GENE：DLAT
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DLAT |
| FullNmae | dihydrolipoamide S-acetyltransferase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2896 |
| EnsembleID | ENSG00000150768 |
| Uniprot | P10515 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DLAT | cuproptosis | 36276096 | This study aimed to evaluate the pan-cancer genomics and clinical association of cuproptosis and copper metabolism-related cell death genes, including SLC25A3, SLC25A37, SLC31A1, FDX1, DLAT, LIAS, ATP7A, ATP7B, COX17, SCO1, SCO2, COX11, and COX19. | retulator signature |
| DLAT | cuproptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| DLAT | cuproptosis | 37864891 | When there is an excessive accumulation of Cu2+ in mitochondria-dependent cells (Cu2+ enters the cell via copper ionophores), Cu2+ specifically binds to thioacylated DLAT, resulting in the heteropolymerization of DLAT. This causes an increase in insoluble DLAT, leading to cytotoxicity and cell death. | Driver |
| DLAT | cuproptosis | 36882769 | Knockout of seven of which could lead to the rescue of copper ionophores. These seven genes can be divided into three groups, FDX1, LA pathway-related genes (LIAS and LIPT1) and genes encoding components of pyruvate dehydrogenase complex (PDC) which play a crucial role in mitochondrial respiration (DLAT, DLD, PDHA1 and PDHB), all of which were correlated with LA pathway. | regulator |
| DLAT | cuproptosis | 37979442 | Cuproptosis is marked by the aggregation of lipoylated mitochondrial enzymes DLAT and a loss of iron-sulfur cluster (Fe-S) proteins. | Marker |
| DLAT | cuproptosis | 38181713 | The mitochondrial TCA cycle plays a crucial role in the occurrence of cuproptosis, where protein lipoylation is exclusive to four proteins (DBT, GCSH, DLST, and DLAT) involved in this cycle. | driver |
| DLAT | cuproptosis | 38168558 | Among the CRGs in our study, 7 genes were pro-cuproptosis genes (FDX1, LIPT1, LIAS, DLD, PDHA1, DLAT and PDHB), 3 genes were anti-cuproptosis genes (MTF1, CDKN2A and GLS), and 2 genes were copper transporters (SLC31A1 and ATP7B). | driver |
| DLAT | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| DLAT | cuproptosis | 38348451 | DLAT is another component of the pyruvate dehydrogenase complex. It interacts with lipoic acid and is involved in the conversion of pyruvate to acetyl-CoA. Like DBT, DLAT's function can be influenced by copper, and disruptions in copper homeostasis may impact its role in energy metabolism. | CRGs in the cuproptosis pathway |
| DLAT | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. | Cuproptosis genes related mitochondrial respiration |
| DLAT | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
| DLAT | cuproptosis | 36341328 | In addition, the knockout of nine genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, GCSH, and DBT) conferred resistance to cuproptosis | driver |
| DLAT | cuproptosis | 36118866 | PDH complex | cuproptosis gene |
| DLAT | cuproptosis | 36685880 | A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. | cuproptosis-related genes |
| DLAT | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
| DLAT | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
| DLAT | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DLAT | GO:0004742,GO:0004742,GO:0004742,GO:0005515,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0005967,GO:0005967,GO:0005967,GO:0005967,GO:0006006,GO:0006086,GO:0006086,GO:0006086,GO:0006099,GO:0034604,GO:0034604,GO:0042802,GO:0043231,GO:0045254 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DLAT | hsa:1737 | path:hsa00010 | Glycolysis / Gluconeogenesis - Homo sapiens (human) |
| DLAT | hsa:1737 | path:hsa00020 | Citrate cycle (TCA cycle) - Homo sapiens (human) |
| DLAT | hsa:1737 | path:hsa00620 | Pyruvate metabolism - Homo sapiens (human) |
| DLAT | hsa:1737 | path:hsa00785 | Lipoic acid metabolism - Homo sapiens (human) |
| DLAT | hsa:1737 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| DLAT | hsa:1737 | path:hsa01200 | Carbon metabolism - Homo sapiens (human) |
| DLAT | hsa:1737 | path:hsa01210 | 2-Oxocarboxylic acid metabolism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | DLAT | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | DLAT | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | DLAT | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | DLAT | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | DLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | DLAT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000324096 | DLAT | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00003D5391 | DLAT | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00004AC389 | DLAT | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DLAT | PDHA2 | 25361965 | interaction type | N/A | PTMCode2 |
| PDHA2 | DLAT | 25361965 | interaction type | N/A | PTMCode2 |
| DLAT | BCKDHB | 25361965 | interaction type | N/A | PTMCode2 |
| BCKDHB | DLAT | 25361965 | interaction type | N/A | PTMCode2 |
| DLAT | PDHA1 | 25361965 | interaction type | N/A | PTMCode2 |
| PDHA1 | DLAT | 25361965 | interaction type | N/A | PTMCode2 |
| DLD | DLAT | 25361965 | interaction type | N/A | PTMCode2 |
| DLAT | DLD | 25361965 | interaction type | N/A | PTMCode2 |
| PDHX | DLAT | 25361965 | interaction type | N/A | PTMCode2 |
| DLAT | PDHX | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| COX5B | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| ANXA1 | DLAT | 23754495 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| KEAP1 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| MAP1LC3B | DLAT | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| NF2 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| JUN | DLAT | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| COPS5 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| PSMA3 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| DLD | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| CANX | DLAT | 24234451 25348397 29568061 | association | pull down | ComPPI,IntAct |
| STAT5A | DLAT | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| STAT5B | DLAT | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PDHA2 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| PDHB | DLAT | 14638692 18206651 24234451 25348397 26186194 26344197 27898060 | N/A | molecular sieving,surface plasmon resonance,physical interaction | ComPPI,IntAct,OmniPath |
| PDHX | DLAT | 14525934 14638692 21988832 24234451 25348397 | physical association | two hybrid,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| PDHA1 | DLAT | 14525934 14638692 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| RAB5A | DLAT | 24234451 25348397 29568061 | association | pull down | ComPPI,IntAct |
| MDM2 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| ATP1B1 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| CUL1 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| ADRB2 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| SYNCRIP | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| HDAC6 | DLAT | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MAP1LC3A | DLAT | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| TSG101 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| PDK2 | DLAT | 12816949 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| DLAT | PDK1 | 11978179 14525934 24234451 25348397 29568061 | association | experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification | ComPPI,HPRD,IntAct |
| DLAT | PDK3 | 11978179 14525934 17683942 24234451 25348397 | N/A | experimental interaction detection,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| DLAT | PDK4 | 11978179 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| DLAT | SIRT7 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | OGDH | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | NDUFS4 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | MMGT1 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | HSPA1L | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | ACAD9 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | PCLAF | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | PRKD3 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| DLAT | PPT1 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | CS | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | CYC1 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | SDHB | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | DLST | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| DLAT | LMAN1 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | NDUFS2 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | CISD3 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | CDKN3 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | FOXD4 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | GABARAPL1 | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| DLAT | ESR2 | 24234451 25348397 25604459 | association | tandem affinity purification | ComPPI,IntAct |
| DLAT | SIRT4 | 24234451 25348397 25525879 | lipoprotein cleavage reaction,colocalization,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,confocal microscopy,lipoprotein cleavage assay | ComPPI,IntAct |
| DLAT | SIRT3 | 24234451 25348397 25525879 | deacetylation reaction | deacetylase assay | ComPPI,IntAct |
| DLAT | HSPD1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| DLAT | RAB9A | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| DLAT | SFXN1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| DLAT | TGOLN2 | 24234451 25348397 29568061 | association | pull down | ComPPI,IntAct |
| AURKAIP1 | DLAT | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MGST3 | DLAT | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| TRMT61B | DLAT | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MRPL1 | DLAT | 25348397 | N/A | physical interaction | ComPPI |
| DLAT | DLAT | 18184587 18184588 24234451 | N/A | electron tomography | IntAct |
| MKI67 | DLAT | 24234451 26949251 | association | anti tag coimmunoprecipitation | IntAct |