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GENE：FLNB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FLNB
FullNmae filamin B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3755
EnsembleID ENSG00000136068
Uniprot O75369

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FLNB disulfidptosis 39146597 Previous studies have identified 15 essential genes (FLNA, FLNB, MYH9, TLN1, ACTB, MYL6, MYH10, CAPZB, DSTN, IQGAP1, ACTN4, PDLIM1, CD2AP, INF2, SLC7A11) associated with disulfidptosis. retulator signature

Go Annotation:

GeneSymbol Go id
FLNB GO:0001725,GO:0003334,GO:0003382,GO:0003723,GO:0003779,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005903,GO:0005925,GO:0005938,GO:0007165,GO:0007519,GO:0015629,GO:0016020,GO:0030018,GO:0030036,GO:0042802,GO:0045296,GO:0045335,GO:0051015,GO:0070062,GO:0071346

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FLNB hsa:2317 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
FLNB hsa:2317 path:hsa04510 Focal adhesion - Homo sapiens (human)
FLNB hsa:2317 path:hsa05132 Salmonella infection - Homo sapiens (human)
FLNB hsa:2317 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RAD21 FLNB 22145905 23180781 physical association two hybrid InnateDB
PLCG1 FLNB 17474147 23180781 physical association peptide array InnateDB
ISG15 FLNB 16009940 23180781 physical association unspecified method InnateDB
SUZ12 FLNB 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 FLNB 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
FLNB ARIH1 12582176 16009940 19270716 29145629 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
FLNB ITGB3 20005715 interaction type N/A PSP
FLNB ITGB1 20005715 interaction type N/A PSP
FLNB TSHR 20005715 interaction type N/A PSP
FLNB ITGB6 20005715 interaction type N/A PSP,SignaLink
FLNB PLCG1 20005715 interaction type N/A PSP,SignaLink
FLNB PSEN1 20005715 interaction type N/A PSP
FLNB PSEN2 20005715 interaction type N/A PSP
FLNB SMURF2 20005715 interaction type N/A PSP
FLNB PSEN1 18988627 20005715 21071413 9437013 N/A N/A SignaLink
FLNB SMURF2 15231748 18988627 20005715 N/A N/A SignaLink
FLNB PSEN2 18988627 20005715 20005715 21071413 9437013 9437013 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR FLNB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 FLNB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 FLNB 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 FLNB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C FLNB 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 FLNB 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 FLNB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 FLNB 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001A7F58 FLNB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE FLNB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 FLNB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000006372A FLNB 24374217 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC73 FLNB 25348397 N/A physical interaction ComPPI
ISG15 FLNB 19270716 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NPM1 FLNB 25348397 N/A physical interaction ComPPI
VCP FLNB 25348397 N/A physical interaction ComPPI
MCM5 FLNB 25348397 N/A physical interaction ComPPI
PPP1CB FLNB 25348397 N/A physical interaction ComPPI
RAD21 FLNB 25348397 N/A physical interaction ComPPI
KEAP1 FLNB 25348397 N/A physical interaction ComPPI
MCM2 FLNB 25348397 N/A physical interaction ComPPI
MAP1LC3B FLNB 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RAC1 FLNB 19270716 24234451 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
CRK FLNB 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
VBP1 FLNB 25348397 N/A physical interaction ComPPI
SMURF2 FLNB 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MAPK8 FLNB 19270716 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
PIK3R1 FLNB 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NCK1 FLNB 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 FLNB 12577067 17474147 24234451 25348397 association,physical association peptide array,pull down ComPPI,IntAct
FLNC FLNB 25348397 N/A physical interaction ComPPI
ITGB1 FLNB 25348397 N/A two hybrid,physical interaction,in vitro ComPPI
FLNA FLNB 12393796 14525934 22939629 24234451 25348397 26344197 26496610 27898060 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
ARFIP1 FLNB 25348397 N/A physical interaction ComPPI
CDH1 FLNB 25348397 N/A physical interaction ComPPI
ITGB3 FLNB 25348397 N/A physical interaction ComPPI
ITGB3BP FLNB 25348397 N/A physical interaction ComPPI
MAP2K4 FLNB 25348397 N/A physical interaction ComPPI
FMNL1 FLNB 25348397 N/A physical interaction ComPPI
MAP3K4 FLNB 19270716 24234451 25348397 association,physical association pull down ComPPI,IntAct
RALA FLNB 25348397 N/A physical interaction ComPPI
CD247 FLNB 24234451 24502978 25348397 association pull down ComPPI,IntAct
HNRNPL FLNB 25348397 N/A physical interaction ComPPI
EIF4EBP1 FLNB 25348397 N/A physical interaction ComPPI
IQGAP1 FLNB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFTR FLNB 25348397 N/A physical interaction ComPPI
NPHP1 FLNB 12006559 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SQSTM1 FLNB 25348397 N/A physical interaction ComPPI
AHNAK FLNB 25348397 N/A physical interaction ComPPI
MYO18A FLNB 25348397 N/A physical interaction ComPPI
ABCE1 FLNB 25348397 N/A physical interaction ComPPI
ASB2 FLNB 25348397 N/A physical interaction ComPPI
ARRB2 FLNB 25348397 N/A physical interaction ComPPI
PSEN2 FLNB 14525934 24234451 25348397 9437013 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
AP1B1 FLNB 25348397 N/A physical interaction ComPPI
AP1G1 FLNB 25348397 N/A physical interaction ComPPI
CDK2 FLNB 25348397 N/A physical interaction ComPPI
TUBA1A FLNB 24234451 25348397 27291054 association pull down ComPPI,IntAct
RNF2 FLNB 25348397 N/A physical interaction ComPPI
HSPB1 FLNB 24234451 25277244 25348397 physical association reverse ras recruitment system,physical interaction ComPPI,IntAct
PTEN FLNB 25348397 N/A physical interaction ComPPI
MDC1 FLNB 25348397 N/A physical interaction ComPPI
GGA1 FLNB 25348397 N/A physical interaction ComPPI
VCAM1 FLNB 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 FLNB 25348397 N/A physical interaction ComPPI
FLNB TSHR 14525934 25348397 27898060 8327473 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
FLNB FBLIM1 12496242 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
FLNB PSEN1 14525934 24234451 25348397 9437013 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
FLNB ITGB6 25348397 N/A physical interaction ComPPI
FLNB GP1BA 25348397 27898060 9651345 N/A physical interaction ComPPI,OmniPath
FLNB OTUD1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNB G3BP1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNB PLEKHO1 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FLNB SIRT7 25348397 N/A physical interaction ComPPI
FLNB MAP3K1 19270716 24234451 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
FLNB HNRNPA0 25348397 N/A physical interaction ComPPI
FLNB ZC3H4 25348397 N/A physical interaction ComPPI
FLNB NUP210 25348397 N/A physical interaction ComPPI
FLNB HNRNPM 25348397 N/A physical interaction ComPPI
FLNB CSTB 25348397 N/A physical interaction ComPPI
FLNB ESR1 21182205 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
FLNB FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
FLNB MLH1 20706999 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FLNB DCTN2 25348397 N/A physical interaction ComPPI
FLNB DCTN3 25348397 N/A physical interaction ComPPI
FLNB TXNL1 25348397 N/A physical interaction ComPPI
FLNB UBR4 25348397 N/A physical interaction ComPPI
FLNB MAD1L1 25348397 N/A physical interaction ComPPI
FLNB PSMD12 25348397 N/A physical interaction ComPPI
FLNB PSMD3 25348397 N/A physical interaction ComPPI
FLNB TRIM55 25348397 N/A physical interaction ComPPI
FLNB CUL7 25348397 N/A physical interaction ComPPI
FLNB OBSL1 25348397 N/A physical interaction ComPPI
FLNB CCDC8 25348397 N/A physical interaction ComPPI
FLNB SUZ12 25348397 N/A physical interaction ComPPI
FLNB SIRT6 25348397 N/A physical interaction ComPPI
FLNB BASP1 25348397 N/A physical interaction ComPPI
FLNB DCPS 25348397 N/A physical interaction ComPPI
FLNB MAP4 25348397 N/A physical interaction ComPPI
FLNB NUP50 25348397 N/A physical interaction ComPPI
FLNB SEPTIN6 25348397 N/A physical interaction ComPPI
FLNB TARDBP 25348397 N/A physical interaction ComPPI
FLNB NMD3 25348397 N/A physical interaction ComPPI
FLNB RSU1 25348397 N/A physical interaction ComPPI
FLNB SEC13 25348397 N/A physical interaction ComPPI
FLNB MEAK7 25348397 N/A physical interaction ComPPI
FLNB UFD1 25348397 N/A physical interaction ComPPI
FLNB MED4 25348397 N/A physical interaction ComPPI
FLNB CAPZA2 25348397 N/A physical interaction ComPPI
FLNB DBN1 25348397 N/A physical interaction ComPPI
FLNB MYH9 25348397 N/A physical interaction ComPPI
FLNB SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNB LIMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLNB ANLN 25348397 N/A physical interaction ComPPI
FLNB MYO19 25348397 N/A physical interaction ComPPI
FLNB TSC22D2 25348397 N/A physical interaction ComPPI
FLNB HSPB7 25348397 N/A physical interaction ComPPI
FLNB TRIM25 25348397 N/A physical interaction ComPPI
FLNB BRCA1 25348397 N/A physical interaction ComPPI
FLNB TES 25348397 N/A physical interaction ComPPI
FLNB ATF7IP 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
FLNB PLCG1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
FLNB UBE2L6 19270716 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
FLNB ESR2 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
FLNB GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FLNB MYBPC2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
FLNB TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
FLNB BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
FLNB KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
SEPTIN9 FLNB 25348397 N/A physical interaction ComPPI
LEO1 FLNB 25348397 N/A physical interaction ComPPI
FLNB FLNB 11807098 12006559 12393796 14525934 24234451 physical association two hybrid,experimental interaction detection,two hybrid HPRD,IntAct
L1TD1 FLNB 24234451 25702638 association anti bait coimmunoprecipitation IntAct
PLCG1 FLNB 17474147 27898060 N/A N/A OmniPath
RAD21 FLNB 22145905 27898060 N/A N/A OmniPath
SUZ12 FLNB 24457600 27898060 N/A N/A OmniPath
RNF2 FLNB 24457600 27898060 N/A N/A OmniPath
FLNB ISG15 16009940 19270716 27898060 N/A N/A OmniPath

Visualization










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