Gene Information gene info

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GENE：MYL6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MYL6
FullNmae myosin light chain 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7587
EnsembleID ENSG00000092841
Uniprot P60660

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MYL6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MYL6 disulfidptosis 39146597 Previous studies have identified 15 essential genes (FLNA, FLNB, MYH9, TLN1, ACTB, MYL6, MYH10, CAPZB, DSTN, IQGAP1, ACTN4, PDLIM1, CD2AP, INF2, SLC7A11) associated with disulfidptosis. retulator signature

Go Annotation:

GeneSymbol Go id
MYL6 GO:0000146,GO:0003774,GO:0005509,GO:0005515,GO:0005829,GO:0005903,GO:0006936,GO:0007519,GO:0008307,GO:0008307,GO:0016020,GO:0016459,GO:0016460,GO:0016461,GO:0030049,GO:0031982,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MYL6 hsa:4637 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
MYL6 hsa:4637 path:hsa04530 Tight junction - Homo sapiens (human)
MYL6 hsa:4637 path:hsa04814 Motor proteins - Homo sapiens (human)
MYL6 hsa:4637 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NDUFAF1 MYL6 17344420 23180781 physical association tandem affinity purification InnateDB
IL7R MYL6 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB
MYL6 TSGA10 20797700 23180781 physical association affinity chromatography technology InnateDB
SUZ12 MYL6 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 MYL6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MYL6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MYL6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA MYL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR MYL6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F2EB0 MYL6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 MYL6 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
NUDT21 MYL6 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach ComPPI,IntAct
LGALS3 MYL6 25348397 N/A physical interaction ComPPI
DES MYL6 25348397 N/A physical interaction ComPPI
EIF1B MYL6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATP5F1B MYL6 25348397 N/A physical interaction ComPPI
GLP1R MYL6 25348397 N/A physical interaction ComPPI
ACTB MYL6 15047060 24234451 25348397 physical association molecular sieving ComPPI,IntAct
PPP1CB MYL6 15545284 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CALM1 MYL6 25348397 N/A physical interaction,inference by socio-affinity scoring ComPPI
IQGAP3 MYL6 25348397 N/A physical interaction ComPPI
KEAP1 MYL6 25348397 N/A physical interaction ComPPI
MCM2 MYL6 25348397 N/A physical interaction ComPPI
MYL6B MYL6 25348397 N/A physical interaction ComPPI
RAC1 MYL6 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
HSP90AB1 MYL6 25348397 N/A physical interaction ComPPI
PPP1R9A MYL6 25348397 N/A physical interaction ComPPI
GRB2 MYL6 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN MYL6 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
TPM2 MYL6 25348397 N/A physical interaction ComPPI
TNFRSF1A MYL6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
IQGAP1 MYL6 25348397 N/A physical interaction ComPPI
CFTR MYL6 25348397 N/A physical interaction ComPPI
PDLIM7 MYL6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF6 MYL6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EWSR1 MYL6 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
AHNAK MYL6 25348397 N/A physical interaction ComPPI
MYO18A MYL6 25348397 N/A physical interaction ComPPI
RAB2A MYL6 25348397 N/A physical interaction ComPPI
RANBP1 MYL6 25348397 N/A physical interaction ComPPI
CBX4 MYL6 25348397 N/A physical interaction ComPPI
ARRB1 MYL6 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARRB2 MYL6 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 MYL6 25348397 N/A physical interaction ComPPI
CUL1 MYL6 25348397 N/A physical interaction ComPPI
VHL MYL6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PINX1 MYL6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
OCRL MYL6 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HDAC6 MYL6 25348397 N/A physical interaction ComPPI
CHUK MYL6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK3 MYL6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
VCAM1 MYL6 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 MYL6 25348397 N/A physical interaction ComPPI
GRIPAP1 MYL6 25348397 N/A physical interaction ComPPI
BECN1 MYL6 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TRIM25 MYL6 25348397 N/A physical interaction ComPPI
ESR1 MYL6 21182205 21217774 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,phage display,physical interaction ComPPI,IntAct
ESR2 MYL6 21182203 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient ComPPI,IntAct
STMN1 MYL6 25348397 N/A physical interaction ComPPI
MLH1 MYL6 20706999 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP3K3 MYL6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MOB4 MYL6 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ANLN MYL6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRRM2 MYL6 25348397 N/A physical interaction ComPPI
RCN1 MYL6 25348397 N/A physical interaction ComPPI
IKBKE MYL6 14743216 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
PAN2 MYL6 25348397 N/A physical interaction ComPPI
ATF2 MYL6 22304920 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TES MYL6 25348397 N/A physical interaction ComPPI
SUZ12 MYL6 25348397 N/A physical interaction ComPPI
MYL12B MYL6 25348397 N/A physical interaction ComPPI
MYH9 MYL6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSD17B10 MYL6 25348397 N/A physical interaction ComPPI
MYL6 DNAJB9 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MYL6 USP18 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYL6 USP46 25348397 N/A physical interaction ComPPI
MYL6 USP45 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYL6 LRRK2 24234451 24725412 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MYL6 TSGA10 25348397 N/A physical interaction ComPPI
MYL6 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
MYL6 MYH14 25348397 N/A physical interaction ComPPI
MYL6 MYL12A 25348397 N/A physical interaction ComPPI
MYL6 ADAMTS12 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MYL6 AHCYL1 25348397 N/A physical interaction ComPPI
MYL6 CYC1 25348397 N/A physical interaction ComPPI
MYL6 PHGDH 25348397 N/A physical interaction ComPPI
MYL6 MYH11 25348397 N/A physical interaction ComPPI
MYL6 MYO19 25348397 N/A physical interaction ComPPI
MYL6 BOD1L1 25348397 N/A physical interaction ComPPI
MYL6 FAM210A 25348397 N/A physical interaction ComPPI
MYL6 LIMA1 25348397 N/A physical interaction ComPPI
MYL6 MYH10 25348397 N/A physical interaction ComPPI
MYL6 DCAF4L2 25348397 N/A physical interaction ComPPI
MYL6 IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MYL6 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MYL6 PPP2R2B 19156129 24234451 25348397 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
MYL6 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MYL6 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MYL6 CALM2 24234451 physical association inference by socio-affinity scoring IntAct
METTL14 MYL6 24234451 29507755 association anti tag coimmunoprecipitation IntAct
L1TD1 MYL6 24234451 25702638 association anti bait coimmunoprecipitation IntAct
TPT1 MYL6 24234451 27607350 association anti bait coimmunoprecipitation IntAct
IL7R MYL6 20167604 27898060 N/A N/A OmniPath

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