GENE：CYP1A1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CYP1A1 |
| FullNmae | cytochrome P450 family 1 subfamily A member 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2595 |
| EnsembleID | ENSG00000140465 |
| Uniprot | P04798 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CYP1A1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CYP1A1 | cuproptosis | 36838613 | Among them, HMOX1, CYP1A1, HMGCS2, LCN2, and MTTP may play an essential role in metal ion homeostasis. | retulator signature |
| CYP1A1 | cuproptosis | 35964468 | By LASSO and COX regressions, 12 prognosis-related cuproptosis genes were further selected and their HR was obtained. | cuproptosis-related genes |
| CYP1A1 | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.0 database. |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CYP1A1 | GO:0001666,GO:0001676,GO:0002933,GO:0004497,GO:0004497,GO:0005506,GO:0005515,GO:0005743,GO:0005789,GO:0006631,GO:0006694,GO:0006778,GO:0006805,GO:0008202,GO:0008210,GO:0008391,GO:0009308,GO:0009624,GO:0009635,GO:0009692,GO:0009804,GO:0009812,GO:0010041,GO:0016491,GO:0016679,GO:0016711,GO:0017143,GO:0019341,GO:0019373,GO:0019825,GO:0019899,GO:0020037,GO:0030544,GO:0032094,GO:0032451,GO:0032496,GO:0033189,GO:0035902,GO:0042359,GO:0042572,GO:0042572,GO:0042759,GO:0042904,GO:0043010,GO:0043231,GO:0046685,GO:0048565,GO:0050665,GO:0051879,GO:0055093,GO:0060137,GO:0070330,GO:0070365,GO:0070576,GO:0071280,GO:0071407,GO:0097267,GO:0101020,GO:0101021,GO:0102033,GO:0106256,GO:0120319,GO:1900087 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CYP1A1 | hsa:1543 | path:hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| CYP1A1 | hsa:1543 | path:hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| CYP1A1 | hsa:1543 | path:hsa00830 | Retinol metabolism - Homo sapiens (human) |
| CYP1A1 | hsa:1543 | path:hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| CYP1A1 | hsa:1543 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| CYP1A1 | hsa:1543 | path:hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| CYP1A1 | hsa:1543 | path:hsa05204 | Chemical carcinogenesis - DNA adducts - Homo sapiens (human) |
| CYP1A1 | hsa:1543 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| CYP1A1 | hsa:1543 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| CYP1A1 | hsa:1543 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AHR | CYP1A1 | 10359656 12213390 12376470 15325265 16972788 17012224 17785579 19376845 21357676 24639079 8631128 9698073 9865727 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| BRCA1 | CYP1A1 | 16567799 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| E2F4 | CYP1A1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | CYP1A1 | 15837795 16972788 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | CYP1A1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CYP1A1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | CYP1A1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | CYP1A1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PPARA | CYP1A1 | 15521013 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| RXRA | CYP1A1 | 15521013 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| FOXP3 | CYP1A1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| CEBPA | CYP1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | CYP1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CYP1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CYP1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | CYP1A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ARNT | CYP1A1 | 12376470 19255421 19376845 22387692 8631128 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KLF4 | CYP1A1 | 9651398 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | CYP1A1 | 10490621 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | CYP1A1 | 19928584 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | CYP1A1 | 15325265 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | CYP1A1 | 19928584 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF1 | CYP1A1 | 9388470 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | CYP1A1 | 22837390 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AR | CYP1A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | CYP1A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | CYP1A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001C3AC1 | CYP1A1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000116F83 | CYP1A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032BDF4 | CYP1A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043C1C3 | CYP1A1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000338542 | CYP1A1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E1A16 | CYP1A1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000140295 | CYP1A1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000136174 | CYP1A1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000101787 | CYP1A1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000055BBE5 | CYP1A1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171525 | CYP1A1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012A1DD | CYP1A1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PIN1 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| TXLNA | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| HPCAL1 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| TPP2 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| MCM2 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| HPCAL4 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| PTPN11 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP1R8 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| CPNE1 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| PKN2 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| GTF2I | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| PICALM | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| USO1 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| EIF2AK2 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| SNX2 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| TLN1 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| HDLBP | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| IQGAP1 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| ADD3 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| PKM | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| TSFM | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| CYB5A | CYP1A1 | 14525934 25348397 6102994 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CYP1A1 | CMTM5 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| CYP1A1 | MMUT | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | GSTK1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | NAA15 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | PSME1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | SF3A1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | DIS3 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | VRK1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | ACADVL | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | NUP35 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | RPRD1A | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | LETM1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | CYB5R3 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | SBDS | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | NAA50 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | EIF4G2 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | AFDN | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | OSBPL9 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | EIF2S2 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | OTUB1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | QKI | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | ETF1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | RECQL | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | CTNNBL1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | CKAP5 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | MCTS1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | EIF2A | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | RBM12 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | CSTF3 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | CLN5 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | CSTF1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | CAB39 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | ZMPSTE24 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | ZNF503 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | TCEA1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | BRD4 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | RAVER1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | SNX3 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | DTD1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | NSDHL | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | MINPP1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | EMG1 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | TBCE | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | EIF3J | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | ACTBL2 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A1 | SYAP1 | 25348397 | N/A | physical interaction | ComPPI |
| PYGB | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| NUCB1 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| CSTF2 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |
| PSMF1 | CYP1A1 | 25348397 | N/A | physical interaction | ComPPI |