Gene Information gene info

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GENE：CRYAB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CRYAB
FullNmae crystallin alpha B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2389
EnsembleID ENSG00000109846
Uniprot P02511

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CRYAB pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CRYAB ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CRYAB ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CRYAB GO:0001540,GO:0001666,GO:0002088,GO:0005198,GO:0005212,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005739,GO:0005764,GO:0005829,GO:0006457,GO:0006936,GO:0007021,GO:0007517,GO:0008017,GO:0009408,GO:0009986,GO:0010629,GO:0030018,GO:0030308,GO:0030424,GO:0031109,GO:0031333,GO:0031430,GO:0032355,GO:0032387,GO:0032432,GO:0032991,GO:0042026,GO:0042542,GO:0042802,GO:0042803,GO:0043066,GO:0043066,GO:0043067,GO:0043197,GO:0043204,GO:0044877,GO:0045892,GO:0046872,GO:0050821,GO:0051082,GO:0051082,GO:0051403,GO:0060561,GO:0070062,GO:0071480,GO:0097060,GO:0097512,GO:1905907,GO:2000378

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CRYAB hsa:1410 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
CRYAB hsa:1410 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP CRYAB 16049941 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CRYAB 19205872 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 CRYAB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CRYAB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SRF CRYAB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CRYAB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CRYAB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RARA CRYAB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HMGA1 CRYAB 17723105 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A CRYAB 21556774 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2B CRYAB 21556774 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CRYAB 21556774 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
MAPK14 CRYAB 22135298 phosphorylation N/A PhosphoSite
CRYAB HSPB1 25361965 interaction type N/A PTMCode2
HSPB1 CRYAB 25361965 interaction type N/A PTMCode2
CRYAB CRYGC 25361965 interaction type N/A PTMCode2
CRYGC CRYAB 25361965 interaction type N/A PTMCode2
CRYAB APP 25361965 interaction type N/A PTMCode2
APP CRYAB 25361965 interaction type N/A PTMCode2
CRYAB CRYAA 25361965 interaction type N/A PTMCode2
CRYAA CRYAB 25361965 interaction type N/A PTMCode2
CRYAB CASP3 25361965 interaction type N/A PTMCode2
CASP3 CRYAB 25361965 interaction type N/A PTMCode2
CRYBB2 CRYAB 25361965 interaction type N/A PTMCode2
CRYAB CRYBB2 25361965 interaction type N/A PTMCode2
CRYBA1 CRYAB 25361965 interaction type N/A PTMCode2
CRYAB CRYBA1 25361965 interaction type N/A PTMCode2
CRYAB CRYAB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GMCL1 CRYAB 25348397 N/A physical interaction ComPPI
DES CRYAB 25348397 N/A physical interaction ComPPI
BAG3 CRYAB 25348397 N/A physical interaction ComPPI
CRYAA CRYAB 11700327 12601044 14525934 16142923 16760894 17260942 18401461 18639655 19651604 22085609 22153508 22427585 23188086 24234451 25348397 25416956 25694240 25910212 27898060 association,physical association anti bait coimmunoprecipitation,beta lactamase complementation,two hybrid,coimmunoprecipitation,transmission electron microscopy,cosedimentation in solution,dynamic light scattering,experimental interaction detection,mass spectrometry studies of complexes,molecular sieving,nuclear magnetic resonance,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct,OmniPath
CRYAB BCL2L1 14525934 14752512 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CRYAB CS 11377425 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CRYAB CRYBB2 11700327 12601044 14525934 24234451 25348397 association,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CRYAB CRYGC 11700327 12601044 14525934 24234451 25348397 association,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CRYAB PSMA3 11341940 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
CRYAB TTN 25348397 N/A physical interaction,in vitro ComPPI
CRYAB BMPR2 14525934 15188402 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CRYAB HSPB1 11700327 12601044 14525934 1560006 17916631 18330356 20863832 23188086 23532854 24234451 25348397 26186194 27898060 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,nuclear magnetic resonance,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
CRYAB HSPB2 10625651 12601044 23188086 23532854 24234451 25348397 26465331 27898060 physical association two hybrid,nuclear magnetic resonance,physical interaction ComPPI,IntAct,OmniPath
CRYAB CRYAA2 25348397 N/A physical interaction ComPPI
CRYAB HDAC1 25348397 N/A physical interaction ComPPI
CRYAB PSMD4 25348397 N/A physical interaction ComPPI
CRYAB CCND1 25348397 N/A physical interaction ComPPI
CRYAB ADAM2 25348397 N/A physical interaction ComPPI
CRYAB PRKAG3 25348397 N/A physical interaction ComPPI
CRYAB TP53 19343786 19799611 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CRYAB HSPA4 25348397 N/A physical interaction ComPPI
CRYAB APP 14525934 16049941 16053447 17046756 21961594 24234451 25348397 27898060 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct,OmniPath
CRYAB CRYGD 12601044 16274233 21173272 22655036 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CRYAB MDH2 25348397 N/A physical interaction ComPPI
CRYAB BCL2 25348397 N/A physical interaction ComPPI
CRYAB FCGR2A 21357544 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CRYAB CD40LG 25348397 N/A physical interaction ComPPI
CRYAB ALB 25348397 N/A physical interaction ComPPI
CRYAB AVP 16274233 17075130 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CRYAB HSPB8 16225851 24234451 25348397 physical association two hybrid,fluorescent resonance energy transfer,physical interaction ComPPI,IntAct
CRYAB LBH 20587334 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CRYAB SNCA 15236975 20197038 21905118 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CRYAB VEGFA 17487982 21984182 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CRYAB FGF2 25348397 N/A physical interaction ComPPI
CRYAB NGF 25348397 N/A physical interaction ComPPI
CRYAB INS 25348397 N/A physical interaction ComPPI
CRYAB CTNNB1 22158051 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CRYAB CDH16 18343407 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CRYAB GFAP 25348397 N/A physical interaction ComPPI
CRYAB CASP3 18669646 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
CRYAB BAX 25348397 N/A physical interaction ComPPI
CRYAB CRYBA1 17046756 24234451 25348397 N/A circular dichroism,nuclear magnetic resonance,physical interaction ComPPI,IntAct
CRYAB MIP 25348397 N/A physical interaction ComPPI
CRYAB CDH1 22158051 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CRYAB CCL22 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CRYAB SMAD4 25348397 N/A physical interaction ComPPI
CRYAB TRIM33 25348397 N/A physical interaction ComPPI
CRYAB CASP6 25348397 N/A physical interaction ComPPI
CRYAB CASP7 25348397 N/A physical interaction ComPPI
CRYAB CASP8 25348397 N/A physical interaction ComPPI
CRYAB CASP9 25348397 N/A physical interaction ComPPI
CRYAB CASP12 25348397 N/A physical interaction ComPPI
CRYAB XIAP 25348397 N/A physical interaction ComPPI
CRYAB SOD1 25348397 N/A physical interaction ComPPI
CRYAB APOC2 25348397 N/A physical interaction ComPPI
CRYAB B2M 25348397 N/A physical interaction ComPPI
CRYAB HBA1 25348397 N/A physical interaction ComPPI
CRYAB DDX20 25348397 N/A physical interaction ComPPI
CRYAB CRADD 25348397 N/A physical interaction ComPPI
CRYAB PIDD1 25348397 N/A physical interaction ComPPI
CRYAB CASP2 25348397 N/A physical interaction ComPPI
CRYAB ACOT7 25348397 N/A physical interaction ComPPI
CRYAB TNPO2 25348397 N/A physical interaction ComPPI
CRYAB MRPL11 25348397 N/A physical interaction ComPPI
CRYAB NYNRIN 25348397 N/A physical interaction ComPPI
CRYAB SEH1L 25348397 N/A physical interaction ComPPI
CRYAB GEMIN4 25348397 N/A physical interaction ComPPI
CRYAB IQGAP3 25348397 N/A physical interaction ComPPI
CRYAB CDC23 25348397 N/A physical interaction ComPPI
CRYAB HNRNPUL2 25348397 N/A physical interaction ComPPI
CRYAB GOPC 25348397 N/A physical interaction ComPPI
CRYAB NUDT16L1 25348397 N/A physical interaction ComPPI
CRYAB MAP1B 25348397 N/A physical interaction ComPPI
CRYAB NEFL 25348397 N/A physical interaction ComPPI
CRYAB TRAPPC2 25348397 N/A physical interaction ComPPI
CRYAB TRAPPC2B 25348397 N/A physical interaction ComPPI
CRYAB PRELID1 25348397 N/A physical interaction ComPPI
CRYAB SMCR8 25348397 N/A physical interaction ComPPI
CRYAB FBXO21 25348397 N/A physical interaction ComPPI
CRYAB CCDC85C 25348397 N/A physical interaction ComPPI
CRYAB VPS33A 25348397 N/A physical interaction ComPPI
CRYAB LENG8 25348397 N/A physical interaction ComPPI
CRYAB CC2D1A 25348397 N/A physical interaction ComPPI
CRYAB TRAPPC9 25348397 N/A physical interaction ComPPI
CRYAB CCDC85B 25348397 N/A physical interaction ComPPI
CRYAB FAM83D 25348397 N/A physical interaction ComPPI
CRYAB RBM24 25348397 N/A physical interaction ComPPI
CRYAB TMEM109 23542032 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CRYAB SORD 25348397 N/A physical interaction ComPPI
CRYAB FOXD4 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CRYAB SCN5A 25348397 N/A physical interaction ComPPI
CRYAB NEDD4L 25348397 N/A physical interaction ComPPI
CRYAB LYZ 25348397 N/A physical interaction ComPPI
CRYAB GDF5 25348397 N/A physical interaction ComPPI
CRYAB PI4KA 25348397 N/A physical interaction ComPPI
CRYAB MAS1 25348397 N/A physical interaction ComPPI
CRYAB GMCL2 25348397 N/A physical interaction ComPPI
CRYAB OAZ3 25348397 N/A physical interaction ComPPI
CRYAB FCF1 25348397 N/A physical interaction ComPPI
CRYAB TFG 25348397 N/A physical interaction ComPPI
CRYAB GPBP1 25348397 N/A physical interaction ComPPI
CRYAB G3BP1 25348397 N/A physical interaction ComPPI
CRYAB PRKN 25348397 N/A physical interaction ComPPI
CRYAB CRYGS 24183572 24234451 25348397 27898060 N/A dynamic light scattering,nuclear magnetic resonance,physical interaction ComPPI,IntAct,OmniPath
CRYAB CAPN3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
CRYAB KRTAP6-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CRYAB GORASP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CRYAB DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CRYAB ALDOA 24234451 25348397 26465331 physical association two hybrid ComPPI,IntAct
CRYAB DCTN1 24234451 25348397 26465331 physical association two hybrid ComPPI,IntAct
CRYAB LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CRYAB MDC1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
TRAPPC6A CRYAB 25348397 N/A two hybrid,physical interaction ComPPI
KRTAP19-5 CRYAB 25348397 N/A two hybrid,physical interaction ComPPI
KRTAP8-1 CRYAB 25348397 N/A two hybrid,physical interaction ComPPI
UBE2D1 CRYAB 25348397 N/A physical interaction ComPPI
CRYAB CRYAB 11700327 12601044 14525934 18330356 19651604 20802487 21464278 22143763 22153508 23188086 24183572 24234451 26465331 physical association anti bait coimmunoprecipitation,two hybrid,transmission electron microscopy,cosedimentation in solution,cross-linking study,dynamic light scattering,experimental interaction detection,mass spectrometry studies of complexes,molecular sieving,nuclear magnetic resonance,electron tomography,x ray scattering HPRD,IntAct
SRC CRYAB 12060738 27898060 N/A N/A OmniPath
MAF CRYAB 10603348 11069887 27898060 stimulant N/A OmniPath
MAPK14 CRYAB 10706390 11096101 11158243 12060738 12468532 15511225 16129694 16500585 16928191 18061612 19272359 20005263 23049853 24023879 27898060 8175657 9368070 N/A N/A OmniPath
PSIP1 CRYAB 11350077 27898060 stimulant N/A OmniPath

Visualization










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