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GENE：PDHB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDHB
FullNmae pyruvate dehydrogenase E1 subunit beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8808
EnsembleID ENSG00000168291
Uniprot P11177

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDHB cuproptosis 36865349 Among three datasets, two cuproptosis-related genes (DLD and PDHB, p < 0.01 or 0.001) were stably upregulated in NAFLD. retulator signature
PDHB cuproptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PDHB cuproptosis 36882769 Knockout of seven of which could lead to the rescue of copper ionophores. These seven genes can be divided into three groups, FDX1, LA pathway-related genes (LIAS and LIPT1) and genes encoding components of pyruvate dehydrogenase complex (PDC) which play a crucial role in mitochondrial respiration (DLAT, DLD, PDHA1 and PDHB), all of which were correlated with LA pathway. regulator
PDHB cuproptosis 38168558 Among the CRGs in our study, 7 genes were pro-cuproptosis genes (FDX1, LIPT1, LIAS, DLD, PDHA1, DLAT and PDHB), 3 genes were anti-cuproptosis genes (MTF1, CDKN2A and GLS), and 2 genes were copper transporters (SLC31A1 and ATP7B). driver
PDHB cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
PDHB cuproptosis 38348451 Genes related to pyruvate metabolism. Changes in pyruvate metabolism can influence cellular energetics and contribute to cell death. CRGs in the cuproptosis pathway
PDHB cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
PDHB cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
PDHB cuproptosis 36341328 In addition, the knockout of nine genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, GCSH, and DBT) conferred resistance to cuproptosis driver
PDHB cuproptosis 36118866 PDH complex cuproptosis gene
PDHB cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes
PDHB cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PDHB GO:0004739,GO:0004739,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005739,GO:0005759,GO:0005967,GO:0005967,GO:0005967,GO:0006006,GO:0006086,GO:0006086,GO:0006086,GO:0006086,GO:0006099,GO:0034604,GO:0045254

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDHB hsa:5162 path:hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
PDHB hsa:5162 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
PDHB hsa:5162 path:hsa00620 Pyruvate metabolism - Homo sapiens (human)
PDHB hsa:5162 path:hsa00785 Lipoic acid metabolism - Homo sapiens (human)
PDHB hsa:5162 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PDHB hsa:5162 path:hsa01200 Carbon metabolism - Homo sapiens (human)
PDHB hsa:5162 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
PDHB hsa:5162 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
PDHB hsa:5162 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PDHB hsa:5162 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)
PDHB hsa:5162 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ADRB2 PDHB 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PDHB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PDHB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 PDHB 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000239117 PDHB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000040FA88 PDHB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A PDHB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001D6605 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PDHB 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDKN1A PDHB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNRPD1 PDHB 25348397 N/A physical interaction ComPPI
KEAP1 PDHB 25348397 N/A physical interaction ComPPI
MAP1LC3B PDHB 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
COX5A PDHB 25348397 N/A physical interaction ComPPI
EIF5 PDHB 25348397 N/A physical interaction ComPPI
GRB7 PDHB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
JUN PDHB 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
FHL2 PDHB 25348397 N/A physical interaction ComPPI
ITGB1 PDHB 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CUL3 PDHB 25348397 N/A physical interaction ComPPI
DLD PDHB 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 PDHB 25348397 N/A physical interaction ComPPI
STAT5A PDHB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAT5B PDHB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EEF1A1 PDHB 25348397 N/A physical interaction ComPPI
VDAC1 PDHB 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA2 PDHB 14525934 25348397 7864652 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PDHB PDHX 14525934 25348397 7864652 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PDHB PDHA1 12651851 14525934 19081061 24234451 25348397 29128334 7864652 association cross-linking study,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct
PDHB TRIM63 14525934 18468620 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PDHB DLAT 14638692 18206651 24234451 25348397 26186194 26344197 27898060 N/A molecular sieving,surface plasmon resonance,physical interaction ComPPI,IntAct,OmniPath
PDHB SRRM2 25348397 N/A physical interaction ComPPI
PDHB DYRK2 25348397 N/A physical interaction ComPPI
PDHB RAP1B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDHB RCC1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDHB ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDHB TSC22D1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDHB PFDN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDHB CAND1 25348397 N/A physical interaction ComPPI
PDHB FBXO6 25348397 N/A physical interaction ComPPI
PDHB RPSA 25348397 N/A physical interaction ComPPI
PDHB OGDH 25348397 N/A physical interaction ComPPI
PDHB ECT2 25348397 N/A physical interaction ComPPI
PDHB MDC1 25348397 N/A physical interaction ComPPI
PDHB FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PDHB ADRB2 25348397 N/A physical interaction ComPPI
PDHB FCER1A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PDHB GNB2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PDHB PCYT2 25348397 N/A physical interaction ComPPI
PDHB RRAGB 25348397 N/A physical interaction ComPPI
PDHB YWHAE 25348397 N/A physical interaction ComPPI
PDHB STAU1 25348397 N/A physical interaction ComPPI
PDHB HUWE1 25348397 N/A physical interaction ComPPI
PDHB RNF2 25348397 N/A physical interaction ComPPI
PDHB PPT1 25348397 N/A physical interaction ComPPI
PDHB PDK2 25348397 N/A physical interaction ComPPI
PDHB PDK1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PDHB PDK3 25348397 N/A physical interaction ComPPI
PDHB PPP3CB 25348397 N/A physical interaction ComPPI
PDHB PPP3CC 25348397 N/A physical interaction ComPPI
PDHB PPP3CA 25348397 N/A physical interaction ComPPI
PDHB ARMC8 25348397 N/A physical interaction ComPPI
PDHB RMND5A 25348397 N/A physical interaction ComPPI
PDHB GID4 25348397 N/A physical interaction ComPPI
PDHB BANP 25348397 N/A physical interaction ComPPI
PDHB PTP4A1 25348397 N/A physical interaction ComPPI
PDHB EEF1A1P5 25348397 N/A physical interaction ComPPI
PDHB PTBP1 25348397 N/A physical interaction ComPPI
PDHB TMCO1 25348397 N/A physical interaction ComPPI
PDHB UQCRQ 25348397 N/A physical interaction ComPPI
PDHB AKT1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PDHB HDAC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHB HSD17B10 25348397 N/A physical interaction ComPPI
PDHB ZNF746 25348397 N/A physical interaction ComPPI
PDHB DUSP29 25348397 N/A physical interaction ComPPI
PDHB FOXD4 25348397 N/A physical interaction ComPPI
PDHB CFAP20 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
PDHB COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHB DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHB DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHB PARK7 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHB SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHB BRF2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDHB WRAP73 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDHB MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDHB GH1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDHB IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDHB GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PDHB NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
PDHB SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
PDHB COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
PPP3R1 PDHB 25348397 N/A physical interaction ComPPI
PDHB PDHB 12651851 14525934 2377599 N/A experimental interaction detection HPRD
ADORA2A PDHB 24234451 28298427 physical association ubiquitin reconstruction IntAct

Source Target Pmid Interactiontype Methods Database
URS00009B8AD9 PDHB 27087310 direct interaction,inhibition N/A NPInter

Visualization










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