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GENE：FDX1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FDX1
FullNmae ferredoxin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3638
EnsembleID ENSG00000137714
Uniprot P10109

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FDX1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FDX1 cuproptosis 36466876 Overall, 25 CuDEGs were identified, including ABCB6, BACE1, FDX1, GLS, LIAS, MT1M, PDHA1, etc. retulator signature
FDX1 cuproptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FDX1 cuproptosis 37864891 FDX1 is a ferrithionein responsible for transferring electrons from NADPH to mitochondrial cytochrome P450 via ferredoxin reductase. Driver
FDX1 cuproptosis 37864891 The knockout of seven genes, including FDX1 and the six genes encoding the lipoic acid pathway(LIPT1, LIAS, DLD) and lipid acylation protein targets, rescued the cytotoxic effect of these two compounds. Additionally, individual gene knockout studies confirmed that the deletion of FDX1 and LIAS rendered cells resistant to cupric-induced cell death, suggesting that FDX1 and protein lipid acylation are critical regulatory factors in cupric ion carrier-induced cell death. Driver
FDX1 cuproptosis 36882769 Knockout of seven of which could lead to the rescue of copper ionophores. These seven genes can be divided into three groups, FDX1, LA pathway-related genes (LIAS and LIPT1) and genes encoding components of pyruvate dehydrogenase complex (PDC) which play a crucial role in mitochondrial respiration (DLAT, DLD, PDHA1 and PDHB), all of which were correlated with LA pathway. regulator
FDX1 cuproptosis 37979442 Ferredoxin (FDX1), and lipoyl synthase (LIAS) were identified as key regulators of Cu toxicity. regulator
FDX1 cuproptosis 38299968 Bioinformatics analysis identified the differential expression of ferredoxin 1 (FDX1), a key positive regulator of cuproptosis in tumor cells. regulator
FDX1 cuproptosis 38168558 Among the CRGs in our study, 7 genes were pro-cuproptosis genes (FDX1, LIPT1, LIAS, DLD, PDHA1, DLAT and PDHB), 3 genes were anti-cuproptosis genes (MTF1, CDKN2A and GLS), and 2 genes were copper transporters (SLC31A1 and ATP7B). driver
FDX1 cuproptosis 38211899 It should be noted that DLD, PDHA and FDX1, as potential cuproptosis executors, were regulated by EIF4EBP1, ACHY, and ACTB in HMGA1 transcription regulons, respectively. driver
FDX1 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
FDX1 cuproptosis 38348451 FDX1 have emerged as pivotal orchestrators during copper ionophore-induced cell death CRGs in the cuproptosis pathway
FDX1 cuproptosis 35459854 The authors further confirmed that there was a high correlation among FDX1, LIAS, and DLAT (one of the four known target proteins for lipoylation) by analyzing the screening results of the metabolic gene sgRNA library. cuproptosis-related genes
FDX1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
FDX1 cuproptosis 36225932 Because the聽FDX1聽gene encodes a reductase that reduces Cu2+ to a more toxic Cu1+, given the pivotal role of the聽FDX1聽gene in cuproptosis, we hypothesized that the聽FDX1聽gene might help to evaluate the occurrence of this copper-induced cell death in ccRCC. driver
FDX1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
FDX1 cuproptosis 35298263 Our findings that knockout of either FDX1 or lipoylation-related enzymes rescues cells from copper toxicity led us to explore whether FDX1 might be an upstream regulator of protein lipoylation. driver
FDX1 cuproptosis 36341328 In addition, the knockout of nine genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, GCSH, and DBT) conferred resistance to cuproptosis driver
FDX1 cuproptosis 36118866 LA pathway cuproptosis gene
FDX1 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes
FDX1 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
FDX1 cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
FDX1 GO:0005506,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0006694,GO:0008203,GO:0009055,GO:0009055,GO:0022900,GO:0042446,GO:0051353,GO:0051537,GO:0071320,GO:0140647,GO:1904322

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FDX1 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 FDX1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 FDX1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FDX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 FDX1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000AD002 FDX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000045DBD FDX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BC91 FDX1 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000043D2C1 FDX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 FDX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 FDX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 FDX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A FDX1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004CD810 FDX1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FDX1 CYCS 25361965 interaction type N/A PTMCode2
CYCS FDX1 25361965 interaction type N/A PTMCode2
FDX1 CPNE1 25361965 interaction type N/A PTMCode2
CPNE1 FDX1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ATP5F1B FDX1 25348397 N/A physical interaction ComPPI
CYCS FDX1 14525934 25348397 27898060 6270113 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
HIF1A FDX1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NR4A2 FDX1 20195357 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CYP11A1 FDX1 1429635 14525934 1917982 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CLPP FDX1 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
PRKAB2 FDX1 25348397 N/A physical interaction ComPPI
GPATCH8 FDX1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CYP11B2 FDX1 14525934 25348397 27898060 3872685 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ATP5F1A FDX1 25348397 N/A physical interaction ComPPI
KSR1 FDX1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
FDXR FDX1 25348397 N/A in vitro ComPPI
FDX1 FDX2 25348397 N/A physical interaction ComPPI
FDX1 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSCB FDX1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
FDX1 FDX1 14525934 9890963 N/A experimental interaction detection HPRD

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