Gene Information gene info

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GENE：FADD

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FADD
FullNmae Fas associated via death domain
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3573
EnsembleID ENSG00000168040
Uniprot Q13158

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FADD necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FADD necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FADD mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FADD cuproptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FADD apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FADD apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FADD GO:0001822,GO:0001916,GO:0002020,GO:0002821,GO:0005123,GO:0005164,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0006915,GO:0008625,GO:0009898,GO:0031264,GO:0031264,GO:0031265,GO:0031265,GO:0032729,GO:0032757,GO:0032760,GO:0032813,GO:0033077,GO:0033612,GO:0035877,GO:0036462,GO:0042104,GO:0042802,GO:0043029,GO:0043065,GO:0043065,GO:0043123,GO:0044297,GO:0044877,GO:0045087,GO:0045089,GO:0045651,GO:0045862,GO:0045944,GO:0048148,GO:0048535,GO:0048536,GO:0048538,GO:0051607,GO:0060090,GO:0060340,GO:0060546,GO:0070236,GO:0071260,GO:0071550,GO:0089720,GO:0089720,GO:0089720,GO:0097049,GO:0097190,GO:0097191,GO:0097191,GO:0097191,GO:0097191,GO:0097192,GO:0097202,GO:0097342,GO:0097527,GO:2000454,GO:2001238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FADD hsa:8772 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
FADD hsa:8772 path:hsa04210 Apoptosis - Homo sapiens (human)
FADD hsa:8772 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
FADD hsa:8772 path:hsa04217 Necroptosis - Homo sapiens (human)
FADD hsa:8772 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
FADD hsa:8772 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
FADD hsa:8772 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
FADD hsa:8772 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
FADD hsa:8772 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
FADD hsa:8772 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
FADD hsa:8772 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
FADD hsa:8772 path:hsa05010 Alzheimer disease - Homo sapiens (human)
FADD hsa:8772 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
FADD hsa:8772 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
FADD hsa:8772 path:hsa05132 Salmonella infection - Homo sapiens (human)
FADD hsa:8772 path:hsa05142 Chagas disease - Homo sapiens (human)
FADD hsa:8772 path:hsa05152 Tuberculosis - Homo sapiens (human)
FADD hsa:8772 path:hsa05160 Hepatitis C - Homo sapiens (human)
FADD hsa:8772 path:hsa05161 Hepatitis B - Homo sapiens (human)
FADD hsa:8772 path:hsa05162 Measles - Homo sapiens (human)
FADD hsa:8772 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
FADD hsa:8772 path:hsa05164 Influenza A - Homo sapiens (human)
FADD hsa:8772 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
FADD hsa:8772 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
FADD hsa:8772 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
FADD hsa:8772 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
FADD hsa:8772 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
FADD hsa:8772 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FADD TRADD 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21183682 21232017 21411734 21826665 22955274 23010170 23170255 23180781 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
RIPK1 FADD 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11464215 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16227629 16406523 16498403 16585540 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21183682 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23180781 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26192618 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866 interaction type,physical association anti tag coimmunoprecipitation,two hybrid ACSN,InnateDB
TNF FADD 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
TRAF2 FADD 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866 interaction type N/A ACSN
FADD DAXX 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26192618 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866 interaction type N/A ACSN
FADD FAF1 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866 interaction type N/A ACSN
FADD FASLG 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866 interaction type N/A ACSN
FADD FAS 11003656 11274345 1134007 11464215 11583996 12215447 12702723 12721308 12724420 14744430 15592525 15760909 16406523 16410793 16498403 16762833 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23180781 23377657 23850759 24366341 24378531 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866 9880544 interaction type,physical association anti tag coimmunoprecipitation,two hybrid,gst pull down ACSN,InnateDB
FADD CFLAR 11003656 11274345 1134007 11583996 12215447 12220669 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17047155 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23180781 23377657 23850759 24366341 24378531 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
FADD MLKL 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
FADD RIPK3 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
FADD ATG5 11003656 11583996 15325588 15778222 16498403 17462996 20531300 22362782 23180781 23377657 23725295 23787782 24070470 26192618 26587781 26972597 27984721 28574505 9488730 interaction type,physical association anti tag coimmunoprecipitation,two hybrid,pull down ACSN,InnateDB
FADD CASP8 11003656 12220669 15325588 16410793 17047155 17462996 20531300 23180781 23725295 24070470 26192618 26587781 26972597 28574505 9488730 9774341 interaction type,physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer,gst pull down ACSN,InnateDB
FADD IKBKG 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
FADD MAP3K7 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
FADD TAB2 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
FADD TAB3 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26192618 26201938 26587781 26653790 26972597 28574505 8910423 9488730 interaction type N/A ACSN
GALNT14 FADD 10894161 17767167 19090789 20531300 26192618 28258062 interaction type N/A ACSN
PTPN13 FADD 12702723 12724420 16498403 23069999 26192618 9184224 interaction type N/A ACSN
FAIM FADD 12702723 16498403 17942717 23069999 26192618 9184224 interaction type N/A ACSN
SQSTM1 FADD 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26192618 26587781 28574505 9184224 interaction type N/A ACSN
TRIM13 FADD 26192618 26587781 interaction type N/A ACSN
CFLAR FADD 23180781 9208847 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10A FADD 10894161 15452120 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
FADD TNFSF10 10894161 16227629 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10B FADD 12721308 15452120 23180781 physical association anti tag coimmunoprecipitation,two hybrid,gst pull down InnateDB
MAVS FADD 16127453 18207245 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD DEDD 17193921 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD FADD 11717445 16410793 16762833 21525013 22890322 23180781 26467481 9774341 bind,physical association,up-regulates activity anti tag coimmunoprecipitation,fluorescent resonance energy transfer,gst pull down InnateDB,Signor
MYD88 FADD 17785432 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD IRAK1 17785432 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD RAP1A 15207703 23180781 physical association antibody array InnateDB
FADD CASP10 16585540 23180781 physical association two hybrid InnateDB
TRADD FADD 11464215 21183682 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TNFRSF1A FADD 15357952 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD PRKCZ 11739185 23180781 physical association anti tag coimmunoprecipitation InnateDB
FAS FADD 15993755 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD DAP3 15302871 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRIM21 FADD 21183682 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD EZR 21183682 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD TRIM21 21183682 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD TANK 21419663 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 FADD 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
FADD TNFRSF10A 20005715 interaction type N/A PSP
FADD TNFRSF10B 20005715 interaction type N/A PSP
FADD CFLAR 20005715 interaction type N/A PSP
FADD ABCA1 20005715 interaction type N/A PSP
FADD MAPK8 20005715 interaction type N/A PSP
FADD CSNK1A1 20005715 interaction type N/A PSP
FADD IRAK1 20005715 interaction type N/A PSP
FADD DAPK1 20005715 interaction type N/A PSP
FADD RHOA 20005715 interaction type N/A PSP
FADD RAP1A 20005715 interaction type N/A PSP
FADD PRKCZ 20005715 interaction type N/A PSP
FADD RIPK1 11854271 20005715 21071413 21737329 interaction type N/A PSP,SignaLink
FADD CASP8 20005715 interaction type N/A PSP
FADD RALBP1 20005715 interaction type N/A PSP
FADD MYD88 20005715 interaction type N/A PSP
FADD HIPK3 20005715 interaction type N/A PSP
FADD EDA2R 20005715 interaction type N/A PSP
FADD RIPK3 20005715 interaction type N/A PSP
FADD PRKCZ 11739185 18988627 20005715 N/A N/A SignaLink
FADD CSNK1A1 20005715 20005715 N/A N/A SignaLink
FADD IRAK1 11828002 18988627 20005715 20005715 N/A N/A SignaLink
FADD MAPK8 15659383 20005715 20005715 21071413 N/A N/A SignaLink
FADD RAP1A 20005715 20005715 N/A N/A SignaLink
FADD RHOA 15659383 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 FADD 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 FADD 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 FADD 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 FADD 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 FADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DEDD FADD 17193921 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 FADD 17956589 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001EFBE3 FADD 19965651 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00001EFBE3 FADD 19965651 22743998 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS0000338542 FADD 21706480 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000041CB9C FADD 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
AURKA FADD 22135298 phosphorylation N/A PhosphoSite
MAP2K7 FADD 22135298 phosphorylation N/A PhosphoSite
PLK1 FADD 22135298 phosphorylation N/A PhosphoSite
CSNK1A1 FADD 22135298 phosphorylation N/A PhosphoSite
CSNK2B FADD 22135298 phosphorylation N/A PhosphoSite
MAP3K1 FADD 22135298 phosphorylation N/A PhosphoSite
TNFSF10 FADD 25361965 interaction type N/A PTMCode2
FADD TNFSF10 25361965 interaction type N/A PTMCode2
ANK3 FADD 25361965 interaction type N/A PTMCode2
FADD ANK3 25361965 interaction type N/A PTMCode2
CASP10 FADD 25361965 interaction type N/A PTMCode2
FADD CASP10 25361965 interaction type N/A PTMCode2
NOL3 FADD 25361965 interaction type N/A PTMCode2
FADD NOL3 25361965 interaction type N/A PTMCode2
RIPK3 FADD 25361965 interaction type N/A PTMCode2
FADD RIPK3 25361965 interaction type N/A PTMCode2
MBD4 FADD 25361965 interaction type N/A PTMCode2
FADD MBD4 25361965 interaction type N/A PTMCode2
BCL10 FADD 25361965 interaction type N/A PTMCode2
FADD BCL10 25361965 interaction type N/A PTMCode2
XPO5 FADD 25361965 interaction type N/A PTMCode2
FADD XPO5 25361965 interaction type N/A PTMCode2
FADD HIPK3 25361965 interaction type N/A PTMCode2
HIPK3 FADD 25361965 interaction type N/A PTMCode2
FADD CFLAR 25361965 interaction type N/A PTMCode2
CFLAR FADD 25361965 interaction type N/A PTMCode2
FADD BID 25361965 interaction type N/A PTMCode2
BID FADD 25361965 interaction type N/A PTMCode2
FADD PIDD1 25361965 interaction type N/A PTMCode2
PIDD1 FADD 25361965 interaction type N/A PTMCode2
FADD EZR 25361965 interaction type N/A PTMCode2
EZR FADD 25361965 interaction type N/A PTMCode2
FADD TRADD 25361965 interaction type N/A PTMCode2
TRADD FADD 25361965 interaction type N/A PTMCode2
FADD DAP3 25361965 interaction type N/A PTMCode2
DAP3 FADD 25361965 interaction type N/A PTMCode2
FADD ATG5 25361965 interaction type N/A PTMCode2
ATG5 FADD 25361965 interaction type N/A PTMCode2
FADD DAPK1 25361965 interaction type N/A PTMCode2
DAPK1 FADD 25361965 interaction type N/A PTMCode2
FADD CASP8 25361965 interaction type N/A PTMCode2
CASP8 FADD 25361965 interaction type N/A PTMCode2
FADD MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 FADD 25361965 interaction type N/A PTMCode2
FADD PEA15 25361965 interaction type N/A PTMCode2
PEA15 FADD 25361965 interaction type N/A PTMCode2
FADD FASLG 25361965 interaction type N/A PTMCode2
FASLG FADD 25361965 interaction type N/A PTMCode2
FADD DEDD 25361965 interaction type N/A PTMCode2
DEDD FADD 25361965 interaction type N/A PTMCode2
FADD IKBKG 25361965 interaction type N/A PTMCode2
IKBKG FADD 25361965 interaction type N/A PTMCode2
FADD IRAK1 25361965 interaction type N/A PTMCode2
IRAK1 FADD 25361965 interaction type N/A PTMCode2
FADD PRKCZ 25361965 interaction type N/A PTMCode2
PRKCZ FADD 25361965 interaction type N/A PTMCode2
FADD SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 FADD 25361965 interaction type N/A PTMCode2
FADD FAF1 25361965 interaction type N/A PTMCode2
FAF1 FADD 25361965 interaction type N/A PTMCode2
FADD MYD88 25361965 interaction type N/A PTMCode2
MYD88 FADD 25361965 interaction type N/A PTMCode2
FADD RYBP 25361965 interaction type N/A PTMCode2
RYBP FADD 25361965 interaction type N/A PTMCode2
RIPK1 FADD 25361965 interaction type N/A PTMCode2
FADD RIPK1 25361965 interaction type N/A PTMCode2
TNFRSF10A FADD 25361965 interaction type N/A PTMCode2
FADD TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF1A FADD 25361965 interaction type N/A PTMCode2
FADD TNFRSF1A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 FADD 25348397 N/A physical interaction ComPPI
DAXX FADD 25348397 N/A physical interaction ComPPI
TRIM21 FADD 25348397 N/A physical interaction ComPPI
ZCCHC12 FADD 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RALBP1 FADD 14525934 16227629 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TNFAIP3 FADD 24234451 25348397 30561431 association physical interaction,virotrap ComPPI,IntAct
STAT1 FADD 10848577 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RYBP FADD 11395500 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DDIT4L FADD 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK8 FADD 25348397 N/A physical interaction ComPPI
KHDRBS1 FADD 25348397 N/A physical interaction ComPPI
NACA FADD 25348397 N/A physical interaction,in vitro,in vivo ComPPI
RHOA FADD 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
ARHGDIA FADD 25348397 N/A physical interaction ComPPI
CUL3 FADD 25348397 N/A physical interaction ComPPI
DAP3 FADD 11376335 11753396 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
FAF1 FADD 12702723 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NAXE FADD 25348397 N/A physical interaction ComPPI
PLK1 FADD 20890306 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,molecular sieving,pull down,protein kinase assay,confocal microscopy,immunodepleted coimmunoprecipitation ComPPI,IntAct
CASP8 FADD 11717445 12107169 12887920 14525934 14612908 17047155 17159907 17290218 18485876 19060883 19176810 19524512 20103630 21458669 21525013 21785459 21988832 22173242 22274400 23955153 24234451 25043603 25348397 25911380 30561431 8681376 9343261 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,two hybrid array,in vitro,in vivo,two hybrid,virotrap ComPPI,HPRD,IntAct
THAP12 FADD 25348397 N/A physical interaction ComPPI
TNFRSF1A FADD 16611992 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,IntAct
XPO5 FADD 12702765 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PEA15 FADD 10442631 10493725 14525934 22179576 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PRKCZ FADD 11739185 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRAK1 FADD 11828002 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FADD EDA2R 15280356 24234451 25348397 physical association coimmunoprecipitation,in vitro ComPPI,IntAct
FADD ABCA1 12235128 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
FADD CASP10 11717445 14525934 15069192 24234451 25348397 9045686 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
FADD MYD88 10880445 11828002 14525934 21988832 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
FADD RIPK1 11002422 14525934 19524513 21458669 21525013 24234451 25348397 30561431 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,virotrap ComPPI,HPRD,IntAct
FADD TRADD 10911999 11112409 14525934 23955153 24234451 25348397 30561431 8565075 8681376 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,two hybrid,virotrap ComPPI,HPRD,IntAct
FADD MBD4 12702765 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
FADD TNFRSF10B 14525934 24234451 25043603 25348397 9430227 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
FADD HIPK3 10640736 11034606 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FADD DEDD 14525934 25348397 9774341 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FADD CASP8AP2 10235259 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
FADD PIDD1 10825539 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FADD NOL3 14525934 15383280 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FADD RAP1A 14525934 15207703 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FADD TRAF2 14525934 16227629 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FADD TNFRSF10A 14525934 19427028 21785459 24234451 25348397 9430227 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
FADD DDX24 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FADD MOB4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FADD LRRCC1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FADD ANK3 14525934 14694156 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FADD PTPN13 14525934 16498403 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FADD FAS 11717445 14525934 16498403 17159907 18328427 19118384 21382479 21625644 21803845 24234451 25241761 25348397 7536190 7538907 9325248 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,transmission electron microscopy,cosedimentation in solution,experimental interaction detection,fluorescent resonance energy transfer,light scattering,mass spectrometry studies of complexes,molecular sieving,pull down,x-ray crystallography,physical interaction,electron tomography,imaging technique,in vitro,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
FADD FASLG 12887920 14525934 16498403 24025841 24234451 25241761 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
FADD BID 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
FADD EZR 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
FADD MSN 25348397 N/A physical interaction ComPPI
FADD NACA 12684039 24901053 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FADD NACA4P 25348397 N/A physical interaction ComPPI
FADD DAPK1 12911633 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct
FADD RALGDS 25348397 N/A physical interaction ComPPI
FADD IRF7 25348397 N/A physical interaction ComPPI
FADD MAVS 25348397 N/A physical interaction ComPPI
FADD TAB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FADD TNFSF10 10894160 12198154 16801533 19427028 20097879 21459798 21525171 21822306 22266862 23678861 24234451 25348397 association anti tag coimmunoprecipitation,coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
FADD CLIP3 25348397 N/A physical interaction ComPPI
FADD RIPK3 19524513 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FADD EDAR 25348397 N/A physical interaction ComPPI
FADD LRRK2 19176810 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FADD IKBKG 14525934 16227629 21458669 24234451 25348397 30561431 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,virotrap ComPPI,HPRD,IntAct
FADD PARK7 21785459 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
FADD MKRN9P 25348397 N/A physical interaction ComPPI
FADD MKRN1 25348397 N/A physical interaction ComPPI
FADD SPOP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FADD TNF 25348397 N/A physical interaction ComPPI
FADD ATG5 25348397 N/A physical interaction ComPPI
FADD ATG12 25348397 N/A physical interaction ComPPI
FADD NEFH 25348397 N/A physical interaction ComPPI
FADD IL37 25348397 N/A physical interaction ComPPI
FADD EHD1 25348397 N/A physical interaction ComPPI
FADD TLR3 25348397 N/A physical interaction ComPPI
FADD NLRC4 25348397 N/A physical interaction ComPPI
FADD TPPP 25348397 N/A physical interaction ComPPI
FADD SDCBP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FADD TCEA2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FADD SUMO1P1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FADD RNF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CFLAR FADD 14525934 17047155 24234451 25348397 9208847 association anti bait coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
BTG1 FADD 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FADD TAK1 25348397 N/A physical interaction ComPPI
CSNK1A1 FADD 14525934 16061179 24234451 30561431 association experimental interaction detection,virotrap HPRD,IntAct
FADD FADD 24234451 30561431 7536190 8681376 association,physical association two hybrid,two hybrid array,two hybrid prey pooling approach,virotrap IntAct
FADD ROBO2 24234451 30561431 association virotrap IntAct
FADD RHOQ 24234451 30561431 association virotrap IntAct
FADD NUP42 24234451 30561431 association virotrap IntAct
FADD DNAAF1 24234451 30561431 association virotrap IntAct
FADD TNIP1 24234451 30561431 association virotrap IntAct
FADD SLC7A11 24234451 30561431 association virotrap IntAct
FADD NDNF 24234451 30561431 association virotrap IntAct
FADD CCDC50 24234451 30561431 association virotrap IntAct
FADD CSNK1D 24234451 30561431 association virotrap IntAct
FADD KIF2C 24234451 30561431 association virotrap IntAct
FADD SDK2 24234451 30561431 association virotrap IntAct
FADD ROR1 24234451 30561431 association virotrap IntAct
FADD PREP 24234451 30561431 association virotrap IntAct
FADD PRDX4 24234451 30561431 association virotrap IntAct
FADD GOLGA7B 24234451 30561431 association virotrap IntAct
FADD EPB41L4B 24234451 30561431 association virotrap IntAct
FADD CKMT1A 24234451 30561431 association virotrap IntAct
FADD CHUK 24234451 30561431 association virotrap IntAct
FADD AKR7A2 24234451 30561431 association virotrap IntAct
FADD ULK3 24234451 30561431 association virotrap IntAct
FADD S1PR2 24234451 30561431 association virotrap IntAct
FADD RNF41 24234451 30561431 association virotrap IntAct
FADD IGHA1 24234451 30561431 association virotrap IntAct
FADD DLD 24234451 30561431 association virotrap IntAct
FADD ACTG1 24234451 30561431 association virotrap IntAct
TANK FADD 24234451 30561431 association virotrap IntAct
HSPD1 FADD 24234451 30021884 physical association cross-linking study IntAct
FADD MALT1 15746428 27898060 N/A N/A OmniPath
FADD TNFRSF25 27898060 9052839 9430227 N/A N/A OmniPath
CSNK1A1 FADD 10640736 11034606 16061179 19413330 19664995 20068231 20230923 27898060 inhibition N/A OmniPath
PLK1 FADD 20890306 27898060 inhibition N/A OmniPath
MAP3K1 FADD 15001534 27898060 inhibition N/A OmniPath
TNFRSF10B FADD 11376335 11940602 12721308 12920112 14585074 15173180 15388581 15452120 15659383 16980609 17585340 21272366 23142077 26186194 27898060 9430227 9430228 stimulant N/A OmniPath
FADD TNFRSF10B 11376335 11940602 12721308 12920112 15173180 15388581 15452120 15659383 16980609 17585340 21272366 23142077 26186194 27898060 9430227 9430228 N/A N/A OmniPath
PIDD1 FADD 10825539 16189514 16360037 27898060 N/A N/A OmniPath
MAVS FADD 16127453 18207245 27898060 N/A N/A OmniPath
FADD MYD88 10880445 11606776 11828002 17785432 21131052 21988832 27898060 inhibition N/A OmniPath
AURKA FADD 21978935 27898060 stimulant N/A OmniPath
TRADD FADD 10521396 10911999 11112409 11464214 11464215 12107169 12796506 12911633 14744432 16006552 16919273 18545270 21183682 21724995 21760970 23955153 24686082 27898060 8565075 8642271 8681376 9430228 stimulant N/A OmniPath
PRKCZ FADD 11739185 27898060 inhibition,stimulant N/A OmniPath
EZR FADD 15659383 21183682 25241761 27898060 N/A N/A OmniPath
FADD EZR 15659383 21183682 25241761 27898060 N/A N/A OmniPath
FADD CASP8 11717445 12107169 12220669 12702723 12887920 12911633 14612908 15280356 15659383 16410793 16469705 17047155 17159907 17290218 18485876 18708583 18946037 19060883 20448643 20829884 21458669 21525013 21620750 21737329 21737330 21785459 21988832 22179575 22274400 22421964 22864571 23142077 23972990 25043603 25911380 25939870 26437781 27898060 8681376 8681377 9228018 9343261 9774341 stimulant N/A OmniPath
CASP8 FADD 11717445 12107169 12220669 12702723 12887920 12911633 14612908 15280356 15659383 16410793 16469705 17047155 17159907 17290218 18485876 18708583 18946037 19060883 20448643 20829884 21458669 21525013 21620750 21737329 21737330 21785459 21988832 22179575 22274400 22421964 22864571 23142077 23972990 25043603 25911380 25939870 26437781 27898060 8681376 9228018 9343261 9774341 N/A N/A OmniPath
NOL3 FADD 15383280 27898060 inhibition N/A OmniPath
FADD CASP10 11717445 15069192 15659383 16585540 20829884 27898060 9045686 9228018 stimulant N/A OmniPath
CASP10 FADD 11717445 15069192 15659383 16585540 20829884 27898060 9045686 9228018 N/A N/A OmniPath
FAS FADD 10075697 10196099 10200300 10347191 10452970 10607716 10919673 10975811 11032752 11035039 11181697 11313933 11464214 11464215 11729181 11739735 11978827 12107169 12110583 12702723 12721308 12878044 14573612 15173180 15383280 15545353 15659383 15725726 15993755 16410793 16498403 16762833 17159907 18328427 19118384 20935634 21382479 21557211 21713032 21959933 22864571 25241761 26186194 27898060 7536190 7538907 8521815 8617770 8642271 8649383 8875942 8967952 9082980 9325248 9325306 9430227 9714541 9880544 9990010 stimulant N/A OmniPath
FADD FAS 10075697 10196099 10200300 10347191 10452970 10607716 10919673 10975811 11032752 11035039 11181697 11313933 11464214 11464215 11729181 11739735 11978827 12107169 12110583 12702723 12721308 12878044 14573612 15173180 15383280 15545353 15659383 15725726 15993755 16410793 16498403 16762833 17159907 18328427 19118384 20935634 21382479 21557211 21713032 21959933 22864571 25241761 26186194 27898060 7536190 7538907 8617770 8642271 8649383 8875942 8967952 9082980 9325248 9325306 9430227 9714541 9880544 9990010 N/A N/A OmniPath
MAPK1 FADD 15001534 27898060 N/A N/A OmniPath
TNFSF10 FADD 10894161 16227629 21822306 22266862 22585859 27898060 N/A N/A OmniPath
FADD RIPK1 11002422 11464215 11854271 16227629 16585540 18485876 18946037 19373245 19524513 21052097 21183682 21458669 21525013 21620750 21737329 22037414 22848449 22864571 22890322 22922561 23972990 24577083 26186194 26865630 27898060 stimulant N/A OmniPath
RIPK1 FADD 11002422 11464215 11854271 16227629 16585540 18485876 18946037 19373245 19524513 21052097 21183682 21458669 21620750 21737329 22037414 22848449 22864571 22922561 23972990 24577083 26186194 26865630 27898060 stimulant N/A OmniPath
FADD TNFRSF1A 10463949 11002422 11035039 15357952 15659383 16611992 21741934 27898060 8565075 8617770 8642271 9129204 N/A N/A OmniPath
CSNK2B FADD 26253696 27898060 N/A N/A OmniPath
CFLAR FADD 12220669 14637155 16469705 17047155 18708583 20829884 21737330 22322857 27898060 9208847 9217161 9228018 9326610 inhibition N/A OmniPath
FADD CFLAR 12220669 14637155 16469705 17047155 18708583 20829884 21737330 22322857 27898060 9208847 9228018 9326610 N/A N/A OmniPath
DAP3 FADD 11376335 11753396 15302871 27898060 N/A N/A OmniPath
FADD DAP3 11376335 11753396 15302871 27898060 N/A N/A OmniPath
FADD ATG5 15778222 18946037 22362782 27898060 stimulant N/A OmniPath
ATG5 FADD 15778222 18946037 22362782 27898060 N/A N/A OmniPath
MAP2K7 FADD 15001534 27898060 inhibition N/A OmniPath
FADD IRAK1 11828002 17785432 27898060 N/A N/A OmniPath
TNFRSF10A FADD 10894161 11376335 12920112 14585074 15280356 15388581 15452120 16980609 19427028 21272366 23142077 27898060 9430227 9430228 stimulant N/A OmniPath
FADD TNFRSF10A 10894161 11376335 12920112 15280356 15388581 15452120 16980609 19427028 21272366 23142077 27898060 9430227 9430228 N/A N/A OmniPath
TANK FADD 21419663 27898060 N/A N/A OmniPath
DUSP26 FADD 24548998 27898060 inhibition N/A OmniPath
RAP1A FADD 15207703 27898060 N/A N/A OmniPath
FADD TRIM21 21183682 27898060 N/A N/A OmniPath
FADD DEDD 11741985 17193921 27898060 9774341 stimulant N/A OmniPath
HIPK3 FADD 10640736 11034606 19413330 19664995 20068231 20230923 27898060 N/A N/A OmniPath

Visualization










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