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GENE：FAS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FAS
FullNmae Fas cell surface death receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11920
EnsembleID ENSG00000026103
Uniprot P25445

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FAS necroptosis 35013338 Here, we show that the pattern of cell death of muscle fibers in polymyositis is FAS ligand-dependent necroptosis, while that of satellite cells and myoblasts is perforin 1/granzyme B-dependent apoptosis, using human muscle biopsy specimens of polymyositis patients and models of polymyositis in vitro and in vivo. retulator signature
FAS immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FAS cuproptosis 36118866 A cuproptosis-related score model incorporating TRAF2, TRADD, USP21, FAS, MLKL, TNFRSF10B, MAPK8, TRAF5, and RIPK3 was developed. retulator signature
FAS autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FAS apoptosis 11793363 Since many different tumours express Fas on their membrane, targeting Fas-mediated apoptosis by anti-Fas antibodies may be a promising anticancer therapy. retulator signature
FAS apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FAS GO:0001934,GO:0005031,GO:0005515,GO:0005516,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006915,GO:0006924,GO:0006955,GO:0007165,GO:0009897,GO:0009986,GO:0016604,GO:0019900,GO:0031264,GO:0031265,GO:0031265,GO:0032872,GO:0032872,GO:0033209,GO:0034198,GO:0036337,GO:0038023,GO:0042802,GO:0042981,GO:0043065,GO:0043065,GO:0043066,GO:0045121,GO:0045121,GO:0065003,GO:0070062,GO:0071260,GO:0071455,GO:0097049,GO:0097191,GO:0097192,GO:0097527,GO:0097527,GO:2001235,GO:2001269,GO:2001269

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FAS hsa:355 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
FAS hsa:355 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
FAS hsa:355 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
FAS hsa:355 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
FAS hsa:355 path:hsa04210 Apoptosis - Homo sapiens (human)
FAS hsa:355 path:hsa04217 Necroptosis - Homo sapiens (human)
FAS hsa:355 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
FAS hsa:355 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
FAS hsa:355 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
FAS hsa:355 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
FAS hsa:355 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
FAS hsa:355 path:hsa05010 Alzheimer disease - Homo sapiens (human)
FAS hsa:355 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
FAS hsa:355 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
FAS hsa:355 path:hsa05142 Chagas disease - Homo sapiens (human)
FAS hsa:355 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
FAS hsa:355 path:hsa05160 Hepatitis C - Homo sapiens (human)
FAS hsa:355 path:hsa05161 Hepatitis B - Homo sapiens (human)
FAS hsa:355 path:hsa05162 Measles - Homo sapiens (human)
FAS hsa:355 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
FAS hsa:355 path:hsa05164 Influenza A - Homo sapiens (human)
FAS hsa:355 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
FAS hsa:355 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
FAS hsa:355 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
FAS hsa:355 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
FAS hsa:355 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
FAS hsa:355 path:hsa05200 Pathways in cancer - Homo sapiens (human)
FAS hsa:355 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
FAS hsa:355 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
FAS hsa:355 path:hsa05330 Allograft rejection - Homo sapiens (human)
FAS hsa:355 path:hsa05332 Graft-versus-host disease - Homo sapiens (human)
FAS hsa:355 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FASLG FAS 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22075988 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866 interaction type N/A ACSN
DAXX FAS 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26192618 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866 interaction type N/A ACSN
FADD FAS 11003656 11274345 1134007 11464215 11583996 12215447 12702723 12721308 12724420 14744430 15592525 15760909 16406523 16410793 16498403 16762833 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23180781 23377657 23850759 24366341 24378531 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866 9880544 interaction type,physical association anti tag coimmunoprecipitation,two hybrid,gst pull down ACSN,InnateDB
FAS FAF1 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866 interaction type N/A ACSN
RIPK1 FAS 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866 interaction type N/A ACSN
CFLAR FAS 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
TRAF2 FAS 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26192618 26587781 26653790 26972597 27984721 28574505 9488730 9759866 interaction type N/A ACSN
MLKL FAS 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
RIPK3 FAS 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26192618 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866 interaction type N/A ACSN
PTPN13 FAS 12702723 12724420 16498403 18195016 23069999 23180781 26192618 9184224 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
FAIM FAS 12702723 16498403 17942717 23069999 26192618 9184224 interaction type N/A ACSN
SQSTM1 FAS 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26192618 26587781 28574505 9184224 interaction type N/A ACSN
BTK FAS 23180781 9880544 physical association anti tag coimmunoprecipitation InnateDB
CASP8 FAS 12721308 17047155 17898872 22421964 23180781 9208847 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
FAS RAP1A 15207703 23180781 physical association antibody array InnateDB
BMX FAS 15207703 23180781 physical association anti tag coimmunoprecipitation InnateDB
BABAM2 FAS 15465831 23180781 physical association anti tag coimmunoprecipitation InnateDB
FAS FADD 15993755 23180781 physical association anti tag coimmunoprecipitation InnateDB
FAS CFLAR 15993755 23180781 physical association anti tag coimmunoprecipitation InnateDB
FAS CASP8 15993755 23180781 physical association anti tag coimmunoprecipitation InnateDB
FAS PRKCZ 15993755 23180781 physical association anti tag coimmunoprecipitation InnateDB
FAS PAWR 15993755 23180781 physical association anti tag coimmunoprecipitation InnateDB
HSF1 FAS 20396959 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
TP53 FAS 18443131 23180781 physical association anti tag coimmunoprecipitation InnateDB
LGALS1 FAS 18288482 23180781 physical association pull down InnateDB
LGALS3 FAS 15150087 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGR1 FAS 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
FAS FAS 14585074 19305384 21959933 26467481 bind,up-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
ETS1 FAS 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 FAS 10903433 19151767 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 FAS 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
TP53 FAS 10101800 11313989 12788915 16317104 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 FAS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FAS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FAS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FAS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FAS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FAS 10903433 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 FAS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 FAS 19670268 trascriptional regulation,stimulation inferred by curator TFlink
ATM FAS 19502594 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FAS 9300687 trascriptional regulation,stimulation inferred by curator TFlink
GLI1 FAS 21135115 trascriptional regulation,stimulation inferred by curator TFlink
GLI2 FAS 21135115 trascriptional regulation,stimulation inferred by curator TFlink
HDGF FAS 19710540 trascriptional regulation,stimulation inferred by curator TFlink
JUN FAS 10903433 19670268 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 FAS 10022897 10871852 16317104 16784892 19628709 7528667 9733827 trascriptional regulation,stimulation inferred by curator TFlink
NFKBIA FAS 9733827 trascriptional regulation,stimulation inferred by curator TFlink
NFYA FAS 9261184 trascriptional regulation,stimulation inferred by curator TFlink
NFYB FAS 9261184 trascriptional regulation,stimulation inferred by curator TFlink
NFYC FAS 9261184 trascriptional regulation,stimulation inferred by curator TFlink
PURA FAS 10903433 trascriptional regulation,stimulation inferred by curator TFlink
RELA FAS 10871852 16317104 16784892 19628709 9733827 trascriptional regulation,stimulation inferred by curator TFlink
SP1 FAS 10022897 10871852 22084312 9261184 9300785 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 FAS 10022897 10871852 22084312 9261184 9300785 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 FAS 12531699 18420801 20173757 9300785 trascriptional regulation,stimulation inferred by curator TFlink
SREBF2 FAS 9300785 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 FAS 16317104 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 FAS 15223310 16651438 22313388 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A FAS 7528667 trascriptional regulation,stimulation inferred by curator TFlink
YY1 FAS 16784892 17530016 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 FAS N/A trascriptional regulation,stimulation inferred by curator TFlink
EGR2 FAS N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB FAS N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000039E1E1 FAS 22431000 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00001EFBE3 FAS 20656888 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000009262D FAS 17991735 rna interference,inhibition array technology,quantitative reverse transcription pcr miRSponge
URS0000122ED0 FAS 19088304 21228813 22743998 25416803 mrna cleavage,inhibition array technology miRDeathDB,TarBase
URS000009262D FAS 20048743 25416803 mrna cleavage,inhibition array technology TarBase
URS00001EFBE3 FAS 20656888 23645835 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000039E1E1 FAS 22431000 25416803 27142596 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00005CC20C FAS 20542001 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS000052E1A6 FAS 22353710 25416803 25605245 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001CC864 FAS 23804233 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 FAS 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002E728C FAS 24955218 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00001DA458 FAS 24955218 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS000035CC3E FAS 24955218 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00000600E6 FAS 24955218 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00002075FA FAS 24955218 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS000032BD73 FAS 25416803 26919791 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00003CF1AD FAS 25416803 27277534 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000157F5 FAS 24297251 direct interaction,mrna cleavage,inhibition experimental interaction detection StarBase

Source Target Pmid Interactiontype Methods Database
UBE2I FAS 14525934 25348397 27898060 8940097 9257699 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
DAXX FAS 11003656 11495919 24234451 25241761 25348397 physical association anti bait coimmunoprecipitation,two hybrid,coimmunoprecipitation,pull down,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,IntAct
HNRNPC FAS 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
YES1 FAS 18328427 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOBTB3 FAS 25348397 N/A physical interaction ComPPI
UBA7 FAS 14525934 25348397 8940097 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
RARA FAS 25348397 N/A physical interaction ComPPI
CALM1 FAS 25348397 N/A pull down ComPPI
PTPN6 FAS 11786908 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP1LC3B FAS 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
BTK FAS 14525934 25348397 9751072 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK8 FAS 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
PIK3R1 FAS 25348397 N/A physical interaction ComPPI
PRKCA FAS 12586732 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
SRC FAS 18328427 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LCK FAS 14525934 25348397 8864141 N/A anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
INPP5D FAS 11786908 24234451 25348397 association pull down ComPPI,IntAct
PRAM1 FAS 25348397 N/A physical interaction ComPPI
RB1 FAS 25348397 N/A physical interaction ComPPI
SUMO1 FAS 11112409 14525934 24234451 25348397 8906799 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
RHOA FAS 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
ARHGDIA FAS 25348397 N/A physical interaction ComPPI
MAP1S FAS 25348397 N/A physical interaction ComPPI
FAF1 FAS 14525934 25348397 8524870 9740801 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BAG6 FAS 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CAV1 FAS 21382479 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
CASP8 FAS 11101867 11717445 12887920 14525934 16498403 17047155 17159907 18328427 21625644 21803845 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
MAP3K5 FAS 11495919 24234451 25241761 25348397 physical association anti bait coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
TRAF3 FAS 25348397 N/A physical interaction ComPPI
TNFRSF1A FAS 25348397 N/A physical interaction ComPPI
EEF1A1 FAS 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SQSTM1 FAS 25348397 N/A physical interaction ComPPI
FADD FAS 11717445 14525934 16498403 17159907 18328427 19118384 21382479 21625644 21803845 24234451 25241761 25348397 7536190 7538907 9325248 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,transmission electron microscopy,cosedimentation in solution,experimental interaction detection,fluorescent resonance energy transfer,light scattering,mass spectrometry studies of complexes,molecular sieving,pull down,x-ray crystallography,physical interaction,electron tomography,imaging technique,in vitro,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
TNF FAS 25348397 N/A physical interaction ComPPI
CD47 FAS 14525934 15917238 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
RUFY1 FAS 25348397 N/A physical interaction ComPPI
RAP1A FAS 14525934 15207703 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
KRIT1 FAS 14594800 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MET FAS 14525934 15911745 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EGFR FAS 12586732 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FASLG FAS 12887920 14525934 21803845 24234451 25241761 25348397 9126929 9228058 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
TCAP FAS 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTNNB1 FAS 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
TP63 FAS 25348397 N/A physical interaction ComPPI
CASP10 FAS 11717445 24234451 25348397 association coimmunoprecipitation,physical interaction ComPPI,IntAct
RIPK1 FAS 14525934 24234451 25348397 7538908 9740801 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
MSN FAS 25348397 N/A physical interaction ComPPI
CRMP1 FAS 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PTPN13 FAS 10918185 12724420 14525934 24234451 25348397 7536343 9079683 9835052 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
FYN FAS 14525934 17159908 24234451 25348397 8626376 colocalization cosedimentation through density gradient,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PDCD6 FAS 11606059 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
HIPK3 FAS 11034606 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
APAF1 FAS 14525934 25348397 9267021 N/A experimental interaction detection,in vivo ComPPI,HPRD
CFLAR FAS 21803845 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ANK3 FAS 14525934 14694156 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
LRIF1 FAS 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TRADD FAS 11032752 14525934 17692826 25348397 27898060 8681376 9427646 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
UBQLN1 FAS 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TUBB4A FAS 25348397 N/A physical interaction ComPPI
RIF1 FAS 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ECSIT FAS 25348397 N/A physical interaction ComPPI
CDYL FAS 25348397 N/A physical interaction ComPPI
PEX1 FAS 25348397 N/A physical interaction ComPPI
PML FAS 21803845 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFRSF10B FAS 25348397 N/A physical interaction ComPPI
CASP8AP2 FAS 10235259 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FEM1B FAS 10542291 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
FAS EZR 14525934 14676203 17159908 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FAS ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FAS FAIM2 10535980 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
FAS BID 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
FAS EEF1A1P5 25348397 N/A physical interaction ComPPI
FAS TNFSF13 10706119 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
FAS FBF1 10978533 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FAS BABAM2 25348397 N/A physical interaction ComPPI
FAS FAF2 25348397 N/A physical interaction ComPPI
FAS GADD45A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FAS APOA5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FAS CCND3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FAS ATP6V0B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FAS TMX1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FAS MBD4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FAS PRKAG1 25348397 N/A physical interaction ComPPI
FAS MC1R 25348397 N/A physical interaction ComPPI
FAS TUBB3 25348397 N/A physical interaction ComPPI
FAS TUBB2A 25348397 N/A physical interaction ComPPI
FAS TUBB2B 25348397 N/A physical interaction ComPPI
FAS COX16 25348397 N/A physical interaction ComPPI
FAS MDN1 25348397 N/A physical interaction ComPPI
FAS ALDH1L2 25348397 N/A physical interaction ComPPI
FAS EHD1 25348397 N/A physical interaction ComPPI
FAS NDUFAF1 25348397 N/A physical interaction ComPPI
FAS SPATA5 25348397 N/A physical interaction ComPPI
FAS GPD1L 25348397 N/A physical interaction ComPPI
FAS PDXDC1 25348397 N/A physical interaction ComPPI
FAS CHD1L 25348397 N/A physical interaction ComPPI
FAS SPATA5L1 25348397 N/A physical interaction ComPPI
FAS WDR11 25348397 N/A physical interaction ComPPI
FAS UGDH 25348397 N/A physical interaction ComPPI
FAS CTU2 25348397 N/A physical interaction ComPPI
FAS UFSP2 25348397 N/A physical interaction ComPPI
FAS INTS2 25348397 N/A physical interaction ComPPI
FAS ACAD9 25348397 N/A physical interaction ComPPI
FAS C17ORF75 25348397 N/A physical interaction ComPPI
FAS EEF1AKNMT 25348397 N/A physical interaction ComPPI
FAS ARF5 25348397 N/A physical interaction ComPPI
FAS FAM91A1 25348397 N/A physical interaction ComPPI
FAS DPH1 25348397 N/A physical interaction ComPPI
FAS MOCS3 25348397 N/A physical interaction ComPPI
FAS GET1 25348397 N/A physical interaction ComPPI
FAS TIMM29 25348397 N/A physical interaction ComPPI
FAS ALDH16A1 25348397 N/A physical interaction ComPPI
FAS SFXN5 25348397 N/A physical interaction ComPPI
FAS ABHD11 25348397 N/A physical interaction ComPPI
FAS GPN3 25348397 N/A physical interaction ComPPI
FAS PLCG1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
FAM118B FAS 25348397 N/A physical interaction ComPPI
FAS CALM2 14525934 14594800 24234451 association,physical association coimmunoprecipitation,experimental interaction detection,pull down HPRD,IntAct
FAS FAS 14525934 21382479 24234451 7536190 7538908 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,two hybrid HPRD,IntAct
DNAJC5 FAS 24234451 29997244 physical association bioluminescence resonance energy transfer IntAct
FAS PTPN13 10918185 12724420 18195016 27898060 7536343 9079683 9835052 N/A N/A OmniPath
PTPN13 FAS 10918185 12724420 18195016 27898060 7536343 9079683 9835052 inhibition N/A OmniPath
BABAM2 FAS 15465831 27898060 N/A N/A OmniPath
FAS CASP8AP2 10235259 27898060 stimulant N/A OmniPath
TTK FAS 15660394 17195092 27898060 N/A N/A OmniPath
FAS FADD 10075697 10196099 10200300 10347191 10452970 10607716 10919673 10975811 11032752 11035039 11181697 11313933 11464214 11464215 11729181 11739735 11978827 12107169 12110583 12702723 12721308 12878044 14573612 15173180 15383280 15545353 15659383 15725726 15993755 16410793 16498403 16762833 17159907 18328427 19118384 20935634 21382479 21557211 21713032 21959933 22864571 25241761 26186194 27898060 7536190 7538907 8521815 8617770 8642271 8649383 8875942 8967952 9082980 9325248 9325306 9430227 9714541 9880544 9990010 stimulant N/A OmniPath
FADD FAS 10075697 10196099 10200300 10347191 10452970 10607716 10919673 10975811 11032752 11035039 11181697 11313933 11464214 11464215 11729181 11739735 11978827 12107169 12110583 12702723 12721308 12878044 14573612 15173180 15383280 15545353 15659383 15725726 15993755 16410793 16498403 16762833 17159907 18328427 19118384 20935634 21382479 21557211 21713032 21959933 22864571 25241761 26186194 27898060 7536190 7538907 8617770 8642271 8649383 8875942 8967952 9082980 9325248 9325306 9430227 9714541 9880544 9990010 N/A N/A OmniPath
LGALS3 FAS 15150087 27898060 N/A N/A OmniPath
AKT1 FAS 15004527 27898060 inhibition N/A OmniPath
FAS MAP3K5 11495919 25241761 27898060 stimulant N/A OmniPath
STAT1 FAS 17992189 27898060 stimulant N/A OmniPath
BTK FAS 27898060 9751072 9880544 inhibition N/A OmniPath
TP53 FAS 27898060 9841917 stimulant N/A OmniPath
FAS CASP8 10196099 11101867 12721308 15659383 15993755 16498403 17047155 17159907 17898872 18328427 22421964 26186194 27898060 9208847 9325248 stimulant N/A OmniPath
CASP8 FAS 10196099 11101867 12721308 15659383 15993755 16498403 17047155 17159907 17898872 18328427 22421964 26186194 27898060 9208847 9325248 N/A N/A OmniPath
FAS DAXX 11003656 11193028 11483955 11495919 11773067 14637155 15725726 25241761 27898060 9215629 9743501 stimulant N/A OmniPath
DAXX FAS 11003656 11193028 11483955 11495919 11773067 14637155 15725726 25241761 27898060 9215629 9743501 inhibition N/A OmniPath
FASLG FAS 12753742 12887920 1375228 14965271 15659383 15725726 1713127 21803845 25241761 27898060 7505205 8521815 9039262 9126929 9228058 stimulant N/A OmniPath
NOL3 FAS 15383280 27898060 inhibition N/A OmniPath
FAS RIPK1 18545270 27898060 7538908 9740801 stimulant N/A OmniPath
RIPK1 FAS 18545270 27898060 7538908 9740801 stimulant N/A OmniPath
YY1 FAS 18495079 27898060 inhibition N/A OmniPath
TP73 FAS 19788416 27898060 stimulant N/A OmniPath
FAS CFLAR 15993755 27898060 9208847 9325248 N/A N/A OmniPath
LGALS1 FAS 18288482 27898060 N/A N/A OmniPath
RAP1A FAS 15207703 25241761 27898060 N/A N/A OmniPath
BMX FAS 15207703 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS0000759F33 FAS 15829500 28529080 direct interaction,inhibition experimental interaction detection lncRInter

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