAP ACACA 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PTEN ACACA 25348397 N/A physical interaction ComPPI
STK4 ACACA 23386615 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SIRT1 ACACA 19343720 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PSMD2 ACACA 25348397 N/A physical interaction ComPPI
CA9 ACACA 25348397 N/A physical interaction ComPPI
NFKB1 ACACA 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
IARS1 ACACA 25348397 N/A physical interaction ComPPI
EEF2K ACACA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
AP2M1 ACACA 25348397 N/A physical interaction ComPPI
TRIM25 ACACA 25348397 N/A physical interaction ComPPI
STK3 ACACA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ELP1 ACACA 25348397 N/A physical interaction ComPPI
NUP50 ACACA 25348397 N/A physical interaction ComPPI
SOCS6 ACACA 25348397 N/A physical interaction ComPPI
BRCA1 ACACA 12360400 14525934 16326698 19061860 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
PSMB7 ACACA 25348397 N/A physical interaction ComPPI
PRKAG1 ACACA 25348397 N/A physical interaction ComPPI
PRKAB1 ACACA 25348397 N/A physical interaction ComPPI
MLLT1 ACACA 25348397 N/A physical interaction ComPPI
SUZ12 ACACA 25348397 N/A physical interaction ComPPI
DCAF6 ACACA 25348397 N/A physical interaction ComPPI
FUS ACACA 25348397 N/A physical interaction ComPPI
MCC ACACA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IFIT1 ACACA 21642987 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLLT3 ACACA 25348397 N/A physical interaction ComPPI
LGALS3BP ACACA 25348397 N/A physical interaction ComPPI
STK25 ACACA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CHGB ACACA 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PSG1 ACACA 25348397 N/A physical interaction ComPPI
SIRT7 ACACA 25348397 N/A physical interaction ComPPI
COQ9 ACACA 25348397 N/A physical interaction ComPPI
FBXO6 ACACA 25348397 N/A physical interaction ComPPI
FN1 ACACA 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
CCT3 ACACA 25348397 N/A physical interaction ComPPI
NXF1 ACACA 25348397 N/A physical interaction ComPPI
PPP4R3A ACACA 25348397 N/A physical interaction ComPPI
ERCC6L ACACA 25348397 N/A physical interaction ComPPI
MOV10 ACACA 25348397 N/A physical interaction ComPPI
ACACA AKR1B10 18056116 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,pull down,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
ACACA CSNK1A1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ACACA RIOK2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ACACA ARHGAP25 25348397 N/A physical interaction ComPPI
ACACA LIPH 25348397 N/A physical interaction ComPPI
ACACA NDUFA4 25348397 N/A physical interaction ComPPI
ACACA NMES1 25348397 N/A physical interaction ComPPI
ACACA ZNF746 25348397 N/A physical interaction ComPPI
ACACA OAS2 25348397 N/A physical interaction ComPPI
ACACA ODAPH 25348397 N/A physical interaction ComPPI
ACACA PPP2R2B 25348397 N/A anti tag coimmunoprecipitation ComPPI
ACACA NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CSNK2A1 ACACA 14525934 2900140 N/A experimental interaction detection HPRD
CSNK2A2 ACACA 14525934 2900140 N/A experimental interaction detection HPRD
ACACA ACACA 20457939 24234451 N/A molecular sieving,comigration in non denaturing gel electrophoresis IntAct
MAPT ACACA 24234451 26402096 association anti bait coimmunoprecipitation IntAct
RPL27A ACACA 24234451 30021884 physical association cross-linking study IntAct
PRKAA2 ACACA 11052978 12015362 18212344 18669648 18707149 18767875 19651622 20068231 20166139 27898060 2900138 7907095 inhibition N/A OmniPath
PRKACA ACACA 11052978 15371448 17276402 18303014 19176702 27898060 2900138 2900140 7907095 N/A N/A OmniPath
STK4 ACACA 27898060 2900138 7907095 N/A N/A OmniPath
CSNK2A1 ACACA 18212344 18452278 18669648 18691976 18767875 19413330 19415658 19651622 19664994 19664995 20068231 20166139 27898060 2900140 N/A N/A OmniPath
PRKAA1 ACACA 11052978 14985505 15107497 15371448 15383373 15967841 16407220 16434556 17116771 17137347 17237771 17244528 17255104 17272808 17276402 18195011 18212344 18303014 18431490 18474592 18480843 18482975 18669648 18707149 18715874 18767875 18854318 19061860 19176702 19651622 19958286 20068231 20166139 20489196 21062936 21918180 21931634 22137581 22517326 22561688 23325788 23418352 23455922 23612973 23909401 24247980 24702155 24959379 25065674 25679763 25762623 26143491 26456332 26506235 27898060 2900138 7907095 inhibition N/A OmniPath
CSNK2A2 ACACA 18212344 18452278 18669648 18691976 18767875 19413330 19415658 19651622 19664994 19664995 20068231 20166139 27898060 2900140 N/A N/A OmniPath

Visualization










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