Gene Information gene info

  1. Home

GENE：GLS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GLS
FullNmae glutaminase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4331
EnsembleID ENSG00000115419
Uniprot O94925

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GLS cuproptosis 36466876 Overall, 25 CuDEGs were identified, including ABCB6, BACE1, FDX1, GLS, LIAS, MT1M, PDHA1, etc. retulator signature
GLS cuproptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GLS cuproptosis 36882769 Knock out lead to sensitive of cuproptosis. suppressor
GLS cuproptosis 38168558 Among the CRGs in our study, 7 genes were pro-cuproptosis genes (FDX1, LIPT1, LIAS, DLD, PDHA1, DLAT and PDHB), 3 genes were anti-cuproptosis genes (MTF1, CDKN2A and GLS), and 2 genes were copper transporters (SLC31A1 and ATP7B). suppressor
GLS cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
GLS cuproptosis 37983626 NFE2L2, NLRP3, GLS, LIPT1, and MTF1 were identified as potential cuproptosis predictors, thus shedding new light on ischemic stroke pathogenesis and heterogeneity. predictior
GLS cuproptosis 38348451 Plays a role in glutamine metabolism. Alterations in glutamine metabolism can impact cellular redox balance and contribute to oxidative stress, a hallmark of cuproptosis. CRGs in the cuproptosis pathway
GLS cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
GLS cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
GLS cuproptosis 36118866 PDH complex cuproptosis gene
GLS cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
GLS cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
GLS GO:0001967,GO:0002087,GO:0004359,GO:0004359,GO:0004359,GO:0005515,GO:0005739,GO:0005739,GO:0005759,GO:0005829,GO:0006537,GO:0006537,GO:0006537,GO:0006543,GO:0006543,GO:0006543,GO:0007268,GO:0045202,GO:0051289,GO:0090461

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GLS hsa:2744 path:hsa00220 Arginine biosynthesis - Homo sapiens (human)
GLS hsa:2744 path:hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
GLS hsa:2744 path:hsa00470 D-Amino acid metabolism - Homo sapiens (human)
GLS hsa:2744 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GLS hsa:2744 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
GLS hsa:2744 path:hsa04727 GABAergic synapse - Homo sapiens (human)
GLS hsa:2744 path:hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human)
GLS hsa:2744 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
GLS hsa:2744 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STAT1 GLS 22479354 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR GLS 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GLS 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 GLS 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GLS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 GLS 22479354 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 GLS 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00001CC864 GLS 25416803 27411920 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CUL5 GLS 25348397 N/A physical interaction ComPPI
SAP18 GLS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TAX1BP3 GLS 11163757 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
MAGEA6 GLS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FASTKD3 GLS 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
KEAP1 GLS 25348397 N/A physical interaction ComPPI
MCM2 GLS 25348397 N/A physical interaction ComPPI
UBB GLS 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
UBC GLS 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
RPS27A GLS 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
UBA52 GLS 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
PARD6A GLS 12629547 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
TNF GLS 25348397 N/A physical interaction ComPPI
ARF6 GLS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TUBA1A GLS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SNTA1 GLS 11163757 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
EIF5A GLS 25348397 N/A physical interaction ComPPI
CCL22 GLS 25348397 N/A physical interaction ComPPI
GDA GLS 25348397 N/A physical interaction ComPPI
FGB GLS 25348397 N/A physical interaction ComPPI
ATF6B GLS 25348397 N/A physical interaction ComPPI
NUFIP1 GLS 25348397 N/A physical interaction ComPPI
PDK1 GLS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MVD GLS 25348397 N/A physical interaction ComPPI
NDUFS7 GLS 25348397 N/A physical interaction ComPPI
OTC GLS 25348397 N/A physical interaction ComPPI
CAPN1 GLS 25348397 N/A physical interaction ComPPI
AURKAIP1 GLS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PEPD GLS 25348397 N/A physical interaction ComPPI
ATF2 GLS 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPATA20 GLS 25348397 N/A physical interaction ComPPI
MYL12B GLS 25348397 N/A physical interaction ComPPI
HSPD1 GLS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL4 GLS 25348397 N/A physical interaction ComPPI
AIFM1 GLS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATXN10 GLS 25348397 N/A physical interaction ComPPI
COX4I1 GLS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 GLS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HMGCL GLS 25348397 N/A physical interaction ComPPI
COQ9 GLS 25348397 N/A physical interaction ComPPI
GLS EIF5AL1 25348397 N/A physical interaction ComPPI
GLS GNS 25348397 N/A physical interaction ComPPI
GLS MYL12A 25348397 N/A physical interaction ComPPI
GLS MRPL43 25348397 N/A physical interaction ComPPI
GLS ETFBKMT 25348397 N/A physical interaction ComPPI
GLS PPA2 25348397 N/A physical interaction ComPPI
GLS ETFA 25348397 N/A physical interaction ComPPI
GLS MRM1 25348397 N/A physical interaction ComPPI
GLS RARS2 25348397 N/A physical interaction ComPPI
GLS OXLD1 25348397 N/A physical interaction ComPPI
GLS UNK 25348397 N/A physical interaction ComPPI
GLS SIRT5 25348397 N/A physical interaction ComPPI
GLS PTPMT1 25348397 N/A physical interaction ComPPI
GLS CISD3 25348397 N/A physical interaction ComPPI
GLS CFAP45 25348397 N/A physical interaction ComPPI
GLS YBEY 25348397 N/A physical interaction ComPPI
GLS ACAD9 25348397 N/A physical interaction ComPPI
GLS LAMP3 25348397 N/A physical interaction ComPPI
GLS ATCAY 25348397 N/A physical interaction ComPPI
GLS COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GLS SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GLS SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GLS SPRYD4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
GLS MICOS13 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
GLS COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
GLS COQ10A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SNRNP27 GLS 25348397 N/A physical interaction ComPPI
TRMT61B GLS 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HSCB GLS 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
GLS GLS 22049910 24234451 N/A x-ray crystallography IntAct
PRPF8 GLS 24234451 30021884 physical association cross-linking study IntAct
GLS MTUS1 24234451 30021884 physical association cross-linking study IntAct

Source Target Pmid Interactiontype Methods Database
URS00009B0B52 GLS 27087310 direct interaction,inhibition N/A NPInter

Visualization










  Return