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GENE：COMMD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COMMD1
FullNmae copper metabolism domain containing 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:23024
EnsembleID ENSG00000173163
Uniprot Q8N668

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COMMD1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
COMMD1 cuproptosis 39198750 XIAP, the target of triptolide, played a role in cuproptosis by regulating COMMD1. retulator signature
COMMD1 cuproptosis 38339398 Copper Metabolism Domain-Containing 1 (COMMD1):Involved in hepatic copper homeostasis copper ionophores
COMMD1 cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.30 database.
COMMD1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway

Go Annotation:

GeneSymbol Go id
COMMD1 GO:0005507,GO:0005515,GO:0005546,GO:0005547,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005829,GO:0006289,GO:0006893,GO:0010008,GO:0015031,GO:0019871,GO:0031398,GO:0031398,GO:0031462,GO:0032088,GO:0032088,GO:0032434,GO:0032434,GO:0042802,GO:0042803,GO:0043325,GO:0048227,GO:0055037,GO:0055070,GO:0055070,GO:0070300,GO:0080025,GO:1902306,GO:1902306,GO:1902306,GO:2000009,GO:2000009

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
COMMD1 XIAP 14685266 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,two hybrid,ubiquitination reaction InnateDB
NFKBIA COMMD1 14685242 23180781 physical association anti tag coimmunoprecipitation InnateDB
COMMD1 RELA 14685242 23180781 physical association anti tag coimmunoprecipitation InnateDB
CUL1 COMMD1 14685242 23180781 physical association anti tag coimmunoprecipitation InnateDB
COMMD1 BIRC3 14685266 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR COMMD1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 COMMD1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 COMMD1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C COMMD1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 COMMD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000016914 COMMD1 25416803 26586569 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CUL5 COMMD1 25348397 N/A physical interaction ComPPI
VCP COMMD1 25348397 N/A physical interaction ComPPI
E2F6 COMMD1 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
CCDC22 COMMD1 23563313 24234451 25348397 26496610 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,confocal microscopy,tandem affinity purification ComPPI,IntAct
XIAP COMMD1 14525934 14685242 18795889 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
RAD21 COMMD1 25348397 N/A physical interaction ComPPI
FAM167A COMMD1 25348397 N/A physical interaction ComPPI
SOCS1 COMMD1 14525934 17183367 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
REL COMMD1 15799966 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TTF2 COMMD1 25348397 N/A physical interaction ComPPI
EP300 COMMD1 25348397 N/A physical interaction ComPPI
HIF1A COMMD1 25348397 N/A physical interaction ComPPI
LIG4 COMMD1 25348397 N/A physical interaction ComPPI
SPP1 COMMD1 25348397 N/A physical interaction ComPPI
CUL3 COMMD1 25348397 N/A physical interaction ComPPI
CLU COMMD1 25348397 N/A physical interaction ComPPI
CDKN2A COMMD1 18305112 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UBC COMMD1 17183367 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NFKBIA COMMD1 14525934 14685242 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
SCNN1G COMMD1 14645214 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
CFTR COMMD1 21483833 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RELA COMMD1 14525934 14685242 15799966 17183367 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,confocal microscopy ComPPI,HPRD,IntAct
CUL2 COMMD1 14525934 17183367 23563313 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
CUL4B COMMD1 25348397 N/A physical interaction ComPPI
CUL1 COMMD1 14525934 14685242 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CUL4A COMMD1 25348397 N/A physical interaction ComPPI
SCNN1B COMMD1 14645214 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
BCR COMMD1 25348397 N/A physical interaction ComPPI
HSPA4 COMMD1 25348397 N/A physical interaction ComPPI
TFDP1 COMMD1 24234451 25348397 27705803 association physical interaction,tandem affinity purification ComPPI,IntAct
NFYC COMMD1 25348397 N/A physical interaction ComPPI
KAT2A COMMD1 25348397 N/A physical interaction ComPPI
ELOC COMMD1 17183367 23563313 24234451 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
COMMD1 COMMD2 14525934 15799966 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
COMMD1 COMMD3 14525934 15799966 23563313 24234451 25348397 association,physical association experimental interaction detection,pull down,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
COMMD1 COMMD4 14525934 15799966 23563313 24234451 25348397 association,physical association experimental interaction detection,pull down,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
COMMD1 COMMD6 14525934 15799966 23563313 24234451 25348397 25416956 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,two hybrid array,in vitro,tandem affinity purification,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
COMMD1 COMMD7 14525934 15799966 24234451 25348397 26060140 26344197 27898060 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
COMMD1 COMMD8 14525934 15799966 23563313 24234451 25348397 association,physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
COMMD1 COMMD10 14525934 15799966 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
COMMD1 COMMD5 14525934 15799966 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
COMMD1 CUL7 25348397 N/A physical interaction ComPPI
COMMD1 SCNN1D 14645214 21741370 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct,OmniPath
COMMD1 AKT1 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
COMMD1 SGK1 25348397 N/A physical interaction ComPPI
COMMD1 NAIP 25348397 N/A physical interaction ComPPI
COMMD1 BIRC3 25348397 N/A physical interaction ComPPI
COMMD1 CDKN2A 25348397 N/A physical interaction ComPPI
COMMD1 NMRAL1 25348397 N/A physical interaction ComPPI
COMMD1 SOD1 20595380 24691167 25348397 27898060 N/A physical interaction ComPPI,OmniPath
COMMD1 ATP7B 12968035 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
COMMD1 RELB 15799966 24234451 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
COMMD1 NFKB1 15799966 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
COMMD1 NFKB2 15799966 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
COMMD1 ATP7A 25348397 N/A physical interaction ComPPI
COMMD1 BARD1 25348397 N/A physical interaction ComPPI
COMMD1 BRCA1 25348397 N/A physical interaction ComPPI
COMMD1 SLC12A2 23515529 25348397 27898060 N/A physical interaction ComPPI,OmniPath
COMMD1 BAHCC1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
COMMD1 CCDC93 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COMMD1 VPS35L 25348397 N/A physical interaction ComPPI
COMMD1 SCLT1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COMMD1 PRKN 25348397 N/A physical interaction ComPPI
COMMD1 DENND10 25348397 N/A physical interaction ComPPI
COMMD1 COMMD9 25348397 N/A physical interaction ComPPI
COMMD1 VPS26C 25348397 N/A physical interaction ComPPI
COMMD1 VPS29 25348397 N/A physical interaction ComPPI
COMMD1 VPS33B 25348397 N/A physical interaction ComPPI
COMMD1 STK11IP 25348397 N/A physical interaction ComPPI
COMMD1 KIF2B 25348397 N/A physical interaction ComPPI
COMMD1 TRIM16L 25348397 N/A physical interaction ComPPI
COMMD1 G6PD 25348397 N/A physical interaction ComPPI
COMMD1 ATAD3C 25348397 N/A physical interaction ComPPI
COMMD1 TBC1D4 25348397 N/A physical interaction ComPPI
COMMD1 TRIM25 25348397 N/A physical interaction ComPPI
COMMD1 FAM107A 25348397 N/A physical interaction ComPPI
COMMD1 TCEAL8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMMD1 UPRT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COMMD1 COMMD1 14525934 15799966 24234451 physical association experimental interaction detection,pull down HPRD,IntAct
COMMD1 NFKBIA 14685242 16573520 20068069 25520503 27898060 N/A N/A OmniPath
COMMD1 BIRC3 14685266 27898060 N/A N/A OmniPath
RELA COMMD1 14685242 15799966 16573520 17183367 19270718 19339690 20048074 25074812 27898060 N/A N/A OmniPath
COMMD1 RELA 14685242 15799966 16573520 17183367 19270718 19339690 20048074 25074812 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009AD162 COMMD1 27087310 direct interaction,inhibition N/A NPInter

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