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GENE：COX19

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COX19
FullNmae cytochrome c oxidase assembly factor COX19
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28074
EnsembleID ENSG00000240230
Uniprot Q49B96

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COX19 cuproptosis 38904833 We used the three key mRNAs COX19, MAP2K2, and FDX1 as a classification model that may systematically elucidate the complex connection between cuproptosis and the immune microenvironment of osteoporosis. retulator signature
COX19 cuproptosis 37979442 Cu chaperones deliver Cu to COX, including COX11, COX17, COX19, COX23, SCO1(synthesis of cytochrome C oxidase 1), and SCO2. Cu chaperones
COX19 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
COX19 cuproptosis 35964468 By LASSO and COX regressions, 16 prognosis-related cuproptosis genes were further selected and their HR was obtained. cuproptosis-related genes
COX19 cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.44 database.
COX19 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway

Go Annotation:

GeneSymbol Go id
COX19 GO:0005515,GO:0005739,GO:0005758,GO:0005758,GO:0005829,GO:0006878,GO:0033617

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COX19 hsa:90639 path:hsa04714 Thermogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 COX19 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 COX19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA COX19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COX19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 COX19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS COX19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COX19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF COX19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 COX19 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR COX19 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000075C1E1 COX19 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F COX19 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 COX19 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000035AC91 COX19 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005BB0FD COX19 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A COX19 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 COX19 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 COX19 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004CFC54 COX19 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B COX19 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 COX19 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B COX19 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 COX19 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE COX19 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 COX19 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA COX19 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A COX19 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 COX19 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000020579D COX19 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 COX19 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 COX19 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000023F008 COX19 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AIFM1 COX19 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SFXN1 COX19 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX6B1 COX19 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SCO1 COX19 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

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