Gene Information gene info

GENE:COX17

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COX17
FullNmae cytochrome c oxidase copper chaperone COX17
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2264
EnsembleID ENSG00000138495
Uniprot Q14061

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COX17 cuproptosis 36276096 This study aimed to evaluate the pan-cancer genomics and clinical association of cuproptosis and copper metabolism-related cell death genes, including SLC25A3, SLC25A37, SLC31A1, FDX1, DLAT, LIAS, ATP7A, ATP7B, COX17, SCO1, SCO2, COX11, and COX19. retulator signature
COX17 cuproptosis 36882769 The entry and departure of copper ions into and out of the cell are controlled by the copper ion transporters SLC31A1 and ATP7B, whereas the transit of copper ions through the outer and inner mitochondrial membranes is controlled by COX17 and SLC25A3, respectively. transit of copper ions
COX17 cuproptosis 36882769 Cytochrome c oxidase copper chaperone(COX17) carried copper ions from the cytoplasm into the intermembrane space of mitochondria, and further delivered copper ions to the cysteine residues of SCO1 with which it formed disulfide bonds. transported copper
COX17 cuproptosis 37979442 Cu chaperones deliver Cu to COX, including COX11, COX17, COX19, COX23, SCO1(synthesis of cytochrome C oxidase 1), and SCO2. Cu chaperones
COX17 cuproptosis 38339398 Cytochrome C Oxidase Copper Chaperone (COX17):Delivers mitochondrial copper copper ionophores
COX17 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
COX17 cuproptosis 38348451 COX17 involved in copper delivery to cytochrome c oxidase and are crucial for mitochondrial function. CRGs in the cuproptosis pathway
COX17 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway
COX17 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
COX17 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
COX17 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
COX17 GO:0005507,GO:0005515,GO:0005737,GO:0005758,GO:0005758,GO:0006091,GO:0006825,GO:0008047,GO:0008284,GO:0016531,GO:0016531,GO:0016531,GO:0033617,GO:0033617,GO:0043167,GO:1903136,GO:1904960

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COX17 hsa:10063 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
COX17 hsa:10063 path:hsa01100 Metabolic pathways - Homo sapiens (human)
COX17 hsa:10063 path:hsa04714 Thermogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
COX17 MT-CO2 15229189 18458339 19393246 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR COX17 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 COX17 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 COX17 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 COX17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COX17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 COX17 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COX17 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 COX17 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000237AF9 COX17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 COX17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F COX17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 COX17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A79D1 COX17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D COX17 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004959F4 COX17 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SCO2 COX17 25361965 interaction type N/A PTMCode2
COX17 SCO2 25361965 interaction type N/A PTMCode2
SCO1 COX17 25361965 interaction type N/A PTMCode2
COX17 SCO1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 COX17 25348397 N/A physical interaction ComPPI
KRTAP10-8 COX17 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CFL1 COX17 25348397 N/A physical interaction ComPPI
KATNAL1 COX17 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
COX17 EEF1A1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COX17 UNC119 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COX17 ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COX17 LRIF1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
COX17 RBM48 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COX17 COPS6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COX17 PPBP 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COX17 EEF1A1P5 25348397 N/A physical interaction ComPPI
COX17 TP53 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COX17 COX14 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
COX17 COA1 25348397 N/A physical interaction ComPPI
COX17 HADHB 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
COX17 PCMT1 25348397 N/A physical interaction ComPPI
COX17 SOD1 25348397 N/A physical interaction ComPPI
COX17 SPR 25348397 N/A physical interaction ComPPI
COX17 TKT 25348397 N/A physical interaction ComPPI
COX17 UFC1 25348397 N/A physical interaction ComPPI
COX17 SCYL2 25348397 N/A physical interaction ComPPI
COX17 TALDO1 25348397 N/A physical interaction ComPPI
COX17 TBCA 25348397 N/A physical interaction ComPPI
COX17 SCO1 18458339 24234451 25348397 29568061 association mass spectrometry studies of complexes,nuclear magnetic resonance,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
COX17 SCO2 18458339 24234451 25348397 N/A nuclear magnetic resonance,physical interaction ComPPI,IntAct
COX17 CHCHD4 15359280 15989955 19182799 20026652 25348397 27898060 N/A nuclear magnetic resonance,pull down,physical interaction,oxidoreductase assay ComPPI,OmniPath
COX17 RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
COX17 SUMO2 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
COX17 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX17 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MIF COX17 25348397 N/A physical interaction ComPPI
PLGRKT COX17 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX17 COX17 11170391 14525934 N/A experimental interaction detection HPRD

Visualization