| LIAS |
immunogenic |
38538696 |
The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) |
retulator signature |
| LIAS |
cuproptosis |
36466876 |
Overall, 25 CuDEGs were identified, including ABCB6, BACE1, FDX1, GLS, LIAS, MT1M, PDHA1, etc. |
retulator signature |
| LIAS |
cuproptosis |
36341760 |
The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. |
regulator signature |
| LIAS |
cuproptosis |
37864891 |
LIAS is responsible for the conversion of lipoic acid to its oxidized form, oxidized thioctane amide. In biochemical reactions, one of the key functions of lipoic acid is to act as an acyl carrier during the decarboxylation of α-ketoacids. The sulfhydryl group at the sixth position of lipoic acid can bind the acyl group generated from the decarboxylation process, similar to coenzyme A. The final step involves transferring this acyl group to Coenzyme A. Therefore, LIAS plays a vital role in thioctyl acylation, leading to copper-induced cell death. |
Driver |
| LIAS |
cuproptosis |
37864891 |
The knockout of seven genes, including FDX1 and the six genes encoding the lipoic acid pathway(LIPT1, LIAS, DLD) and lipid acylation protein targets, rescued the cytotoxic effect of these two compounds. Additionally, individual gene knockout studies confirmed that the deletion of FDX1 and LIAS rendered cells resistant to cupric-induced cell death, suggesting that FDX1 and protein lipid acylation are critical regulatory factors in cupric ion carrier-induced cell death. |
Driver |
| LIAS |
cuproptosis |
36882769 |
Knockout of seven of which could lead to the rescue of copper ionophores. These seven genes can be divided into three groups, FDX1, LA pathway-related genes (LIAS and LIPT1) and genes encoding components of pyruvate dehydrogenase complex (PDC) which play a crucial role in mitochondrial respiration (DLAT, DLD, PDHA1 and PDHB), all of which were correlated with LA pathway. |
regulator |
| LIAS |
cuproptosis |
37979442 |
Ferredoxin (FDX1), and lipoyl synthase (LIAS) were identified as key regulators of Cu toxicity. |
regulator |
| LIAS |
cuproptosis |
38168558 |
Among the CRGs in our study, 7 genes were pro-cuproptosis genes (FDX1, LIPT1, LIAS, DLD, PDHA1, DLAT and PDHB), 3 genes were anti-cuproptosis genes (MTF1, CDKN2A and GLS), and 2 genes were copper transporters (SLC31A1 and ATP7B). |
driver |
| LIAS |
cuproptosis |
38495196 |
Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. |
63 cuproptosis-related genes |
| LIAS |
cuproptosis |
38348451 |
Involved in iron-sulfur cluster biogenesis. Copper and iron metabolism are interconnected, and disturbances in one can affect the other, potentially influencing cuproptosis. |
CRGs in the cuproptosis pathway |
| LIAS |
cuproptosis |
36313717 |
The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. |
Cuproptosis genes related mitochondrial respiration |
| LIAS |
cuproptosis |
36353226 |
Given that cuproptosis is triggered by lipoylated TCA cycle proteins, the protein lipoylation-related genes (GCSH,聽LIAS,聽LIPT1,聽LIPT2,聽NDUFAB1, and聽NNAT) among the different risk groups were analyzed. |
driver |
| LIAS |
cuproptosis |
36010978 |
Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. |
Cuproptosis-related genes |
| LIAS |
cuproptosis |
36341328 |
In addition, the knockout of nine genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, GCSH, and DBT) conferred resistance to cuproptosis |
driver |
| LIAS |
cuproptosis |
36118866 |
LA pathway |
cuproptosis gene |
| LIAS |
cuproptosis |
36685880 |
A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. |
cuproptosis-related genes |
| LIAS |
cuproptosis |
36568423 |
Additionally, 41 cuproptosis regulators were obtained from the previous publications. |
cuproptosis-related genes |
| LIAS |
cuproptosis |
36505872 |
A total of 44 cuproptosis-related genes were extracted from known literature. |
cuproptosis-related genes |
