Gene Information gene info

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GENE：AQP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AQP2
FullNmae aquaporin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:634
EnsembleID ENSG00000167580
Uniprot P41181

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AQP2 cuproptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
AQP2 cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.7 database.

Go Annotation:

GeneSymbol Go id
AQP2 GO:0003091,GO:0003091,GO:0003097,GO:0005372,GO:0005515,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006833,GO:0006833,GO:0006833,GO:0007015,GO:0015168,GO:0015250,GO:0015250,GO:0015250,GO:0015793,GO:0016020,GO:0016323,GO:0016324,GO:0016324,GO:0016324,GO:0030658,GO:0042631,GO:0048471,GO:0051289,GO:0055037,GO:0070062,GO:0070062,GO:0071280,GO:0071288,GO:0072205,GO:0098576

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AQP2 hsa:359 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 AQP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 AQP2 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 AQP2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
AR AQP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AQP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 AQP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AQP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF AQP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 AQP2 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A AQP2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C770D AQP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB AQP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000022AAA AQP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001ADE63 AQP2 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA AQP2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
TMEM218 AQP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ACTB AQP2 25348397 N/A physical interaction ComPPI
RTP2 AQP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
OLFM4 AQP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LHFPL5 AQP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
INSIG2 AQP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TM9SF2 AQP2 25348397 N/A physical interaction ComPPI
EEF1A1 AQP2 25348397 N/A physical interaction ComPPI
EFNA5 AQP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IER3 AQP2 25348397 N/A physical interaction ComPPI
STX8 AQP2 25348397 N/A physical interaction ComPPI
AQP2 NDFIP2 25348397 N/A physical interaction ComPPI
AQP2 BCAP31 25348397 N/A physical interaction ComPPI
AQP2 TMEM230 25348397 N/A physical interaction ComPPI
AQP2 SPCS1 25348397 N/A physical interaction ComPPI
AQP2 PLP2 25348397 N/A physical interaction ComPPI
AQP2 UBE2J1 25348397 N/A physical interaction ComPPI
AQP2 CCDC167 25348397 N/A physical interaction ComPPI
AQP2 ERG28 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 SSR3 25348397 N/A physical interaction ComPPI
AQP2 CERT1 25348397 N/A physical interaction ComPPI
AQP2 CLDN7 25348397 N/A physical interaction ComPPI
AQP2 C4ORF3 25348397 N/A physical interaction ComPPI
AQP2 EEF1A1P5 25348397 N/A physical interaction ComPPI
AQP2 SLC5A2 25348397 N/A physical interaction ComPPI
AQP2 SNX5 25348397 N/A physical interaction ComPPI
AQP2 ELL2 25348397 N/A physical interaction ComPPI
AQP2 VAPB 25348397 N/A physical interaction ComPPI
AQP2 SUPT20H 25348397 N/A physical interaction ComPPI
AQP2 GPAA1 25348397 N/A physical interaction ComPPI
AQP2 NEDD4 25348397 N/A physical interaction ComPPI
AQP2 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 YIPF6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 MS4A13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 OR10AG1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 TMEM97 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 SNAP47 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 TMEM60 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 TMEM86A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 ERMP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 PNLIPRP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 CDIPT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 SLC30A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 SLC38A7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 IGFBP5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 TMEM109 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 TMEM236 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 GPX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 PANX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 PDZK1IP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 LEUTX 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP2 CREB3 25348397 N/A two hybrid bait and prey pooling approach ComPPI
AQP2 AQP2 11076974 12051765 14525934 N/A experimental interaction detection HPRD
AQP2 TRPC3 17699554 20107112 27898060 N/A N/A OmniPath
PRKACA AQP2 11042132 11067864 11076974 12194985 14519593 16120822 16303856 17138647 17940053 17965877 18042467 18664568 19357255 22778181 27898060 stimulant N/A OmniPath
PRKCA AQP2 10710543 18434387 27898060 N/A N/A OmniPath

Visualization










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