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GENE：MT1E

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MT1E
FullNmae metallothionein 1E
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7397
EnsembleID ENSG00000169715
Uniprot P04732

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MT1E cuproptosis 38211899 Finally, a new cuproptosis-OXPHOS prognostic signature (CNN2, ATP6V0E1, PSMD6, CCDC25, IGFBP2, MT1E, and RPS4Y1) was constructed for the prediction of the prognosis. retulator signature
MT1E cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
MT1E cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.10 database.
MT1E cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Genes of iron-sulfur cluster related proteins
MT1E cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
MT1E cuproptosis 36072790 It was found that among multiple MT subtypes,聽MT1E聽was significantly upregulated in transcription after copper treatment, and its expression change can be used as an indicator of intracellular copper ion variation. indicator of intracellular copper ion variation聽

Go Annotation:

GeneSymbol Go id
MT1E GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0006882,GO:0008270,GO:0010273,GO:0045926,GO:0046872,GO:0071276,GO:0071276,GO:0071280,GO:0071294,GO:0071294

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MT1E hsa:4493 path:hsa04978 Mineral absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YBX1 MT1E 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 MT1E 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 MT1E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXF2 MT1E 19562724 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F6E49 MT1E 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000045DBD MT1E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E MT1E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF MT1E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF MT1E 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E1509 MT1E 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 MT1E 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000040780F MT1E 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000008A99 MT1E 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032BDF4 MT1E 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 MT1E 25348397 N/A physical interaction ComPPI

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