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GENE：BACE1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BACE1
FullNmae beta-secretase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:933
EnsembleID ENSG00000186318
Uniprot P56817

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BACE1 cuproptosis 36466876 Overall, 25 CuDEGs were identified, including ABCB6, BACE1, FDX1, GLS, LIAS, MT1M, PDHA1, etc. retulator signature
BACE1 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
BACE1 cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.2 database.

Go Annotation:

GeneSymbol Go id
BACE1 GO:0001540,GO:0004175,GO:0004190,GO:0005515,GO:0005764,GO:0005768,GO:0005768,GO:0005769,GO:0005770,GO:0005771,GO:0005788,GO:0005794,GO:0005802,GO:0005802,GO:0005886,GO:0005886,GO:0005886,GO:0006508,GO:0006509,GO:0006509,GO:0006509,GO:0008021,GO:0008233,GO:0008798,GO:0009986,GO:0009986,GO:0010008,GO:0010288,GO:0016020,GO:0016485,GO:0019899,GO:0030424,GO:0030425,GO:0034205,GO:0042987,GO:0043025,GO:0043525,GO:0045121,GO:0050435,GO:0050435,GO:0050966,GO:0055037,GO:0060134,GO:0070931,GO:0071280,GO:0071287,GO:0098686,GO:0099171,GO:0140448,GO:1904646,GO:1990000

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BACE1 hsa:23621 path:hsa05010 Alzheimer disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFATC4 BACE1 23180781 25663301 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR BACE1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 BACE1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 BACE1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 BACE1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 BACE1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 BACE1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA BACE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BACE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BACE1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA1 BACE1 12815710 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 BACE1 17385716 trascriptional regulation,stimulation inferred by curator TFlink
RELA BACE1 17385716 trascriptional regulation,stimulation inferred by curator TFlink
SP1 BACE1 15681800 15857888 21712774 22275252 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 BACE1 15681800 15857888 21712774 22275252 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A BACE1 15059977 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000008F0CF BACE1 18234899 20489155 \N rna interference,inhibition array technology,experimental interaction detection,western blot,northern blot,miRNA interference luciferase reporter assay miRSponge
URS0000171CD1 BACE1 N/A 18434550 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS0000076995 BACE1 N/A 18434550 \N rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS0000272A3D BACE1 21565331 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr miRSponge
URS00005FDE70 BACE1 18716028 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000008F0CF BACE1 18234899 18927107 20489155 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,northern blot,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000076995 BACE1 18434550 18927107 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00005FDE70 BACE1 18716028 18927107 18986979 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000171CD1 BACE1 18434550 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS0000272A3D BACE1 21565331 25416803 25973041 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 BACE1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA BACE1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003FD55 BACE1 24352696 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000061E50F BACE1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004505E4 BACE1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A BACE1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK1D BACE1 22135298 phosphorylation N/A PhosphoSite
MAPK14 BACE1 22135298 phosphorylation N/A PhosphoSite
CDK5 BACE1 22135298 phosphorylation N/A PhosphoSite
CSNK1A1 BACE1 22135298 phosphorylation N/A PhosphoSite
ROCK2 BACE1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
FBXO2 BACE1 25348397 N/A physical interaction ComPPI
CSNK1D BACE1 11278841 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
GGA2 BACE1 12135764 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
COPS5 BACE1 25348397 N/A physical interaction ComPPI
PLSCR1 BACE1 12586838 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PDIA3 BACE1 14525934 15606899 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
FURIN BACE1 10887202 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SELPLG BACE1 14507929 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KCNQ1 BACE1 25348397 N/A physical interaction ComPPI
PSAP BACE1 14525934 15606899 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
LRP1 BACE1 14525934 15749709 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
RANBP9 BACE1 14525934 15606899 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ATP1B1 BACE1 14525934 15606899 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
NCSTN BACE1 12054507 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
USP8 BACE1 25348397 N/A physical interaction ComPPI
GGA3 BACE1 25348397 N/A physical interaction ComPPI
GGA1 BACE1 14567678 15117318 15466887 15886016 25348397 27898060 N/A physical interaction ComPPI,OmniPath
BACE1 ITM2C 14525934 15606899 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BACE1 KHSRP 14525934 15606899 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
BACE1 CMPK1 14525934 15606899 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
BACE1 MMP2 12586836 14525934 24234451 25241761 25348397 27898060 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct,OmniPath
BACE1 BRI3 14525934 15606899 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
BACE1 PSEN1 12901838 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
BACE1 PCSK9 25348397 N/A physical interaction ComPPI
BACE1 APP 10531052 14525934 22801501 24234451 25348397 cleavage reaction experimental interaction detection,physical interaction,fluorescence microscopy,cleavage assay ComPPI,HPRD,IntAct
BACE1 MOV10 25348397 N/A physical interaction ComPPI
BACE1 NXF1 25348397 N/A physical interaction ComPPI
BACE1 STUB1 25348397 25773675 27898060 N/A physical interaction ComPPI,OmniPath
BACE1 SCGB1D4 25348397 N/A physical interaction ComPPI
BACE1 SORT1 25348397 N/A physical interaction ComPPI
BACE1 FLOT2 24234451 24612608 25348397 association,physical association anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct
BACE1 FLOT1 24234451 24612608 25348397 physical association proximity ligation assay ComPPI,IntAct
ADRB2 BACE1 24234451 28298427 physical association ubiquitin reconstruction IntAct
CDK5 BACE1 26317805 27898060 N/A N/A OmniPath
CSNK1A1 BACE1 11278841 11860271 15615712 24305806 27898060 N/A N/A OmniPath
BACE1 APP 10531052 20418918 22801501 27898060 stimulant N/A OmniPath
CSNK1D BACE1 11278841 25241761 27898060 N/A N/A OmniPath
FURIN BACE1 10887202 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS0000776338 BACE1 20236612 21785702 27087310 direct interaction,inhibition N/A NPInter
URS00007E3977 BACE1 18587408 28529080 direct interaction,inhibition experimental interaction detection lncRInter

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