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GENE：SCO1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SCO1
FullNmae synthesis of cytochrome C oxidase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10603
EnsembleID ENSG00000133028
Uniprot O75880

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SCO1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SCO1 cuproptosis 36276096 This study aimed to evaluate the pan-cancer genomics and clinical association of cuproptosis and copper metabolism-related cell death genes, including SLC25A3, SLC25A37, SLC31A1, FDX1, DLAT, LIAS, ATP7A, ATP7B, COX17, SCO1, SCO2, COX11, and COX19. retulator signature
SCO1 cuproptosis 36882769 Copper ions entering the cytoplasm and mitochondrial intermembrane space bind to GSH and MT or form copper-containing molecular chaperones such as SOD1 which is crucial for proper function of copper. To sustain normal cellular functions, COA6, SCO1 and SCO2 work together to mediate the transfer of copper to COX in the mitochondrial intermembrane space. copper transport
SCO1 cuproptosis 36882769 Cytochrome c oxidase copper chaperone(COX17) carried copper ions from the cytoplasm into the intermembrane space of mitochondria, and further delivered copper ions to the cysteine residues of SCO1 with which it formed disulfide bonds. Driver
SCO1 cuproptosis 36882769 Cytochrome c oxidase assembly factor 6(COA6) served as a thiol-disulfide oxidoreductase to reduce the formation of disulfide bonds between cysteine residues in synthesis of cytochrome c oxidase1/2 (SCO1/2) and substances other than copper, thus allowing copper binding. The deficiency of COA6 lead to disorder of respiratory complex IV biogenesis. Driver
SCO1 cuproptosis 36882769 Moreover, SCO1 and SCO2 were also involved in the regulation of cellular copper homeostasis, and the absence of both decreases cellular copper ion levels.. Driver
SCO1 cuproptosis 37979442 Cu chaperones deliver Cu to COX, including COX11, COX17, COX19, COX23, SCO1(synthesis of cytochrome C oxidase 1), and SCO2. Cu chaperones
SCO1 cuproptosis 38339398 Synthesis of Cytochrome C Oxidase 1 (SCO1 and SCO2):Delivers copper to COX2 and helps maintain copper homeostasis copper ionophores
SCO1 cuproptosis 38348451 Involved in the assembly of cytochrome c oxidase. Perturbations in mitochondrial function may contribute to cuproptosis. CRGs in the cuproptosis pathway
SCO1 cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.43 database.
SCO1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway
SCO1 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
SCO1 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
SCO1 cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
SCO1 GO:0005507,GO:0005515,GO:0005739,GO:0005743,GO:0006878,GO:0016531,GO:0030016,GO:0033617,GO:0033617

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SCO1 MT-CO2 15229189 18458339 19393246 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR SCO1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SCO1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SCO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SCO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SCO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 SCO1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AD002 SCO1 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 SCO1 23446348 23592263 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA SCO1 23592263 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000002569A SCO1 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 SCO1 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00004977C5 SCO1 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 SCO1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 SCO1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF SCO1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 SCO1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004214BB SCO1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED SCO1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047E28E SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AAAFF SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 SCO1 23706177 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000411752 SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000038446A SCO1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D SCO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C SCO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC SCO1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D SCO1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C85B2 SCO1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002152A8 SCO1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AB32B SCO1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027352D SCO1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003D4175 SCO1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075A760 SCO1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SCO1 COX17 25361965 interaction type N/A PTMCode2
COX17 SCO1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CHCHD3 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FHL3 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATP5PO SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX5B SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CDCA3 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SNAP29 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TOMM22 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX5A SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TIMMDC1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFAF4 SCO1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
COX17 SCO1 18458339 24234451 25348397 29568061 association mass spectrometry studies of complexes,nuclear magnetic resonance,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SAMM50 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TTN SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NIT1 SCO1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HAX1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AKAP1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AKAP12 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPB SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SYNCRIP SCO1 25348397 N/A physical interaction ComPPI
UQCRC2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UQCRC1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LRPPRC SCO1 25348397 N/A physical interaction ComPPI
TTC19 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TIMM8A SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TIMM13 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
IMMT SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GFER SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPX SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPP SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TOMM20 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS7 SCO1 24234451 24344204 25348397 29568061 association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CIDEB SCO1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIRC6 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PPEF1 SCO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
EYA2 SCO1 25348397 N/A physical interaction ComPPI
MTX2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MED4 SCO1 25348397 N/A physical interaction ComPPI
NUP93 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AK2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MTMR12 SCO1 25348397 N/A physical interaction ComPPI
ATP5F1C SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ECH1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFA5 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PTCD3 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MAVS SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPS22 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS6 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PLGRKT SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPS31 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AFG3L2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFA7 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
KIAA1191 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRIAP1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SEC16A SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GLS SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ETFA SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ETFB SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PYCR2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TOMM70 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
YME1L1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MICU2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UBR4 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATAD3B SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ACOT2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TIMM8B SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SLC25A12 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPS14 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATP5PB SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SFXN1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX6B1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RIPK4 SCO1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
NDUFS2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SLC25A13 SCO1 23260140 24234451 25348397 29568061 association blue native page,proximity-dependent biotin identification ComPPI,IntAct
COX15 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATP5PF SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPS23 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ENDOG SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFS3 SCO1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
OCIAD1 SCO1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CHCHD6 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFA8 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LETM1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
OPA1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CHCHD4 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LACTB SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DNAJC11 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COA7 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PYCR1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CMC2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX14 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COA6 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SMIM12 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HCCS SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
C1ORF198 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MIX23 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CPOX SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
IARS2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SYAP1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SCO2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NDUFA4 SCO1 25348397 N/A physical interaction ComPPI
TMEM126B SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
OPA3 SCO1 25348397 N/A physical interaction ComPPI
OXCT1 SCO1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMM10 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TIMM9 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ACOT1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPS36 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CCDC51 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX11 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FAM136A SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
APOOL SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CRYBG3 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
WDR19 SCO1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
COX16 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EYA4 SCO1 25348397 N/A physical interaction ComPPI
MTX3 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SCO1 CISD3 25348397 N/A physical interaction ComPPI
SCO1 COX19 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SCO1 CMC4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
STK38L SCO1 24234451 30108113 association pull down IntAct
SCO1 PTGS2 11086158 11546815 27898060 N/A N/A OmniPath

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