GeneInfo:
GeneAttribute
GeneDescription
GeneSymbol
SLC31A2
FullNmae
solute carrier family 31 member 2
LocusType
gene with protein product
Status
Approved
HGNC_id
HGNC:11017
EnsembleID
ENSG00000136867
Uniprot
O15432
Protein Structure:
Gene Description in Publicaton:
GeneSymbol
CellDeathType
PMID
Description
GeneType
SLC31A2
pyroptosis
38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
SLC31A2
mpt
38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
SLC31A2
immunogenic
38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
SLC31A2
cuproptosis
38538282 Our analysis found that cg05706061 contained in prognosis signature was located in the promoter region of the cuproptosis-related gene SLC31A2.
retulator signature
SLC31A2
cuproptosis
38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes.
63 cuproptosis-related genes
SLC31A2
cuproptosis
38348451 Copper transporters. Essential for copper homeostasis and their dysregulation can influence cuproptosis susceptibility.
CRGs in the cuproptosis pathway
SLC31A2
cuproptosis
35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION).
Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.29 database.
SLC31A2
cuproptosis
36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1.
Genes related to copper homeostasis pathway
SLC31A2
cuproptosis
36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13)
43 cuproptosis-related genes in the study
SLC31A2
cuproptosis
36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications.
cuproptosis-related genes
SLC31A2
autosis
38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore)
retulator signature
Go Annotation:
GeneSymbol
Go id
SLC31A2
GO:0005375,GO:0005515,GO:0005765,GO:0005886,GO:0006825,GO:0006878,GO:0015677,GO:0031902,GO:0035434,GO:0055037,GO:1902311
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source
Target
Pmid
Interactiontype
Methods
Database
AR
SLC31A2
20610535
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
ESR1
SLC31A2
21878914
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
ETS1
SLC31A2
18971253
20019798
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
GATA3
SLC31A2
21878914
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
FOXA1
SLC31A2
18971253
21878914
trascriptional regulation,stimulation
inferred by curator,chromatin immunoprecipitation assay
TFlink
YBX1
SLC31A2
19151767
trascriptional regulation,stimulation
chromatin immunoprecipitation assay
TFlink
TP53
SLC31A2
18922183
trascriptional regulation,stimulation
chromatin immunoprecipitation array
TFlink
SMARCA4
SLC31A2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CEBPA
SLC31A2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
CTCF
SLC31A2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
FOXP1
SLC31A2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
HNF4A
SLC31A2
18971253
trascriptional regulation,stimulation
inferred by curator
TFlink
Source
Target
Pmid
Interactiontype
Methods
Database
BNIP3
SLC31A2
24234451
25348397
physical association
two hybrid,two hybrid array,two hybrid prey pooling approach
ComPPI,IntAct
F2RL1
SLC31A2
24234451
28298427
physical association
ubiquitin reconstruction
IntAct
HTR2B
SLC31A2
24234451
28298427
physical association
ubiquitin reconstruction
IntAct
OPRL1
SLC31A2
24234451
28298427
physical association
ubiquitin reconstruction
IntAct
Visualization
