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GENE：SCO2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SCO2
FullNmae synthesis of cytochrome C oxidase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10604
EnsembleID ENSG00000284194
Uniprot O43819

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SCO2 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SCO2 cuproptosis 36276096 This study aimed to evaluate the pan-cancer genomics and clinical association of cuproptosis and copper metabolism-related cell death genes, including SLC25A3, SLC25A37, SLC31A1, FDX1, DLAT, LIAS, ATP7A, ATP7B, COX17, SCO1, SCO2, COX11, and COX19. retulator signature
SCO2 cuproptosis 36882769 Copper ions entering the cytoplasm and mitochondrial intermembrane space bind to GSH and MT or form copper-containing molecular chaperones such as SOD1 which is crucial for proper function of copper. To sustain normal cellular functions, COA6, SCO1 and SCO2 work together to mediate the transfer of copper to COX in the mitochondrial intermembrane space. copper transport
SCO2 cuproptosis 36882769 Cytochrome c oxidase assembly factor 6(COA6) served as a thiol-disulfide oxidoreductase to reduce the formation of disulfide bonds between cysteine residues in synthesis of cytochrome c oxidase1/2 (SCO1/2) and substances other than copper, thus allowing copper binding. The deficiency of COA6 lead to disorder of respiratory complex IV biogenesis. Driver
SCO2 cuproptosis 36882769 Moreover, SCO1 and SCO2 were also involved in the regulation of cellular copper homeostasis, and the absence of both decreases cellular copper ion levels. Driver
SCO2 cuproptosis 37979442 Cu chaperones deliver Cu to COX, including COX11, COX17, COX19, COX23, SCO1(synthesis of cytochrome C oxidase 1), and SCO2. Cu chaperones
SCO2 cuproptosis 38339398 Synthesis of Cytochrome C Oxidase 1 (SCO1 and SCO2):Delivers copper to COX2 and helps maintain copper homeostasis copper ionophores
SCO2 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
SCO2 cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.45 database.
SCO2 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway
SCO2 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
SCO2 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
SCO2 cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
SCO2 GO:0001654,GO:0001701,GO:0003012,GO:0005507,GO:0005515,GO:0005739,GO:0005739,GO:0005743,GO:0005759,GO:0006878,GO:0014823,GO:0015035,GO:0016531,GO:0022904,GO:0030016,GO:0033617,GO:0033617,GO:0033617

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SCO2 hsa:9997 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SCO2 MT-CO2 15229189 18458339 19393246 26192618 interaction type N/A ACSN
SCO2 MAP3K5 23319048 phosphorylation reaction,stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
E2F4 SCO2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SCO2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 SCO2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000345DEB SCO2 25416803 26309161 mrna cleavage,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001CC379 SCO2 25416803 26309161 mrna cleavage,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SCO2 COX17 25361965 interaction type N/A PTMCode2
COX17 SCO2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPIB SCO2 25348397 N/A physical interaction ComPPI
NDUFAF4 SCO2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
COX17 SCO2 18458339 24234451 25348397 N/A nuclear magnetic resonance,physical interaction ComPPI,IntAct
NONO SCO2 25348397 N/A physical interaction ComPPI
PTPN22 SCO2 25348397 N/A physical interaction ComPPI
CUL3 SCO2 25348397 N/A physical interaction ComPPI
PHKG2 SCO2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ILK SCO2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MYC SCO2 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SPR SCO2 25348397 N/A physical interaction ComPPI
SCP2 SCO2 25348397 N/A physical interaction ComPPI
TUBA1A SCO2 24234451 25348397 29568061 association pull down ComPPI,IntAct
TUBGCP3 SCO2 25348397 N/A physical interaction ComPPI
STX7 SCO2 25348397 N/A physical interaction ComPPI
ATP6V1E1 SCO2 25348397 N/A physical interaction ComPPI
PQBP1 SCO2 25348397 N/A physical interaction ComPPI
TIMM44 SCO2 25348397 N/A physical interaction ComPPI
PTPRN SCO2 25348397 N/A physical interaction ComPPI
TIAL1 SCO2 25348397 N/A physical interaction ComPPI
UBE4B SCO2 25348397 N/A physical interaction ComPPI
CDC25C SCO2 25348397 N/A physical interaction ComPPI
SEPTIN9 SCO2 25348397 N/A physical interaction ComPPI
MAP3K3 SCO2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TGOLN2 SCO2 24234451 25348397 29568061 association pull down ComPPI,IntAct
PPEF1 SCO2 24234451 25348397 28330616 association pull down ComPPI,IntAct
CEP162 SCO2 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIN4 SCO2 25348397 N/A physical interaction ComPPI
TUBGCP2 SCO2 25348397 N/A physical interaction ComPPI
STOM SCO2 25348397 N/A physical interaction ComPPI
MTM1 SCO2 25348397 N/A physical interaction ComPPI
MTMR12 SCO2 25348397 N/A physical interaction ComPPI
AIFM1 SCO2 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
NEDD1 SCO2 25348397 N/A physical interaction ComPPI
VDAC3 SCO2 25348397 N/A physical interaction ComPPI
NDUFA7 SCO2 25348397 N/A physical interaction ComPPI
COQ9 SCO2 25348397 N/A physical interaction ComPPI
SRPRB SCO2 25348397 N/A physical interaction ComPPI
HERC2 SCO2 25348397 N/A physical interaction ComPPI
MTMR4 SCO2 25348397 N/A physical interaction ComPPI
APP SCO2 25348397 N/A physical interaction ComPPI
TP53 SCO2 25348397 N/A physical interaction ComPPI
TJP1 SCO2 25348397 N/A physical interaction ComPPI
HERC2P3 SCO2 25348397 N/A physical interaction ComPPI
ARMC6 SCO2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MT-CO2 SCO2 25348397 N/A physical interaction ComPPI
COX6B1 SCO2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
RIPK4 SCO2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
THY1 SCO2 25348397 N/A physical interaction ComPPI
RIDA SCO2 25348397 N/A physical interaction ComPPI
SBDS SCO2 25348397 N/A physical interaction ComPPI
MRPL53 SCO2 25348397 N/A physical interaction ComPPI
COA6 SCO2 25348397 N/A physical interaction ComPPI
CDV3 SCO2 25348397 N/A physical interaction ComPPI
TANGO2 SCO2 25348397 N/A physical interaction ComPPI
SUGP1 SCO2 25348397 N/A physical interaction ComPPI
SCO2 MAGEA10 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SCO2 CISD3 25348397 N/A physical interaction ComPPI
SCO2 NDUFA4 25348397 N/A physical interaction ComPPI
SCO2 NMES1 25348397 N/A physical interaction ComPPI
SCO2 OPA3 25348397 N/A physical interaction ComPPI
SCO2 EYA4 25348397 N/A physical interaction ComPPI
SCO2 MTMR14 25348397 N/A physical interaction ComPPI
SCO2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SCO2 OXCT1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SCO2 COQ10A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SCO2 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HSCB SCO2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
SMARCB1 SCO2 24234451 30108113 association pull down,proximity-dependent biotin identification IntAct
STK38L SCO2 24234451 30108113 association pull down IntAct

Visualization










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