GENE:COX17
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | COX17 |
FullNmae | cytochrome c oxidase copper chaperone COX17 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:2264 |
EnsembleID | ENSG00000138495 |
Uniprot | Q14061 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
COX17 | cuproptosis | 36276096 | This study aimed to evaluate the pan-cancer genomics and clinical association of cuproptosis and copper metabolism-related cell death genes, including SLC25A3, SLC25A37, SLC31A1, FDX1, DLAT, LIAS, ATP7A, ATP7B, COX17, SCO1, SCO2, COX11, and COX19. | retulator signature |
COX17 | cuproptosis | 36882769 | The entry and departure of copper ions into and out of the cell are controlled by the copper ion transporters SLC31A1 and ATP7B, whereas the transit of copper ions through the outer and inner mitochondrial membranes is controlled by COX17 and SLC25A3, respectively. | transit of copper ions |
COX17 | cuproptosis | 36882769 | Cytochrome c oxidase copper chaperone(COX17) carried copper ions from the cytoplasm into the intermembrane space of mitochondria, and further delivered copper ions to the cysteine residues of SCO1 with which it formed disulfide bonds. | transported copper |
COX17 | cuproptosis | 37979442 | Cu chaperones deliver Cu to COX, including COX11, COX17, COX19, COX23, SCO1(synthesis of cytochrome C oxidase 1), and SCO2. | Cu chaperones |
COX17 | cuproptosis | 38339398 | Cytochrome C Oxidase Copper Chaperone (COX17):Delivers mitochondrial copper | copper ionophores |
COX17 | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
COX17 | cuproptosis | 38348451 | COX17 involved in copper delivery to cytochrome c oxidase and are crucial for mitochondrial function. | CRGs in the cuproptosis pathway |
COX17 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
COX17 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
COX17 | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
COX17 | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
Go Annotation:
GeneSymbol | Go id |
---|---|
COX17 | GO:0005507,GO:0005515,GO:0005737,GO:0005758,GO:0005758,GO:0006091,GO:0006825,GO:0008047,GO:0008284,GO:0016531,GO:0016531,GO:0016531,GO:0033617,GO:0033617,GO:0043167,GO:1903136,GO:1904960 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
COX17 | hsa:10063 | path:hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
COX17 | hsa:10063 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
COX17 | hsa:10063 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | COX17 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
E2F4 | COX17 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
ETS1 | COX17 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
SMARCA4 | COX17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | COX17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | COX17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | COX17 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS000021D7C8 | COX17 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS0000237AF9 | COX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001DE669 | COX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000005CF5F | COX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000065D58 | COX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002A79D1 | COX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000039607D | COX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004959F4 | COX17 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
LGALS3 | COX17 | 25348397 | N/A | physical interaction | ComPPI |
KRTAP10-8 | COX17 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
CFL1 | COX17 | 25348397 | N/A | physical interaction | ComPPI |
KATNAL1 | COX17 | 14525934 16189514 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid | ComPPI,HPRD,IntAct |
COX17 | EEF1A1 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
COX17 | UNC119 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
COX17 | ERG28 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
COX17 | LRIF1 | 14525934 16169070 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
COX17 | RBM48 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
COX17 | COPS6 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
COX17 | PPBP | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
COX17 | EEF1A1P5 | 25348397 | N/A | physical interaction | ComPPI |
COX17 | TP53 | 14525934 16169070 24234451 25348397 | physical association | physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
COX17 | COX14 | 24234451 25348397 29568061 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
COX17 | COA1 | 25348397 | N/A | physical interaction | ComPPI |
COX17 | HADHB | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
COX17 | PCMT1 | 25348397 | N/A | physical interaction | ComPPI |
COX17 | SOD1 | 25348397 | N/A | physical interaction | ComPPI |
COX17 | SPR | 25348397 | N/A | physical interaction | ComPPI |
COX17 | TKT | 25348397 | N/A | physical interaction | ComPPI |
COX17 | UFC1 | 25348397 | N/A | physical interaction | ComPPI |
COX17 | SCYL2 | 25348397 | N/A | physical interaction | ComPPI |
COX17 | TALDO1 | 25348397 | N/A | physical interaction | ComPPI |
COX17 | TBCA | 25348397 | N/A | physical interaction | ComPPI |
COX17 | SCO1 | 18458339 24234451 25348397 29568061 | association | mass spectrometry studies of complexes,nuclear magnetic resonance,physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
COX17 | SCO2 | 18458339 24234451 25348397 | N/A | nuclear magnetic resonance,physical interaction | ComPPI,IntAct |
COX17 | CHCHD4 | 15359280 15989955 19182799 20026652 25348397 27898060 | N/A | nuclear magnetic resonance,pull down,physical interaction,oxidoreductase assay | ComPPI,OmniPath |
COX17 | RIF1 | 16169070 24234451 25348397 | physical association | two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
COX17 | SUMO2 | 16169070 24234451 25348397 | physical association | two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
COX17 | AIFM1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
COX17 | SFXN1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
MIF | COX17 | 25348397 | N/A | physical interaction | ComPPI |
PLGRKT | COX17 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
COX17 | COX17 | 11170391 14525934 | N/A | experimental interaction detection | HPRD |