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GENE：TLN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TLN1
FullNmae talin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11845
EnsembleID ENSG00000137076
Uniprot Q9Y490

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TLN1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TLN1 disulfidptosis 39146597 Previous studies have identified 15 essential genes (FLNA, FLNB, MYH9, TLN1, ACTB, MYL6, MYH10, CAPZB, DSTN, IQGAP1, ACTN4, PDLIM1, CD2AP, INF2, SLC7A11) associated with disulfidptosis. retulator signature

Go Annotation:

GeneSymbol Go id
TLN1 GO:0001726,GO:0001786,GO:0005178,GO:0005178,GO:0005200,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0005925,GO:0005925,GO:0005925,GO:0005925,GO:0007043,GO:0007044,GO:0007229,GO:0009986,GO:0017166,GO:0030274,GO:0030866,GO:0032587,GO:0033622,GO:0035091,GO:0045296,GO:0051015,GO:0051893,GO:0070062,GO:0070527,GO:0098609

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TLN1 hsa:7094 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
TLN1 hsa:7094 path:hsa04510 Focal adhesion - Homo sapiens (human)
TLN1 hsa:7094 path:hsa04611 Platelet activation - Homo sapiens (human)
TLN1 hsa:7094 path:hsa05131 Shigellosis - Homo sapiens (human)
TLN1 hsa:7094 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ICAM1 TLN1 10591186 11592085 12413632 12616499 14662834 15356110 1673988 19454690 19965656 20231889 2150484 23364881 23886063 24343663 24440149 25384214 26192618 7512027 9712030 9738502 interaction type N/A ACSN
TLN1 TUBGCP2 10591186 11592085 12413632 12616499 14662834 15356110 1673988 19454690 19965656 20231889 2150484 23364881 23886063 24343663 24440149 25384214 26192618 7512027 9712030 9738502 interaction type N/A ACSN
TLN1 TUBGCP3 10591186 11592085 12413632 12616499 14662834 15356110 1673988 19454690 19965656 20231889 2150484 23364881 23886063 24343663 24440149 25384214 26192618 7512027 9712030 9738502 interaction type N/A ACSN
TLN1 TUBGCP4 10591186 11592085 12413632 12616499 14662834 15356110 1673988 19454690 19965656 20231889 2150484 23364881 23886063 24343663 24440149 25384214 26192618 7512027 9712030 9738502 interaction type N/A ACSN
TLN1 TUBGCP5 10591186 11592085 12413632 12616499 14662834 15356110 1673988 19454690 19965656 20231889 2150484 23364881 23886063 24343663 24440149 25384214 26192618 7512027 9712030 9738502 interaction type N/A ACSN
TLN1 TUBGCP6 10591186 11592085 12413632 12616499 14662834 15356110 1673988 19454690 19965656 20231889 2150484 23364881 23886063 24343663 24440149 25384214 26192618 7512027 9712030 9738502 interaction type N/A ACSN
TLN1 PXN 10591186 11592085 12413632 12616499 14662834 15356110 1673988 19454690 19965656 20231889 2150484 23364881 23886063 24343663 24440149 25384214 26192618 7512027 9712030 9738502 interaction type N/A ACSN
VAV1 TLN1 10077632 10646608 10679059 10714681 10849438 10898494 11080163 11526404 11698448 11754814 11994416 12094222 12165654 12186560 12616499 12626562 12740575 12885870 12917349 14764585 15169881 16887996 19909365 20189481 22513334 22786724 22952938 25355530 25539813 26192618 26552706 8189062 8226994 9438848 interaction type N/A ACSN
CD226 TLN1 10591186 12913096 14676297 19029380 22285893 24337740 24658051 26192618 26552706 26840537 28893624 8673704 interaction type N/A ACSN
CD44 TLN1 22566907 23620508 23886063 26192618 interaction type N/A ACSN
CRTAM TLN1 15811952 22285893 26192618 26694968 interaction type N/A ACSN
SCRIB TLN1 15811952 22285893 26192618 26694968 interaction type N/A ACSN
TLN1 PRDM1 20421211 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
ITGB5 TLN1 22025551 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TLN1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 TLN1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 TLN1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TLN1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TLN1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 TLN1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000512C88 TLN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 TLN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE TLN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 TLN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 TLN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 TLN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 TLN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000072E4C TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD TLN1 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C1E1 TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000033B91D TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005A8A8D TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B TLN1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 TLN1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 TLN1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000009EA8F TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000BB229 TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004E02F2 TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005F9738 TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000215483 TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000BD6DC TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000004BACE TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000015A0D9 TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000ECE9C TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000001A7A TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002E728C TLN1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK5 TLN1 22135298 phosphorylation N/A PhosphoSite
ITGB2 TLN1 25361965 interaction type N/A PTMCode2
TLN1 ITGB2 25361965 interaction type N/A PTMCode2
ITGB3 TLN1 25361965 interaction type N/A PTMCode2
TLN1 ITGB3 25361965 interaction type N/A PTMCode2
ITGA2B TLN1 25361965 interaction type N/A PTMCode2
TLN1 ITGA2B 25361965 interaction type N/A PTMCode2
ITGA1 TLN1 25361965 interaction type N/A PTMCode2
TLN1 ITGA1 25361965 interaction type N/A PTMCode2
TLN1 ITGB1 25361965 interaction type N/A PTMCode2
ITGB1 TLN1 25361965 interaction type N/A PTMCode2
ITGB7 TLN1 25361965 interaction type N/A PTMCode2
TLN1 ITGB7 25361965 interaction type N/A PTMCode2
ITGB5 TLN1 25361965 interaction type N/A PTMCode2
TLN1 ITGB5 25361965 interaction type N/A PTMCode2
VCL TLN1 25361965 interaction type N/A PTMCode2
TLN1 VCL 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 TLN1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GPKOW TLN1 25348397 N/A physical interaction ComPPI
CDC5L TLN1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA8 TLN1 24234451 25348397 29568061 association pull down ComPPI,IntAct
TXNDC12 TLN1 25348397 N/A physical interaction ComPPI
SGTB TLN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGB5 TLN1 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MCM2 TLN1 25348397 N/A physical interaction ComPPI
ERBB2 TLN1 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PTK2B TLN1 14525934 25348397 9442086 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BLNK TLN1 25348397 N/A physical interaction ComPPI
SRC TLN1 25348397 N/A physical interaction ComPPI
DOK1 TLN1 25348397 N/A physical interaction ComPPI
ITGB1 TLN1 11279249 24234451 25348397 physical association physical interaction,in vivo,solid phase assay ComPPI,IntAct
U2AF2 TLN1 25348397 N/A physical interaction ComPPI
RBM4 TLN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ TLN1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
NTRK1 TLN1 25348397 N/A physical interaction ComPPI
FAF1 TLN1 25348397 N/A physical interaction ComPPI
CDH1 TLN1 25348397 N/A physical interaction ComPPI
PKD1 TLN1 11113628 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGB3 TLN1 10497223 11932255 12606711 14525934 16546176 24234451 25348397 N/A experimental interaction detection,physical interaction,affinity technology,enzyme linked immunosorbent assay,saturation binding,in vitro,in vivo ComPPI,HPRD,IntAct
BAG6 TLN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLN1 ITGA1 11336656 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TLN1 PXN 25348397 N/A physical interaction,in vivo ComPPI
TLN1 NRAP 10320340 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TLN1 VCL 14525934 15070891 15988023 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
TLN1 ACTA1 10581178 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TLN1 TES 12571287 12695497 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TLN1 ITGA2B 14525934 16546176 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TLN1 ITGB7 12606711 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TLN1 PTK2 25348397 N/A physical interaction ComPPI
TLN1 TERF2 25348397 N/A physical interaction ComPPI
TLN1 CDK5 25348397 N/A physical interaction ComPPI
TLN1 SMURF1 25348397 N/A physical interaction ComPPI
TLN1 DAG1 25348397 N/A physical interaction ComPPI
TLN1 TUBA1A 25348397 N/A physical interaction ComPPI
TLN1 SIRT7 25348397 N/A physical interaction ComPPI
TLN1 CDK2 25348397 N/A physical interaction ComPPI
TLN1 UBA1 25348397 N/A physical interaction ComPPI
TLN1 TRIP6 25348397 N/A physical interaction ComPPI
TLN1 IARS1 25348397 N/A physical interaction ComPPI
TLN1 NAB2 25348397 N/A physical interaction ComPPI
TLN1 DARS1 25348397 N/A physical interaction ComPPI
TLN1 USP19 25348397 N/A physical interaction ComPPI
TLN1 TXLNG 25348397 N/A physical interaction ComPPI
TLN1 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
TLN1 VCAM1 19738201 22623428 24234451 25348397 association cross-linking study,pull down,physical interaction ComPPI,IntAct
TLN1 EGFR 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
TLN1 ITGA4 25348397 N/A physical interaction ComPPI
TLN1 PIP5K1C 25348397 N/A physical interaction ComPPI
TLN1 FAM114A1 25348397 N/A physical interaction ComPPI
TLN1 CC2D1B 25348397 N/A physical interaction ComPPI
TLN1 NUDC 25348397 N/A physical interaction ComPPI
TLN1 PRDX4 25348397 N/A physical interaction ComPPI
TLN1 ASB9 25348397 N/A physical interaction ComPPI
TLN1 SHMT2 25348397 N/A physical interaction ComPPI
TLN1 MOV10 25348397 N/A physical interaction ComPPI
TLN1 NXF1 25348397 N/A physical interaction ComPPI
TLN1 CUL7 25348397 N/A physical interaction ComPPI
TLN1 OBSL1 25348397 N/A physical interaction ComPPI
TLN1 CYP1A1 25348397 N/A physical interaction ComPPI
TLN1 RGCC 25348397 N/A physical interaction ComPPI
TLN1 NMD3 25348397 N/A physical interaction ComPPI
TLN1 RNASEH2C 25348397 N/A physical interaction ComPPI
TLN1 TTC37 25348397 N/A physical interaction ComPPI
TLN1 WAC 25348397 N/A physical interaction ComPPI
TLN1 MED4 25348397 N/A physical interaction ComPPI
TLN1 HNRNPD 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLN1 KIF11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLN1 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLN1 SYNCRIP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLN1 MRPL50 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLN1 SAMD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLN1 KANK4 25348397 N/A physical interaction ComPPI
TLN1 GTF2E2 25348397 N/A physical interaction ComPPI
TLN1 FGB 25348397 N/A physical interaction ComPPI
TLN1 MTNR1A 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
TLN1 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
TLN1 DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TLN1 BRCA1 25348397 N/A physical interaction ComPPI
TLN1 ITGA5 25348397 N/A physical interaction ComPPI
TLN1 ABI1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
TLN1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
ITGB2 TLN1 25348397 N/A in vitro,in vivo ComPPI
YWHAQ TLN1 25348397 N/A physical interaction ComPPI
SNRNP27 TLN1 25348397 N/A physical interaction ComPPI
BLVRA TLN1 25348397 N/A physical interaction ComPPI
LRP2 TLN1 10827173 14525934 N/A two hybrid HPRD
NUMA1 TLN1 24234451 30021884 physical association cross-linking study IntAct
H2BC21 TLN1 24234451 30021884 physical association cross-linking study IntAct
H2BC5 TLN1 24234451 30021884 physical association cross-linking study IntAct
CDK5 TLN1 19363486 24793790 26091349 27898060 stimulant N/A OmniPath
TLN1 ITGB1 11279249 12606711 19118212 22939629 27898060 3124107 7716514 stimulant N/A OmniPath
DAPK1 TLN1 16476779 27898060 inhibition N/A OmniPath

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