GENE：SLC11A2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC11A2 |
| FullNmae | solute carrier family 11 member 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10908 |
| EnsembleID | ENSG00000110911 |
| Uniprot | P49281 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC11A2 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC11A2 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| SLC11A2 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| SLC11A2 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC11A2 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| SLC11A2 | cuproptosis | 37055935 | In addition, copper uptake by SLC11A2/DMT1 (solute carrier family 11 member 2) may be a compensatory mechanism for SLC31A1 deficiency. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC11A2 | GO:0001666,GO:0005375,GO:0005381,GO:0005384,GO:0005384,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005765,GO:0005765,GO:0005765,GO:0005769,GO:0005769,GO:0005773,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006783,GO:0006824,GO:0006825,GO:0006826,GO:0006828,GO:0006879,GO:0007611,GO:0009986,GO:0010039,GO:0015086,GO:0015086,GO:0015087,GO:0015093,GO:0015093,GO:0015093,GO:0015093,GO:0015094,GO:0015094,GO:0015099,GO:0015295,GO:0015692,GO:0016020,GO:0016324,GO:0031410,GO:0031526,GO:0031901,GO:0031902,GO:0031902,GO:0033212,GO:0033212,GO:0034755,GO:0035434,GO:0035444,GO:0045177,GO:0045177,GO:0045178,GO:0046870,GO:0046870,GO:0046915,GO:0048471,GO:0048813,GO:0048821,GO:0055037,GO:0055037,GO:0055038,GO:0060586,GO:0060586,GO:0070574,GO:0070826,GO:0071421,GO:1902600,GO:1903561,GO:1903561 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC11A2 | hsa:4891 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| SLC11A2 | hsa:4891 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
| SLC11A2 | hsa:4891 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
| SLC11A2 | hsa:4891 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| SLC11A2 | hsa:4891 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLC11A2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | SLC11A2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | SLC11A2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | SLC11A2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | SLC11A2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | SLC11A2 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | SLC11A2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP53 | SLC11A2 | 18922183 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | SLC11A2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | SLC11A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC11A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLC11A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SLC11A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC11A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SLC11A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | SLC11A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLC11A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SLC11A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000A07C1 | SLC11A2 | 20410187 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00000A07C1 | SLC11A2 | 20410187 23313552 23592263 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS00001EFEC1 | SLC11A2 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00005651EE | SLC11A2 | 20371350 23622248 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clash | TarBase |
| URS00000BE495 | SLC11A2 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00003380CC | SLC11A2 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002C02E4 | SLC11A2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000338542 | SLC11A2 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B0E50 | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037E170 | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E1A16 | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000010F787 | SLC11A2 | 23313552 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D814 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171525 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015A0D9 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CCD18 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000486E0B | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000331800 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B0920 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003FD55 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDAA | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AC389 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016D2D4 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075E2C3 | SLC11A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C1E1 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A8BC6 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032AE90 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E5ECC | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C0099 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D4175 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FBC84 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041FA2C | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5969 | SLC11A2 | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000047A67D | SLC11A2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ACA7C | SLC11A2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBB | SLC11A2 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| UBC | SLC11A2 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| RPS27A | SLC11A2 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| UBA52 | SLC11A2 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| NEDD4L | SLC11A2 | 19706893 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRKN | SLC11A2 | 20089134 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| NEDD4 | SLC11A2 | 25348397 | N/A | physical interaction | ComPPI |
| VPS35 | SLC11A2 | 25348397 | N/A | physical interaction | ComPPI |
| NDFIP1 | SLC11A2 | 18776082 19706893 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct,OmniPath |
| MT-CO2 | SLC11A2 | 24234451 24448823 25348397 27898060 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct,OmniPath |
| NDFIP2 | SLC11A2 | 25348397 | N/A | physical interaction | ComPPI |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00009B4F1C | SLC11A2 | 27087310 | direct interaction,inhibition | N/A | NPInter |