GENE：GCSH
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GCSH |
| FullNmae | glycine cleavage system protein H |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4208 |
| EnsembleID | ENSG00000140905 |
| Uniprot | P23434 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GCSH | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GCSH | cuproptosis | 37279744 | Nine cuproptosis-related genes were differentially expressed between the severe CAP group and the control group: ATP7B, DBT, DLAT, DLD, FDX1, GCSH, LIAS, LIPT1, and SLC31A1. | retulator signature |
| GCSH | cuproptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| GCSH | cuproptosis | 38181713 | The mitochondrial TCA cycle plays a crucial role in the occurrence of cuproptosis, where protein lipoylation is exclusive to four proteins (DBT, GCSH, DLST, and DLAT) involved in this cycle. | driver |
| GCSH | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| GCSH | cuproptosis | 38348451 | GCSH is among the four known mammalian enzymes that can undergo protein lipoylation. Therefore, GCSH is an essential target involved in the copper death process. | CRGs in the cuproptosis pathway |
| GCSH | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. | Cuproptosis genes related mitochondrial respiration |
| GCSH | cuproptosis | 36353226 | Given that cuproptosis is triggered by lipoylated TCA cycle proteins, the protein lipoylation-related genes (GCSH,聽LIAS,聽LIPT1,聽LIPT2,聽NDUFAB1, and聽NNAT) among the different risk groups were analyzed. | driver |
| GCSH | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
| GCSH | cuproptosis | 36341328 | In addition, the knockout of nine genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, GCSH, and DBT) conferred resistance to cuproptosis | driver |
| GCSH | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
| GCSH | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GCSH | GO:0004047,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0005960,GO:0006546,GO:0009249,GO:0009249,GO:0019464 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GCSH | hsa:2653 | path:hsa00260 | Glycine, serine and threonine metabolism - Homo sapiens (human) |
| GCSH | hsa:2653 | path:hsa00630 | Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) |
| GCSH | hsa:2653 | path:hsa00785 | Lipoic acid metabolism - Homo sapiens (human) |
| GCSH | hsa:2653 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| GCSH | hsa:2653 | path:hsa01200 | Carbon metabolism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | GCSH | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | GCSH | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| E2F4 | GCSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GCSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | GCSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GCSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | GCSH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NMI | GCSH | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| GCSH | ZBTB16 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| GCSH | ING5 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| GCSH | PSMA1 | 25348397 | N/A | physical interaction | ComPPI |
| GCSH | PSMD5 | 25348397 | N/A | physical interaction | ComPPI |
| GCSH | PSMB5 | 25348397 | N/A | physical interaction | ComPPI |
| GCSH | MAGEA11 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| GCSH | CIDEB | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |