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GENE：PDHA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDHA1
FullNmae pyruvate dehydrogenase E1 subunit alpha 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8806
EnsembleID ENSG00000131828
Uniprot P08559

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDHA1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDHA1 cuproptosis 36466876 Overall, 25 CuDEGs were identified, including ABCB6, BACE1, FDX1, GLS, LIAS, MT1M, PDHA1, etc. retulator signature
PDHA1 cuproptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PDHA1 cuproptosis 36882769 Knockout of seven of which could lead to the rescue of copper ionophores. These seven genes can be divided into three groups, FDX1, LA pathway-related genes (LIAS and LIPT1) and genes encoding components of pyruvate dehydrogenase complex (PDC) which play a crucial role in mitochondrial respiration (DLAT, DLD, PDHA1 and PDHB), all of which were correlated with LA pathway. regulator
PDHA1 cuproptosis 38168558 Among the CRGs in our study, 7 genes were pro-cuproptosis genes (FDX1, LIPT1, LIAS, DLD, PDHA1, DLAT and PDHB), 3 genes were anti-cuproptosis genes (MTF1, CDKN2A and GLS), and 2 genes were copper transporters (SLC31A1 and ATP7B). driver
PDHA1 cuproptosis 38348451 Genes related to pyruvate metabolism. Changes in pyruvate metabolism can influence cellular energetics and contribute to cell death. CRGs in the cuproptosis pathway
PDHA1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
PDHA1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
PDHA1 cuproptosis 36118866 PDH complex cuproptosis gene
PDHA1 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes
PDHA1 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PDHA1 GO:0004739,GO:0004739,GO:0005515,GO:0005634,GO:0005730,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006086,GO:0006086,GO:0006099,GO:0034604,GO:0045254

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDHA1 hsa:5160 path:hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa00620 Pyruvate metabolism - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa00785 Lipoic acid metabolism - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa01200 Carbon metabolism - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
PDHA1 hsa:5160 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ADRB2 PDHA1 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PDHA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PDHA1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC PDHA1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PDHA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDHA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PDHA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PDHA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDHA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PDHA1 18971253 8476854 trascriptional regulation,stimulation inferred by curator TFlink
JUN PDHA1 8476854 trascriptional regulation,stimulation inferred by curator TFlink
SP1 PDHA1 8476854 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 PDHA1 8476854 trascriptional regulation,stimulation inferred by curator TFlink
AR PDHA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARA PDHA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARD PDHA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG PDHA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A PDHA1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000096022 PDHA1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000070B1D PDHA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002C0FCB PDHA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000A939F PDHA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002B2B5C PDHA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004CCA62 PDHA1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 PDHA1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF PDHA1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D PDHA1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C PDHA1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 PDHA1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003B6B84 PDHA1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C PDHA1 25416803 26309161 mrna cleavage,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PDK4 PDHA1 22135298 phosphorylation N/A PhosphoSite
SRC PDHA1 22135298 phosphorylation N/A PhosphoSite
PDPK1 PDHA1 22135298 phosphorylation N/A PhosphoSite
PDK2 PDHA1 22135298 phosphorylation N/A PhosphoSite
PDK3 PDHA1 22135298 phosphorylation N/A PhosphoSite
PDK1 PDHA1 22135298 phosphorylation N/A PhosphoSite
BCKDHB PDHA1 25361965 interaction type N/A PTMCode2
PDHA1 BCKDHB 25361965 interaction type N/A PTMCode2
DLAT PDHA1 25361965 interaction type N/A PTMCode2
PDHA1 DLAT 25361965 interaction type N/A PTMCode2
PDHX PDHA1 25361965 interaction type N/A PTMCode2
PDHA1 PDHX 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CHCHD3 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GOLGA2 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CHCHD2 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DES PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP5PO PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TFRC PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPN1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
LDHB PDHA1 25348397 N/A physical interaction ComPPI
LDHA PDHA1 25348397 N/A physical interaction ComPPI
TOMM22 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NUP62 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
AMOT PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EMD PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
LMNA PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DERL2 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPP1R2B PDHA1 25348397 N/A physical interaction ComPPI
CALM1 PDHA1 25348397 N/A physical interaction ComPPI
H2BC4 PDHA1 25348397 N/A physical interaction ComPPI
SMN1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FIP1L1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CPSF7 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MRPL23 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL10A PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RBM8A PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SND1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MAP4K1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF4G1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RHOA PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RBM4 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GTF2I PDHA1 25348397 N/A physical interaction ComPPI
CUL3 PDHA1 25348397 N/A physical interaction ComPPI
KPNB1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDIA3 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRPH PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ABCD3 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ACTN4 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RAB7A PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IRS4 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SERPINH1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UBC PDHA1 25348397 N/A physical interaction ComPPI
DLD PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 PDHA1 25348397 N/A physical interaction ComPPI
USO1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CKAP4 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COPA PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ITGB3BP PDHA1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HAX1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RRBP1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
P4HB PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPA1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
STAT5A PDHA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAT5B PDHA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NEFM PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PLEC PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
AKAP2 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL28 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HDLBP PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TMF1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HNRNPL PDHA1 25348397 N/A physical interaction ComPPI
PPP1R9B PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPR PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
VCL PDHA1 25348397 N/A physical interaction ComPPI
EIF6 PDHA1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
VDAC1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF2S1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDP1 PDHA1 14525934 24234451 25348397 7782287 dephosphorylation reaction experimental interaction detection,physical interaction,enzymatic study,in vitro ComPPI,HPRD,IntAct
PABPC1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
AGTRAP PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPM3 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHB PDHA1 12651851 14525934 19081061 24234451 25348397 29128334 7864652 association cross-linking study,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct
PDHX PDHA1 25348397 N/A physical interaction ComPPI
PDHA1 PDK1 11485553 11486000 12676647 14525934 24234451 25348397 29568061 7782287 phosphorylation reaction,association experimental interaction detection,physical interaction,enzymatic study,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
PDHA1 PDK2 11485553 11486000 12676647 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PDHA1 PDK3 11485553 11486000 12676647 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDHA1 PDK4 11485553 11486000 12676647 14525934 24234451 25348397 27505672 phosphorylation reaction experimental interaction detection,protein kinase assay,in vitro ComPPI,HPRD,IntAct
PDHA1 DLAT 14525934 14638692 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDHA1 DGKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHA1 USP19 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHA1 BABAM1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHA1 WDR20 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHA1 ATG101 25348397 N/A physical interaction ComPPI
PDHA1 SIRT7 25348397 N/A physical interaction ComPPI
PDHA1 OGDH 25348397 N/A physical interaction ComPPI
PDHA1 HNRNPDL 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ITGA4 25348397 N/A physical interaction ComPPI
PDHA1 ADRB2 25348397 N/A physical interaction ComPPI
PDHA1 ASL 25348397 N/A physical interaction ComPPI
PDHA1 GINS4 25348397 N/A physical interaction ComPPI
PDHA1 DCPS 25348397 N/A physical interaction ComPPI
PDHA1 MSN 25348397 N/A physical interaction ComPPI
PDHA1 NCDN 25348397 N/A physical interaction ComPPI
PDHA1 PPP1R2 25348397 N/A physical interaction ComPPI
PDHA1 HUWE1 25348397 N/A physical interaction ComPPI
PDHA1 PPT1 25348397 N/A physical interaction ComPPI
PDHA1 ABCE1 25348397 N/A physical interaction ComPPI
PDHA1 TEAD3 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHA1 ATP1B1 25348397 N/A physical interaction ComPPI
PDHA1 ANXA11 25348397 N/A physical interaction ComPPI
PDHA1 NDUFV1 25348397 N/A physical interaction ComPPI
PDHA1 PTBP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SDHB 25348397 N/A physical interaction ComPPI
PDHA1 TRIM2 25348397 N/A physical interaction ComPPI
PDHA1 TRIM3 25348397 N/A physical interaction ComPPI
PDHA1 CNTRL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDHA1 HDAC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHA1 HSD17B10 25348397 N/A physical interaction ComPPI
PDHA1 ACAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SIRT3 25348397 N/A physical interaction ComPPI
PDHA1 FOXD4 25348397 N/A physical interaction ComPPI
PDHA1 PARK7 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PYCR2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ANXA2P2 25348397 N/A physical interaction ComPPI
PDHA1 ANXA2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PYCR1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RPL32 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 H3-4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 STOML2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ACAA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SEC22B 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HSD17B4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MDH2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 FUBP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CHTOP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SCP2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RPL30 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 DBN1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SFXN1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RAB1C 25348397 N/A physical interaction ComPPI
PDHA1 RAB1B 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RPL12 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PHF5A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 H1-0 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 LRRC59 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ALYREF 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 AK2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ATAD3A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RAB5C 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HNRNPA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 NDUFS6 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 AIMP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HSDL2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ATP5PD 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ECI2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RAB1A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HNRNPH3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HNRNPA1L2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SHMT2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 IMMT 24234451 25348397 29128334 association,physical association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SCAMP3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 DHRS4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RPA3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ELAVL1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 H2BC11 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 POLDIP3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RAB11A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 UQCRC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MMGT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PABPN1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ATP1A1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TMED10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 THRAP3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 STX5 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CCT2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RPL35 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 H2BC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 DAZAP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HSPB1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RPN2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 DHX30 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 H1-10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TOMM40 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MRPL14 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CYB5R3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 UQCRC2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TMED4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MRPL2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TRAP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TP53 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SRRT 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 FUBP3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MRPL13 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 FMR1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ATAD3B 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 LSM12 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 GOLGB1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 INA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PNN 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PSPC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HNRNPAB 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CWC15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 G3BP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 LMNB1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CORO1C 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SURF6 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SLC25A3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 AIFM1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MACROH2A1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PRPF19 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ATP2A2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 IL4I1 25348397 N/A physical interaction ComPPI
PDHA1 DNAJA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PQBP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SERBP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CTTN 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TMPO 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TMPO 25348397 N/A physical interaction ComPPI
PDHA1 FLOT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MYO6 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 EEF1G 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RBM23 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 VDAC2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ZC3H14 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 DDOST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 EDC4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SFXN3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 NUP93 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 LDHAL6A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 EEF1E1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 GNL3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 DSG2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 WTAP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RPL13A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SRP68 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RARS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CTNNA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PRPF6 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ADAR 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ADD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HNRNPUL2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MYO1D 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 LIMA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 NCBP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ACIN1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CCT8 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 EIF3A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HP1BP3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RANGAP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MARS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MTCH2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SYMPK 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SUPT16H 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 NLN 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RBM27 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PHF6 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 LUC7L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CDK11B 25348397 N/A physical interaction ComPPI
PDHA1 CDK11A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CALD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 DNAJA2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PDCD6IP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SAFB 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 NUP107 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 RUVBL2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 GOLGA3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ATP2A1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PLRG1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 NOP58 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MYO1B 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 LBR 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 COLGALT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 FASN 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 IARS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 THOC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MTA2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SLC25A13 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TOP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CPT1A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ZC3HAV1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CWC22 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 DYNC1H1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 MYH11 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SMARCA5 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 SEC16A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 LRPPRC 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 HRNR 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 KIDINS220 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 CHD4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 NUMA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 DSP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 H2AC4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 ARPC4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 H2AC18 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 H3C15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TRIM25 25348397 N/A physical interaction ComPPI
PDHA1 TES 25348397 N/A physical interaction ComPPI
PDHA1 TARDBP 25348397 N/A physical interaction ComPPI
PDHA1 PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDHA1 VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
PDHA1 NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
PDHA1 COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
PDHA1 HSP90AB3P 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
H3C1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
H3-3A PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ILF2 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SEPTIN9 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
AGPS PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EEF1D PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SARNP PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IK PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRPF38A PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ACOT8 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 PDHA1 12651851 14525934 2377599 N/A experimental interaction detection HPRD
PDPK1 PDHA1 11092882 11485553 11486000 16436377 17065338 17474719 17957032 19081061 21680880 22195962 22289032 23138570 23685455 24148194 24858472 25053415 25104357 25237928 25243911 25257871 25404640 25995437 26378042 26483203 26497997 26506913 27898060 7782287 N/A N/A OmniPath
PDK1 PDHA1 11485553 11486000 12676647 15302935 16436377 18088087 18212344 18691976 18767875 19415658 20058876 20068231 20166139 27898060 7782287 inhibition N/A OmniPath
PDK2 PDHA1 11485553 11486000 12676647 16436377 17474719 18212344 18691976 18767875 19415658 20166139 27898060 inhibition N/A OmniPath
CSNK2A1 PDHA1 27898060 7273851 N/A N/A OmniPath
PDP1 PDHA1 14644048 16436377 16545080 20208177 27898060 7782287 stimulant N/A OmniPath
PDP2 PDHA1 14644048 16436377 20208177 27898060 stimulant N/A OmniPath
PDK4 PDHA1 11485553 11486000 12676647 15302935 16436377 17081983 17474719 17487921 18088087 18212344 18220336 18691976 18767875 19081061 19415658 19690332 20166139 27898060 7273851 inhibition N/A OmniPath
PDK3 PDHA1 11485553 11486000 12676647 15302935 16436377 18088087 18212344 18691976 18767875 19415658 20058876 20068231 20166139 27898060 N/A N/A OmniPath

Visualization










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