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GENE：MT1A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MT1A
FullNmae metallothionein 1A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7393
EnsembleID ENSG00000205362
Uniprot P04731

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MT1A cuproptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MT1A cuproptosis 38408075 We retrieved 21 genes involved in Cuproptosis from the literature, including CDKN2A, DLD, DLAT, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, and PDHB, ATB7B, CUTC, GRX1, MT1A, MT2A, MT3, XIAP, ATM, PRNP, P53, and SP1. genes involved in Cuproptosis
MT1A cuproptosis 38408075 We showed the mechanism of action of these genes in Cuproptosis. Excess Cu2+ stimulates the activation of ATM which activates SP1 and P53. P53 promotes PRNP, MT1A, MT2A and MT3A to expel Cu2+ out of the cell. suppressor
MT1A cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.8 database.
MT1A cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway
MT1A cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study

Go Annotation:

GeneSymbol Go id
MT1A GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0006882,GO:0008270,GO:0010273,GO:0045926,GO:0046872,GO:0071276,GO:0071276,GO:0071280,GO:0071294,GO:0071294

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MT1A hsa:4489 path:hsa04978 Mineral absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 MT1A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
E2F4 MT1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MT1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MT1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MT1A N/A trascriptional regulation,stimulation inferred by curator TFlink
FOS MT1A N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN MT1A N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC MT1A N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A MT1A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000381CEC MT1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F74F1 MT1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F859B MT1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000519450 MT1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EC1BE MT1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 MT1A 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA MT1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 MT1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB MT1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 MT1A 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ARRB1 MT1A 16778767 24234451 25348397 physical association bioluminescence resonance energy transfer ComPPI,IntAct
GNAI1 MT1A 16778767 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TP53 MT1A 16442532 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath

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